Drug Target Review

JULY 4, 2023

These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. ADCs have the potential to redress the poor balance between safety and efficacy seen with traditional cancer treatment options.

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Drug Discovery Today

AUGUST 16, 2021

Manchester, UK, August 11, 2021: Monument Therapeutics, a stratified medicine company, today announced Monument Therapeutics the appointment of Dr Julian Gilbert to its Board as a Non-Executive Director.

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The Pharma Data

NOVEMBER 23, 2021

Roche moment blazoned that new data from its expansive haematology portfolio will be presented at the American Society of Hematology (ASH) Annual Meeting and Exposition from 11-14 December 2021. 2 FL is the most common idle ( slow growing) form ofnon-Hodgkin carcinoma, a type of blood cancer, which frequently returns after original remedy.4

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Treatment Drugs Trials Disease 52

Common Sense for Drug Policy Blog

NOVEMBER 29, 2023

Receipt of Opioid Use Disorder Treatments Prior to Fatal Overdoses and Comparison to No Treatment "The findings revealed that exposures to MOUD, even if not continued throughout the six-month exposure period was associated with reduced risk of a fatal poisoning compared to non-MOUD forms of treatment and no treatment exposure.

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Treatment Drugs 52

Eye on FDA

JANUARY 9, 2022

In that respect, 2021 was not a banner year. Digital and social media are a primary resource for getting healthcare information and discussing treatment, especially now in the age of COVID. The Numbers: Looking first at the quantity of enforcement, the numbers were low. This year there were 5 regulatory action letters issued by OPDP.

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Drug Target Review

SEPTEMBER 21, 2023

The findings supported the possibility put forward by Cotton et al (2016) concerning the chance of repurposing these drugs for adulticidal treatment. The available treatment for that is minor surgery -to remove the nodules. With accessible and effective treatments, this is feasible. doi: 10.1002/14651858.CD011146.pub2.

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Drugs Treatment Disease Research 105

Drug Channels

NOVEMBER 19, 2021

Carolyn describes how oncology pathways were developed to help standardize treatment and ensure quality care. Read more » Copyright © 2006-2021 Pembroke Consulting, Inc. She argues, however, that these pathways often shut manufacturers out of the market. Read on for Carolyn’s insights. d/b/a Drug Channels Institute.

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Eye on FDA

AUGUST 4, 2021

Each committee is comprised of a number of experts, diverse for their expertise, geography and specialty – with some focused on statistics while others may be focused on areas of concentration within the category, such as the treatment of pediatric patients. Fewer meetings – more approvals. That gets us to the issue of vacancies.

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FDA Clinical Pharmacology FDA Approval Therapies 122

DrugBank

AUGUST 9, 2024

reported in 2021. However, searching for broader applicability and personalized approaches continues, as not all patients respond to these treatments. In 2021, an estimated 537 million adults were living with diabetes, a number projected to reach 643 million by 2030. billion in 2021, is projected to reach 231.7

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Pharmaceuticals Research Pharmaceutical Companies Clinical Trials 98

Drug Target Review

AUGUST 24, 2023

We will explore how GDF-15 impacts the tumour microenvironment and hinders the infiltration of T cells into the tumour, as well as the implications of neutralising GDF-15 to reverse its inhibitory effects and sensitise tumours to anti-PD-1 treatment. T-cell infiltration is a prerequisite for responses to checkpoint inhibitors.

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Treatment Therapies Clinical Development Cell Biology 98

Drug Target Review

DECEMBER 16, 2024

Despite challenges as a woman in the field, Dr Hingorani built a career focused on advancing treatments for pediatric and adult cancers. Despite the progress we are making in curing children with cancer, there remains an unmet need for new treatments that are more effective and safer.

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Medical Schools Clinical Research Drug Development Trials 52

FDA Law Blog: Biosimilars

DECEMBER 4, 2023

A prescription not issued in the usual course of professional treatment or in legitimate, authorized research is not a prescription within the meaning of the CSA and the pharmacist knowingly filling it, along with the prescriber issuing it, is subject to penalties. 21 U.S.C. § 829; 21 C.F.R. Complaint ¶ 55. Complaint ¶ 58. Complaint ¶ 59.

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Pharmacy Government Treatment Compliance 139

SugarCone Biotech

MARCH 24, 2025

Other mechanisms that cancer cells use to escape from TCE treatment are less expected. This provides ample flexibility to optimize the treatment modality to attack specific cancers. doi: 10.1136/jitc-2021-004348 6. CD58 is a protein that interacts with the CD2 protein that is expressed on T cells to upregulate T cell activation.

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Immune Response Therapies Treatment Disease 64

FDA Law Blog: Drug Discovery

DECEMBER 7, 2022

Valentine — On November 22, 2022, FDA approved CSL Behring’s BLA for Hemgenix (etranacogene dezaparvovec), an AAV-based gene therapy for the treatment of adults with Hemophilia B who currently use Factor IX prophylaxis therapy, have current or historical life-threatening hemorrhage, or have repeated, serious spontaneous bleeding episodes.

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National Institute on Drug Abuse: Nora's Blog

JULY 22, 2024

People with an opioid use disorder (OUD) urgently need treatment not just to protect them from overdosing but also to help them achieve recovery, but highly effective medications like buprenorphine and methadone remain underused. Almost all (99%) of those retained in treatment achieved remission. For instance, in 2021, the U.S.

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Drug Target Review

SEPTEMBER 25, 2024

4 Another related and well described non-oncogene resistance mechanism is the histological transformation of EGFR-mutated non-small cell lung cancer (NSCLC) to small-cell lung cancer upon treatment with an EGFR inhibitor. Notably, TT125-802 stabilised disease and prevented further outgrowth of tumours resistant to standard-of-care treatment.

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Small Molecule Therapies Regulations Treatment 105

SCIENMAG: Medicine & Health

AUGUST 14, 2023

According to data from Statistics Korea, cancer accounted for the majority of deaths in Korea in 2021, constituting 26% of all recorded cases. Among the various types of cancer, lung cancer stands out as the most prevalent, posing significant challenges in terms of treatment due […]

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International Treatment 77

Broad Institute

OCTOBER 11, 2023

Manguso, who’d recently graduated from college and was conducting research at the University of Copenhagen as a Fulbright scholar, moved back to the Boston area to be with his mother as she underwent treatment. His mother had a presentation of the disease that suggested her immune system was already on the job.

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The Pharma Data

APRIL 4, 2022

The high rate of unvaccinated people will continue to put a strain on hospitals and healthcare systems around the world, furthering the need for effective treatments for patients hospitalised with COVID-19,” said Levi Garraway, M.D., If approved, Actemra/RoActemra would be the first U.S. Roche also partnered with Gilead Sciences, Inc.,

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The Pharma Data

MAY 27, 2022

In the pivotal clinical study CARTITUDE-1, 98 percent of patients with relapsed or refractory multiple myeloma responded to a one-time treatment with ciltacabtagene autoleucel and 80 percent of patients who responded experienced a stringent complete response . to develop and commercialise cilta-cel.[1].

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Drug Target Review

OCTOBER 4, 2023

Antibody-drug conjugates (ADCs) have been a groundbreaking approach to cancer treatment with their ability to deliver cytotoxic drugs directly to diseased cells while sparing healthy tissues. Ultimately, flexibility in dual-payload ADC development means better treatments could reach patients sooner. Biomaterials 273 , 120817 (2021).

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Small Molecule Drugs Immune Response Targeted Protein Degradation 126

KIF1A

OCTOBER 14, 2023

The 2021 Natural History Study found that about 20% of KAND patients experience cerebral visual impairment , but the incidence is likely higher. Understanding how these symptoms cluster may inform clinicians as they perform additional testing or recruit additional experts in the treatment of patients with cerebral visual impairment.

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Chemical Biology and Drug Design

OCTOBER 2, 2023

Abstract Despite the successful reduction in the malaria health burden in recent years, it continues to remain a significant global health problem mainly because of the emerging resistance to first-line treatments.

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The Pharma Data

MARCH 28, 2022

Kerendia ™ (10 mg or 20 mg), a non-steroidal, selective mineralocorticoid receptor (MR) antagonist, is approved for the treatment of chronic kidney disease and type 2 diabetes, excluding patients with end-stage renal disease or on dialysis. Finerenone is different to existing CKD in T2D treatments. In Japan, an estimated 13.3

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Disease Treatment Clinical Trials Trials 52

The Pharma Data

MARCH 29, 2022

Opdivo -based treatments have shown clinical benefit in four Phase 3 trials in earlier stages of cancer. Food and Drug Administration approved Opdivo in combination with chemotherapy for the treatment of adult patients with resectable (tumors ? CT, in New Orleans, Louisiana. Based on the results of CheckMate -816, the U.S.

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Treatment Clinical Trials Trials Immune Response 52

The Pharma Data

NOVEMBER 18, 2021

Eli Lilly and Company blazoned that registration is now open for the CHALLENGE-MIG clinical trial, the first and only head-to- head trial comparing twoanti-calcitonin gene- related peptide (CGRP) drugs for the preventative treatment of episodic migraine in grown-ups.1 gepants) may help people achieve the pretensions that count most to them.

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Treatment Clinical Trials Trials Disease 52

The Pharma Data

AUGUST 27, 2020

The company has already tested the treatment on 10 adults between the ages of 56-70, and 10 over 71. There is hope that Moderna’s vaccine could be available by early 2021. . Each patient was given two 100 microgram doses of the vaccine 28 days apart. Conor Kavanagh. Source link.

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Vaccine Immune Response Clinical Trials Virus 90

Drug Patent Watch

DECEMBER 10, 2024

This growth is driven by the increasing demand for affordable biologic treatments and the loss of patent exclusivity for several blockbuster biologics. link] What Are Biosimilars, and How Do They Expand Treatment Options for Patients? link] An inflection point for biosimilars. link] Biosimilars advancements: Moving on to the future.

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Biosimilars Drugs Production Clinical Trials 97

The Pharma Data

NOVEMBER 19, 2021

government to supply 10 million treatment courses of its investigational COVID-19 oral antiviral seeker, PAXLOVID ™ (PF-07321332; ritonavir), subject to nonsupervisory authorization from theU.S. government will acquire 10 million treatment courses to be delivered by Pfizer beginning latterly this time and concluding in 2022.

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Drug Channels

NOVEMBER 5, 2021

To learn more about the risk-based care approach, download the free whitepaper: Risk-Based Care Helps Cancer Treatment Adherence. Read more » Copyright © 2006-2021 Pembroke Consulting, Inc. Read on for Ashleigh’s insights. d/b/a Drug Channels Institute. Drug Channels® is a registered trademark of Pembroke Consulting, Inc.

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Specialty Pharmacies Pharmacy Treatment Drugs 75

The Pharma Data

NOVEMBER 17, 2021

They also identified potential targeted treatments based on the findings, as reported in Science Advances in November. Patient similarity network of newly diagnosed multiple myeloma identifies patient subgroups with distinct genetic features and clinical implications, Science Advances, 2021. doi: 10.1126/sciadv.abg9551.

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Treatment RNA DNA Science 52

KIF1A

MARCH 16, 2024

Whole genome sequencing can identify additional mutations that aren’t included on CMT panels, providing patients with a more accurate diagnosis to find resources and treatments. billion people were affected by neurological disorders in 2021, making them a leading cause of disability worldwide.

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Disease Clinical Development Research Treatment 105

Broad Institute

MARCH 20, 2024

In 2021, we reported the discovery of a network of immune cells in colorectal cancer. By Broad and Mass General Communications March 20, 2024 Credit: Chen JH et al. Nature Immunology. doi: 10.1038/s41590-024-01792-2 (2024) Scientists used a microscope to visualize an immunity hub (yellow and green) in human lung tumor tissue (blue).

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Immune Response Hospitals Research Treatment 131

Drug Target Review

JULY 7, 2023

In pregnant individuals, maternal autoantibodies can even attack the organs and tissues of the foetus, 1-9 Many of these diseases are rare, with no safe, targeted, advanced and effective treatment options approved for patients in need. 16,17 There are currently no approved therapeutics for the treatment of HDFN.

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The Pharma Data

NOVEMBER 29, 2021

Deucravacitinib, an oral, selective tyrosine kinase 2 (TYK2) inhibitor, would be the first TYK2 inhibitor approved for the treatment of any disease. Bristol Myers Squibb moment blazoned that theU.S. The FDA has assigned a Tradition Medicine Stoner Figure Act (PDUFA) thing date of September 10, 2022.

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Treatment Clinical Trials Trials FDA 52

FDA Law Blog: Drug Discovery

SEPTEMBER 10, 2023

This finalized a draft guidance issued in December 2021, largely similar in substance. Even though the draft guidance was issued in 2021 after the onset of the COVID-19 pandemic, the Agency’s thinking now appears to be more reflective of this recent experience. Non-interventional studies thus do not require an IND.

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Eye on FDA

AUGUST 27, 2023

there has been a significant uptick – more in fact than any other previous mid-year check-in with the exception of 2021. There are still many decisions and publicly available PDUFA dates with many novel treatments among them, including investigative treatments for sickle cell disease and ALS.

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