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New machine learning-based single-cell search engine makes cell annotation faster, more efficient

Broad Institute

We wanted to build a tool like that for cell biology. So we took lots of reference single-cell RNA sequencing data from atlases and used our scalable machine learning algorithms to embed all of the gene expression data on these cells into compact vector representations — you can think of these as a signature for each cell.

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#ScienceSaturday: March 2, 2024

KIF1A

Wendy Chung discusses advances from the Simons Foundation Powering Autism Research for Knowledge (SPARK) Project, which enrolled 275,000 participants with and without autism, between 2016 and 2022. This has created a platform to learn about autism-associated genes, identify risk factors for subgroups, and better inform new interventions.

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Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0” The underlying biology and processes upon which the company was founded have broad applicability across various human disease areas. Klein notes the importance of Dewpoint’s disease-agnostic approach.

Disease 98
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Optimising CRIPSR gene editing of hard-to-transfect cells

Drug Target Review

With its disruptive pipetting technology, SEED Biosciences is bridging the gap between the capabilities in liquid handling and the opportunities in single cell biology. In 2022, SEED Biosciences received its very first and prestigious New Product Award. He was awarded with the Ignite Award at SLAS 2019.

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A T cell receptor immunotherapy against a novel target

Drug Target Review

Can you explain the mechanism of action by which ImmTAC molecules selectively target and kill cancer cells? She has deep knowledge in Immunology and T cell biology, and 13 years of experience in Research (seven of them in biotech at Immunocore), including pipeline programme leadership.

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Optimising CRISPR gene editing of hard-to-transfect cells

Drug Target Review

With its disruptive pipetting technology, SEED Biosciences is bridging the gap between the capabilities in liquid handling and the opportunities in single cell biology. In 2022, SEED Biosciences received its very first and prestigious New Product Award. He was awarded with the Ignite Award at SLAS 2019.

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Scientists uncover a new approach for treating aggressive cancer

The Pharma Data

Their findings are published online in Nature Cell Biology. “We are amazed by the efficiency of small-molecule PROTAC in simultaneously targeting EZH2 and cMyc in cancer cells.” Nat Cell Biol, 2022. MS177 targets both EZH2 and cMyc and thus inhibit cancer growth. ” Wang J, Yu X, Gong W et al.