2022 - Drug Discovery Digest

Small Molecule of the Year – 2022

Drug Hunter

APRIL 20, 2023

We asked the global drug discovery community to nominate and vote on their favorite molecule from 2022, and the results are in. The 2022 winner, with the most overall votes across the ten finalist molecules , is BMS’ oral, deuterated allosteric TYK2 inhibitor, deucravacitinib, the first new treatment for plaque psoriasis in nearly a decade.

Small Molecule

Small Molecule Clinical Trials Trials Licensing

The 2022 European drought: What was the role of climate change?

Science Daily: Pharmacology News

OCTOBER 21, 2024

The drought that lasted through the summer of 2022 was especially intense and caused the soil in many regions of Europe to dry out substantially. Public discussions about the causes repeatedly broached the question of the extent to which climate change intensified this extreme weather event.

Research

U.S. Measles Cases Reach 125, Surpassing Recent Peak in 2022

Drugs.com

APRIL 22, 2024

government data shows.That is more cases than were reported in all of 2022, the most recent annual peak. MONDAY, April 22, 2024 -- Measles infections continue to spread across the country, with 125 cases now reported in 18 states, new U.S.

Government

U.S. Maternal Deaths Declined in 2022

Drugs.com

MAY 2, 2024

THURSDAY, May 2, 2024 -- The number of American women who died at or soon after childbirth declined significantly in 2022, the latest government data shows, but the rate is still higher than pre-pandemic levels.The report from the U.S. National.

Government

U.S. Suicide Numbers Hit New Record High in 2022

Drugs.com

NOVEMBER 29, 2023

suicide numbers reached a grim new high in 2022. WEDNESDAY, Nov. 29, 2023 -- U.S. The increase was most acute among women over the age of 24, according to provisional data from the U.S. Centers for Disease Control and Prevention. Overall, almost.

Disease

Law enforcement seizures of psilocybin mushrooms rose dramatically between 2017-2022

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

Law enforcement seizures of “magic mushrooms” or “shrooms” containing the psychoactive component psilocybin increased dramatically in the United States between January 2017 and December 2022, according to a new study funded by the National Institute on Drug Abuse, part of the National Institutes of Health.

Drugs

Gross-to-Net Bubble Update: 2022 Pricing Realities at 10 Top Drugmakers (rerun)

Drug Channels

OCTOBER 4, 2023

When rebates and discounts were factored in, brand-name drug prices again declined—or grew slowly—in 2022. But for now, the 2022 data provide fresh inconvenient facts for the drug pricing flat earthers (#DPFE). You can find links to each company’s data below. However, some companies had net price gains. See the second chart below.

Pharmaceuticals

Pharmaceuticals Drugs

Fattening Doctors To Promote Weight Loss Drugs

Forbes: Drug Truths

JULY 20, 2023

In order to promote its weight-loss and diabetes drugs, Novo Nordisk bought doctors almost a half a million meals in 2022.

Doctors

Doctors Drugs

Interview with the Jones!Lab on development of novel genome editing tools

Drug Discovery Today

OCTOBER 27, 2022

27, Vilnius will host the EFIB’2022 event which will bring the European life science sector together. On October 26?27, In the field of life sciences, Lithuania is best known for the discovery of gene scissors by Prof. Virginijus Šikšnys.

Science

Science International Research

CAR-T for lupus: the ‘tip of the iceberg’ for cell therapy in autoimmune disease

BioPharma Drive: Drug Pricing

JANUARY 30, 2024

Since a landmark paper in 2022, drugmakers have begun nearly a dozen trials of cell therapies for lupus, with more set to start. Here’s why their efforts are worth watching.

Therapies

Therapies Disease Trials

Thirona’s RetCAD™ and iCare are joining forces in Europe to offer an integral solution for eye screening with artificial intelligence.

Drug Discovery Today

APRIL 29, 2022

Nijmegen, the Netherlands April 27th, 2022 – Thirona, one of the leading companies specializing in artificial intelligence for medical image analysis, has signed a strategic partnership agreement with iCare, for the implementation of Thirona’s RetCAD™ artificial intelligence software into the iCare solutions for eye disease screening, in Europe.

Disease

Buprenorphine now replaces methadone as the most common medicine for opioid dependence’: 10-year trends in opioid agonist treatment medicines in Australia

National Drug & Alcohol Research Centre Blog

DECEMBER 4, 2023

We converted information on monthly sales of methadone, sublingual buprenorphine (+/- naloxone) and buprenorphine between 2013 and 2022 into an estimate of the number of clients receiving these medicines each month, based on average doses in Australia (“client-months”). Chidwick, K., Farrell, M., & Degenhardt, L. Vol 123, p.

Treatment

Treatment Community Pharmacies Pharmacy International

More Women Underwent Surgical Sterilization After Fall of Roe v. Wade

Drugs.com

SEPTEMBER 11, 2024

Wade was overturned in 2022, rates of surgical sterilization rose in those states most affected by the decision, new research shows. WEDNESDAY, Sept. 11, 2024 -- As fears of the consequences of an unintended pregnancy rose after Roe v. Rates of.

Research

Global life expectancy to increase by nearly 5 years by 2050 despite geopolitical, metabolic, and environmental threats

Science Daily: Pharmacology News

MAY 17, 2024

years in females between 2022 and 2050. The latest findings forecast that global life expectancy will increase by 4.9 years in males and 4.2 Increases are expected to be largest in countries where life expectancy is lower, contributing to a convergence of increased life expectancy across geographies.

Disease

Humira leads ICER’s latest list of ‘unsupported’ price hikes

BioPharma Drive: Drug Pricing

DECEMBER 11, 2023

billion in 2022, according to the price watchdog’s latest yearly report. AbbVie’s blockbuster medicine topped a list of treatments that, combined, elevated U.S. healthcare spending by $1.3

Treatment

How Earth's most intense heat wave ever impacted life in Antarctica

Science Daily: Pharmacology News

SEPTEMBER 4, 2024

An atmospheric river brought warm, moist air to the coldest and driest corner of the planet in 2022, pushing temperatures 70 degrees above average. A new study reveals what happened to Antarctica's smallest animals.

Almost All Counterfeit Oxycontin Pills Contain Fentanyl

Drugs.com

MAY 7, 2024

TUESDAY, May 7, 2024 -- Lab tests of counterfeit oxycodone (Oxycontin) pills seized by police in Rhode Island in 2022 found 99.3% also contained dangerous fentanyl. It was typically mixed with another potentially deadly drug, xylazine.Both.

Drugs

Fall of Roe v. Wade Has Made Access to Ob/Gyns Tougher in Many States: Report

Drugs.com

JULY 18, 2024

Wade in June 2022, even more women have struggled to find reproductive care, a new report warns.Issued Thursday by the Commonwealth Fund, the report shows that women living. THURSDAY, July 18, 2024 -- Ever since the Supreme Court overturned Roe v.

SMR: THE INNOVATION LANDSCAPE

Drug Discovery Today

MARCH 1, 2024

In July 2022 the SMR hosted a conference on ‘Innovative new pharma and biotech partnerships: How is the landscape transforming?’

Pharmaceuticals

Stroke Rates Are Rising, Especially Among the Young

Drugs.com

MAY 23, 2024

THURSDAY, May 23, 2024 -- The rate at which Americans under the age of 65 suffered a stroke rose by about 15% between 2011 and 2022, new government data shows.That was true even among the young: The rate of stroke jumped 14.6% among people ages 18.

Government

U.S. Life Expectancy Rose Overall, But Overdose Deaths Still Set Records

Drugs.com

MARCH 21, 2024

THURSDAY, March 21, 2024 -- As the pandemic wound down, life expectancy in the United States began to bounce back in 2022, although deaths among children increased and drug overdose deaths continued to reach record highs, new government research.

Government

Government Research Drugs

U.S. Infant Deaths Rose After Fall of Roe v. Wade

Drugs.com

OCTOBER 21, 2024

Wade, a new study shows.The Dobbs ruling, handed down in July of 2022. MONDAY, Oct. 21, 2024 -- The United States experienced a small but significant rise in infant deaths in the months following the U.S. Supreme Court's decision overturned Roe v.

Databases from the Future: What is Database Version 954?

Perficient: Drug Development

OCTOBER 16, 2023

SQL Server 2022 (v16) will create future database if you simply run your database creation against a SQL 2022 instance. This will occur if your default instance is SQL 2022 regardless of how you go about generating your database. Emmett Brown. The first question: “Where did this come from?”

Big Rise in Emergencies Involving Synthetic Weed Among Kids, Adults

Drugs.com

MAY 8, 2024

poison centers regarding so-called synthetic cannabis jumped 88% between 2021 and 2022, as use of these legally sold products rose, research shows.Synthetic cannabis contain varying forms of the active. WEDNESDAY, May 8, 2024 -- Calls to U.S.

Production

Production Research

U.S. Syphilis Cases Continue to Climb

Drugs.com

JANUARY 30, 2024

The grim numbers are for 2022, the latest year for which an accurate tally is available. TUESDAY, Jan. 30, 2024 -- U.S. cases of syphilis have soared past numbers seen just a decade ago, new government statistics show. More than 202,000 cases were.

Government

High Rates of Loneliness Seen Among Bisexual and Transgender People

Drugs.com

JUNE 20, 2024

adults from 2022 finds the highest rates of. THURSDAY, June 20, 2024 -- Transgender and bisexual adults have rates of loneliness that are much higher than that of cisgender and heterosexual people, new data shows.Federal health data on U.S.

Number of Americans With Type 2 Diabetes Jumped by 20% in a Decade

Drugs.com

AUGUST 22, 2024

21, 2024 -- Type 2 diabetes increased by nearly 20% in the United States between 2012 and 2022, with age, race, income level, obesity and lack of exercise all playing a role in the metabolic disease’s spread, a new study r. THURSDAY, Aug.

The heat index -- how hot it really feels -- is rising faster than temperature

Science Daily: Pharmacology News

MARCH 20, 2024

Researchers showed in 2022 that heat index calculations by NOAA based on analyses from the 1970s don't adequately reflect the heat stress humans feel during the extremes of heat and humidity accompanying climate change.

Research

Sphere Fluidics begins work with partners on 3DSecret program to investigate mechanisms of metastasis in cancer

Drug Discovery Today

APRIL 27, 2023

3DSecret funded by European Innovation Council’s Pathfinder Open 2022, established under the EU Horizon Europe program. Consortium to leverage novel microfluidic technology to culture 3D cancer models for multi-parametric analysis, to inform cancer diagnostic and therapeutic development

Steady Rise in U.S. Cases of Tick-Borne Babesiosis Disease

Drugs.com

OCTOBER 9, 2024

9, 2024 -- Cases of a tick-borne parasitic disease have steadily increased in recent years, a new study shows.Rates of babesiosis increased an average 9% a year in the United States between 2015 and 2022, researchers reported in. WEDNESDAY, Oct.

Disease

Disease Research

Using Internal Traffic Control Plans to Prevent Construction Worker Injuries and Fatalities in Work Zones

NIOSH Science Blog: Drugs

APRIL 10, 2024

From 2011 to 2022, there were 1,462 fatal occupational injuries that occurred at road construction sites.[1] Struck-by injuries are the leading cause of nonfatal injuries and second most common cause of fatalities among construction workers.

International

America's Rural Hospitals Are Shutting Down Maternity Wards

Drugs.com

DECEMBER 5, 2024

2022, a majority (52%) of rural U.S. THURSDAY, Dec. 5, 2024 -- Hospitals across America are shuttering their obstetric units, and the issue is most acute for women served by rural hospitals, a new study finds.By hospitals no longer had any.

Hospitals

FDA Approved Oncology Drugs 2023

Crown Bioscience

JUNE 6, 2024

This marks the second-highest count in the past 30 years, with the highest being 59 new drug approvals in 2018 and represents an impressive 50% increase in drugs approved in 2022.

FDA Approval

FDA Approval FDA Drugs Research

Brightest gamma-ray burst of all time came from the collapse of a massive star

Science Daily: Pharmacology News

APRIL 12, 2024

In 2022, astronomers discovered the brightest gamma-ray burst (GRB) of all time. Now, astronomers confirm that a 'normal' supernova, the telltale sign of a stellar collapse, accompanied the GRB. The team also looked for signatures of heavy elements like gold and platinum in the supernova.

Pharma Plant Sleuthing: 8 Ways to Find Manufacturing Capacity as an Outsider

Drug Patent Watch

OCTOBER 2, 2024

However, you can employ several strategies to gather relevant data: Example: Pfizer’s 2022 Annual Report states, “Our manufacturing facilities are located in 39 countries across 6 continents. We operate 38 manufacturing… Source

Pharmaceuticals

In Mississippi, a Huge Jump in Cases of Babies Born With Syphilis

Drugs.com

SEPTEMBER 21, 2023

21, 2023 -- The United States is experiencing an alarming wave of congenital syphilis, and one southern state saw a 1,000% rise in babies born with the infection between 2016 and 2022. THURSDAY, Sept. The number of babies born with the infection in.

Video gaming improves mental well-being, landmark study finds

Science Daily: Pharmacology News

AUGUST 27, 2024

A pioneering study titled 'Causal effect of video gaming on mental well-being in Japan 2020-2022,' published in Nature Human Behaviour, has conducted the most comprehensive investigation to date on the causal relationship between video gaming and mental well-being.

Research

Tummy Tucks, Liposuctions Are Killing Americans Visiting Dominican Republic

Drugs.com

JANUARY 26, 2024

Between 2009 and 2022, 93 people -- almost all young or. FRIDAY, Jan. 26, 2024 -- Too many American tourists looking for cheap cosmetic surgeries alongside their beach time are winding up dead in the Dominican Republic, a new report finds.

Investigating newly discovered hydrothermal vents at depths of 3,000 meters off Svalbard

Science Daily: Pharmacology News

JUNE 28, 2024

During a 2022 expedition of the MARIA S. Hydrothermal vents can be found around the world at the junctions of drifting tectonic plates. But there are many hydrothermal fields still to be discovered. MERIAN, the first field of hydrothermal vents on the 500-kilometer-long Knipovich Ridge off the coast of Svalbard was discovered.

Diphtheria-Like Germ Can Be Passed Between People and Pets

Drugs.com

JUNE 13, 2024

The respiratory illnesses occurred in 2022 and 2023 and. THURSDAY, June 13, 2024 -- The first two cases of a diphtheria-like illness being transmitted in the United States between people and their pets have been reported in Utah and Colorado.

Lithuania to host one of the most important biotechnology events in Europe: EFIB’22

Drug Discovery Today

SEPTEMBER 9, 2022

On the 26th-27th of October, Vilnius is hosting the European Forum for Industrial Biotechnology & the Bioeconomy 2022 (EFIB'22). The forum will bring together business leaders, entrepreneurs, scientists, and investors as one of Europe's most meaningful events for biotechnology.

Science

Massive merger: Study reveals evidence for origin of supermassive black hole at galaxy's center

Science Daily: Pharmacology News

SEPTEMBER 6, 2024

The study builds on recent observations from the Event Horizon Telescope (EHT), which captured the first direct image of Sgr A* in 2022.

Research

Poll Finds Many Young Workers Feeling Stressed, Isolated

Drugs.com

JUNE 14, 2024

The 2022 Work in America survey, conducted by the American Psychological Association (APA), found that young adults are. FRIDAY, June 14, 2024 -- Many younger workers feel stressed, isolated and unappreciated at their jobs, a new survey has found.

ONDCP Launches New Recovery Ready Workplace Toolkit

NIOSH Science Blog: Drugs

JANUARY 10, 2024

In 2022, approximately 110,000 Americans died from a drug overdose. At the same time, 46 million Americans aged 18 or older experienced a substance use disorder in 2022. Nearly two thirds of those people (30.1 million) were employed. The drug overdose epidemic is occurring in and impacting workplaces.

Treatment

Treatment Drugs

Small Molecule of the Year – 2022

The 2022 European drought: What was the role of climate change?

Trending Sources

U.S. Measles Cases Reach 125, Surpassing Recent Peak in 2022

U.S. Maternal Deaths Declined in 2022

U.S. Suicide Numbers Hit New Record High in 2022

Law enforcement seizures of psilocybin mushrooms rose dramatically between 2017-2022

Gross-to-Net Bubble Update: 2022 Pricing Realities at 10 Top Drugmakers (rerun)

Fattening Doctors To Promote Weight Loss Drugs

Interview with the Jones!Lab on development of novel genome editing tools

CAR-T for lupus: the ‘tip of the iceberg’ for cell therapy in autoimmune disease

Thirona’s RetCAD™ and iCare are joining forces in Europe to offer an integral solution for eye screening with artificial intelligence.

Buprenorphine now replaces methadone as the most common medicine for opioid dependence’: 10-year trends in opioid agonist treatment medicines in Australia

More Women Underwent Surgical Sterilization After Fall of Roe v. Wade

Global life expectancy to increase by nearly 5 years by 2050 despite geopolitical, metabolic, and environmental threats

Humira leads ICER’s latest list of ‘unsupported’ price hikes

How Earth's most intense heat wave ever impacted life in Antarctica

Almost All Counterfeit Oxycontin Pills Contain Fentanyl

Fall of Roe v. Wade Has Made Access to Ob/Gyns Tougher in Many States: Report

SMR: THE INNOVATION LANDSCAPE

Stroke Rates Are Rising, Especially Among the Young

U.S. Life Expectancy Rose Overall, But Overdose Deaths Still Set Records

U.S. Infant Deaths Rose After Fall of Roe v. Wade

Databases from the Future: What is Database Version 954?

Big Rise in Emergencies Involving Synthetic Weed Among Kids, Adults

U.S. Syphilis Cases Continue to Climb

High Rates of Loneliness Seen Among Bisexual and Transgender People

Number of Americans With Type 2 Diabetes Jumped by 20% in a Decade

The heat index -- how hot it really feels -- is rising faster than temperature

Sphere Fluidics begins work with partners on 3DSecret program to investigate mechanisms of metastasis in cancer

Steady Rise in U.S. Cases of Tick-Borne Babesiosis Disease

Using Internal Traffic Control Plans to Prevent Construction Worker Injuries and Fatalities in Work Zones

America's Rural Hospitals Are Shutting Down Maternity Wards

FDA Approved Oncology Drugs 2023

Brightest gamma-ray burst of all time came from the collapse of a massive star

Pharma Plant Sleuthing: 8 Ways to Find Manufacturing Capacity as an Outsider

In Mississippi, a Huge Jump in Cases of Babies Born With Syphilis

Video gaming improves mental well-being, landmark study finds

Tummy Tucks, Liposuctions Are Killing Americans Visiting Dominican Republic

Investigating newly discovered hydrothermal vents at depths of 3,000 meters off Svalbard

Diphtheria-Like Germ Can Be Passed Between People and Pets

Lithuania to host one of the most important biotechnology events in Europe: EFIB’22

Massive merger: Study reveals evidence for origin of supermassive black hole at galaxy's center

Poll Finds Many Young Workers Feeling Stressed, Isolated

ONDCP Launches New Recovery Ready Workplace Toolkit

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