article thumbnail

Transforming high-throughput screening with mass spectrometry

Drug Discovery World

Trapped ion mobility spectrometry: Improving the specificity of MALDI-MS-based HTS . The ability of MALDI-enabled TOF and QTOF systems to discriminate between analytes and sample matrix background components based on their specificity is, like other MS techniques, dependent upon the mass resolution. References . Attene-Ramos and M.

article thumbnail

Flow cytometry technologies and cancer associated fibroblasts

Drug Discovery World

Flow cytometry is a high- throughput, cell-based assay used to examine properties of single cells. It has been used to investigate rare cell populations, screen potential drug therapeutics, and examine sample phenotypes for diagnostic applications 2. Volume 23 – Issue 4, Fall 2022. Physiological Reviews.

article thumbnail

Measure Cell Metabolism with Microplate Readers | BMG LABTECH

BMG Labtech

An active metabolism is a sign of viable cells and can be hence exploited by viability assays (fig.12) In addition, ATP is used as fuel by many luciferase-based assays. 005 (inactive 31 December 2022). Alberts B, How Cells Obtain Energy from Food, Molecular Biology of the Cell (4th ed.).