Remove 2022 Remove Cell Biology Remove DNA
article thumbnail

A different approach: reimagining biology

Drug Discovery World

Three key members of the team – Dr Raquel Sanches-Kuiper, Vice President of Technology, Dr Matthew Hayes, Chief Technology Officer and John Edgell, Head of Cloud Engineering – explain how the company is doing this and what it means for the advancement of DNA synthesis in the lab. The next goal is to optimise the technology. “At

DNA 130
article thumbnail

How to advance AAV-based gene therapies

Drug Discovery World

in Cell Biology and Biochemistry from University College London and was a post-doctoral fellow at Albert Einstein College of Medicine in New York City. Food & Drug Administration (2022) FDA Approves First Gene Therapy to Treat Adults with Hemophilia B. She received a Ph.D. References 1: U.S. Accessed 26 Jul 23.

Therapies 162
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Spider silk can stabilize cancer-suppressing protein

The Pharma Data

. “The problem is that cells only make small amounts of p53 and then quickly break it down as it is a very large and disordered protein,” says the study’s last author Michael Landreh, researcher at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet. 2022.02.013. Source link: [link].

article thumbnail

Who are the AACR Scientific Achievement Award winners?

Drug Discovery World

He is being recognised for his fundamental discoveries dedicated to characterising the genetic drivers of human B-cell lymphomas and for uncovering new avenues for cancer prevention and therapy that have been routinely exploited clinically to diagnose and determine novel therapeutic strategies for B-cell lymphoma.

article thumbnail

TACACICLIB, AUR-102, AURIGENE

New Drug Approvals

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

article thumbnail

Codon Digest: Injected Gene Editors

Codon

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. They tend to “group up” in cells. Molecular Systems Biology. Nature Microbiology. Meeussen J.V.W.

DNA 52
article thumbnail

Transforming high-throughput screening with mass spectrometry

Drug Discovery World

Lundblad, Drug Design, in Encyclopedia of Cell Biology (Volume 1), Elsevier, 2016. Büttner, MALDI-TOF mass spectrometry-based high-throughput screening for inhibitors of the cytosolic DNA sensor cGAS, SLAS Discovery, 2020, 25: 372–383, [link]. 22 timsTOF fleX MALDI-2, Bruker Daltonics, [link] [accessed 8 April 2022].