2022 and Biophysical Assays - Drug Discovery Digest

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2022

Biophysical Assays

Advancements in hit identification for membrane protein drug discovery

Drug Target Review

APRIL 7, 2025

The development of PoLiPa technology marks a new era in membrane protein drug discovery, rendering otherwise difficult targets accessible to structural biology, biophysical assays and other screening technologies. 2022) Why 90% of clinical drug development fails and how to improve it?, References Sun D, et al. 2022.02.002.

Fragment Screening

Fragment Screening Drugs Small Molecule Biophysical Assays

Obstacles and innovations of macrocyclic drug development

Drug Target Review

JANUARY 16, 2025

Cell , 185(19):35203532, 2022. Considering the impact drug-like properties have on the chance of success. Drug Discovery Today , 18(13-14):659666, 2013. Bhardwaj G, OConnor J, Rettie S, et al. Accurate de novo design of membrane-traversing macrocycles. Hoang HN, Hill TA, Fairlie DP. Angewandte Chemie , 133(15):84668471, 2021.

Drug Development

Drug Development Small Molecule Drugs FDA Approval

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Bridging Innovation & Patient Care: The Growing Role of AI

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Advancements in hit identification for membrane protein drug discovery

Obstacles and innovations of macrocyclic drug development

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