Drug Target Review

AUGUST 24, 2023

Her discoveries on the first-in-class RNA-based innate immune receptor agonist RGT100, built the foundation for the initiation of a Phase I clinical trial as well as the successful acquisition of Rigontec by MSD (known as Merck & Co. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62

Codon

APRIL 2, 2023

Read A new DNA polymerase variant, called RT-KTq I614Y, can directly detect RNA modifications, including pseudouridine (Ψ) and queuosine (Q). By combining this new variant with standard sequencing methods, it’s possible to identify RNA modifications in a really simple way. Communications Biology. Cell Systems.

DNA 52

DNA RNA Engineering Licensing 52

Drug Discovery World

OCTOBER 20, 2022

A limitation of conventional flow cytometry in the era of single cell biology is how many distinct pieces of information can be collected about each cell. Volume 23 – Issue 4, Fall 2022. Diversity and Biology of Cancer-Associated Fibroblasts. Elyada et al. References: Biffi G, Tuveson DA. Physiological Reviews.

Cell Based Assays 130

Cell Based Assays Therapies Cell Biology RNA 130

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). Synthesis.cc (2022).

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). Synthesis.cc (2022).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

APRIL 16, 2023

Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Nature Biotechnology.

Engineering 52

Engineering DNA RNA Science 52