Drug Discovery World

AUGUST 17, 2023

DDW Volume 24 – Issue 3, Summer 2023 Biography: Alok Javali gained his PhD from the Institute of Stem Cell Biology and Regenerative Medicine. He joined Nicolas Rvron’s lab in 2020, where he co-invented human blastoids; the model of early human embryos derived solely from stem cells.

Cell Biology 130

Cell Biology International Science Drug Development 130

Drug Target Review

APRIL 12, 2024

With its disruptive pipetting technology, SEED Biosciences is bridging the gap between the capabilities in liquid handling and the opportunities in single cell biology. In 2022, SEED Biosciences received its very first and prestigious New Product Award. He was awarded with the Ignite Award at SLAS 2019.

Cell Biology 105

Cell Biology FDA Approval FDA Research 105

Drug Target Review

JUNE 5, 2023

As such, our team remains on track to complete our 5×5 strategy – laid out in October 2022 – by harnessing our technology and resources to continue efficiently growing Zymeworks’ pipeline of in-house and partnered candidates. Author Bio: Paul Moore, PhD Dr Moore joined Zymeworks in July 2022 as Chief Scientific Officer.

Treatment 100

Treatment Pharmacokinetics Cell Biology Drugs 100

Drug Target Review

APRIL 12, 2024

With its disruptive pipetting technology, SEED Biosciences is bridging the gap between the capabilities in liquid handling and the opportunities in single cell biology. In 2022, SEED Biosciences received its very first and prestigious New Product Award. He was awarded with the Ignite Award at SLAS 2019.

Cell Biology 98

Cell Biology FDA Approval FDA Research 98

PerkinElmer

JANUARY 21, 2022

Accelerating Capabilities for Dementia Biomarker Discovery To achieve that goal, the Dementia Platform’s focus involves studying the disease from many points of view – from lifestyle, age, and cognitive function, to genetics, cell biology, and phenotypic screening. 2022 [cited 6 January 2022]. Mrc.ukri.org.

Cell Biology 52

Cell Biology Disease Treatment Science 52

Drug Discovery World

OCTOBER 18, 2023

in Cell Biology and Biochemistry from University College London and was a post-doctoral fellow at Albert Einstein College of Medicine in New York City. Food & Drug Administration (2022) FDA Approves First Gene Therapy to Treat Adults with Hemophilia B. She received a Ph.D. References 1: U.S. Accessed 26 Jul 23.

Therapies 162

Therapies Clinical Trials FDA Approval Virus 162

The Pharma Data

MARCH 25, 2022

. “With the help of advanced laboratory techniques, we were able to identify a panel of nanobodies that very effectively neutralized several variants of SARS-CoV-2,” says Gerald McInerney, professor at the Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, and joint senior author of both studies.

Molecular Biology 52

Molecular Biology Laboratories Cell Biology Science 52

The Pharma Data

FEBRUARY 24, 2022

Their findings are published online in Nature Cell Biology. “We are amazed by the efficiency of small-molecule PROTAC in simultaneously targeting EZH2 and cMyc in cancer cells.” Nat Cell Biol, 2022. MS177 targets both EZH2 and cMyc and thus inhibit cancer growth. ” Wang J, Yu X, Gong W et al.

Small Molecule 52

Small Molecule Cell Biology Research Drug Development 52

Drug Discovery World

APRIL 16, 2023

The 2023 winner, Carolyn R Bertozzi, is the Baker Family Director of Sarafan ChEM-H, the Anne T and Robert M Bass Professor in the School of Humanities and Sciences, Professor of Chemistry and, by courtesy, of Chemical and Systems Biology and of Radiology at Stanford University.

Clinical Trials 130

Clinical Trials Vaccine Trials Science 130

Drug Discovery World

AUGUST 5, 2022

Volume 23 – Issue 3, Summer 2022. She holds a PhD in Molecular and Cell Biology from the Faculty of Medicine, University of Auvergne and a MSci in Biochemistry from the Faculty of Sciences, University of Lisbon. About the authors.

DNA 130

DNA Engineering Cell Biology Doctors 130

The Pharma Data

MARCH 15, 2022

. “The problem is that cells only make small amounts of p53 and then quickly break it down as it is a very large and disordered protein,” says the study’s last author Michael Landreh, researcher at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet. 2022.02.013. Source link: [link].

Cell Biology 52

Cell Biology DNA Research Vaccine 52

Drug Discovery World

OCTOBER 14, 2022

Lundblad, Drug Design, in Encyclopedia of Cell Biology (Volume 1), Elsevier, 2016. 15 Bruker launches new timsTOF-based MALDI PharmaPulse® solution for label-free HTS in drug discovery [News release], Bruker Daltonics, 2022. 17 Trapped Ion Mobility Spectrometry (TIMS), Bruker Daltonics, [link] [accessed 8 April 2022].

Synthetic Chemistry 130

Synthetic Chemistry Cell Based Assays Biochemical Assays Analytical Chemistry 130

Drug Discovery World

APRIL 14, 2023

He is being recognised for his fundamental discoveries dedicated to characterising the genetic drivers of human B-cell lymphomas and for uncovering new avenues for cancer prevention and therapy that have been routinely exploited clinically to diagnose and determine novel therapeutic strategies for B-cell lymphoma.

Clinical Trials 130

Clinical Trials Research Science Clinical Research 130

Drug Target Review

AUGUST 24, 2023

Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology. LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade. 2022 Jul 1;132(13). Biophysical Journal. 2021 Jul 6;120(13):2644-56.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

Drug Target Review

MAY 21, 2024

I don’t think that it’s harder for women to enter careers in STEM, at least not in the scientific field—cell biology—that I have predominantly worked in. The acquisition of Cellesce by Molecular Devices in 2022 celebrated Vicky’s leadership.

Doctors 58

Doctors Science Research Cell Biology 58

Drug Target Review

SEPTEMBER 19, 2023

Recent Nature publication (2022) demonstrates the speed and accuracy at which patient derived organoids contributed to a large scale functional screen of bispecific antibodies on a heterogenous colorectal cancer that reached clinical trials within 5 years from the initial development. From 3D cell culture to organs-on-chips.

Animal Testing 98

Animal Testing Clinical Trials Pharmaceutical Companies FDA 98

Drug Discovery World

OCTOBER 20, 2022

A limitation of conventional flow cytometry in the era of single cell biology is how many distinct pieces of information can be collected about each cell. Volume 23 – Issue 4, Fall 2022. Diversity and Biology of Cancer-Associated Fibroblasts. References: Biffi G, Tuveson DA. Physiological Reviews. 00048.2019.

Cell Based Assays 130

Cell Based Assays Therapies Cell Biology RNA 130

Broad Institute

JULY 28, 2023

He then moved to Boston where he received his postdoctoral training under the mentorship of Kerry Ressler at McLean Hospital, before he started his own lab in 2022. He is the recipient of several honors and fellowships, including a research scholarship from the German Research Foundation and NARSAD Young Investigator Awards in 2016 and 2022.

Medical Schools 52

Medical Schools Hospitals Regulations Research 52

The Pharma Data

MARCH 11, 2021

At Crop Science we’re targeting above-market growth from 2022. Second, the biorevolution is driving innovation in all of Bayer’s divisions – with major progress in cell biology, gene editing and data science. rate of 3 to 5 percent annually from 2022 through 2024, and thus faster than the market. “We

Science 52

Science Pharmaceuticals Licensing Licensing 52

The Pharma Data

OCTOBER 22, 2020

The launch of INTERLINK-1 represents an important financial milestone for Innate, as it triggers a $50 million milestone payment that fortifies our cash position through the end of 2022, ” said Mondher Mahjoubi, Chief Executive Officer of Innate Pharma. “

Clinical Trials 40

Clinical Trials Trials Cell Biology Production 40

Codon

APRIL 16, 2023

Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Read In Q1 2023, there was an 87% increase in biopharma layoffs, with 56 companies cutting staff compared to 30 in the same period of 2022. Nature Biotechnology. coli DNA using a Retro-Cascorder.

Engineering 52

Engineering DNA RNA Science 52

Codon

APRIL 2, 2023

An open-source FACS automation system for high-throughput cell biology. Read GenScript, a company that does everything from DNA synthesis to cell line manufacturing, increased revenue by 27.7% from 2021 to 2022, up to $625 million. Might be useful! Wiener D.M. Press release. Press release. ’” Fierce Biotech.

DNA 52

DNA RNA Engineering Licensing 52

BMG Labtech

MARCH 8, 2023

005 (inactive 31 December 2022). Alberts B, How Cells Obtain Energy from Food, Molecular Biology of the Cell (4th ed.). In Varki A, Cummings RD, Esko JD, Stanley P (eds.). Essentials of Glycobiology (3rd ed.). Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press. doi:10.1101/glycobiology.3e.005 PMID 28876856.

Molecular Biology 52

Molecular Biology Production Cell Based Assays DNA 52

DrugBank

JUNE 27, 2023

Genome.gov [link] (2022). Network expansion of genetic associations defines a pleiotropy map of human cell biology. The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource. Nucleic Acids Res. 51 , D977–D985 (2023).  The Cost of Sequencing a Human Genome.  Wright, S. Paulden, M. &

Disease 89

Disease Treatment Drugs DNA 89

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62