Metabolite Tales Blog

APRIL 4, 2023

Metabolism of 2022 FDA approved small molecule drugs part 2 Mixing it Up By Julia Shanu-Wilson In Part 1 of this topic we looked at metabolism of the small molecule drugs approved by the FDA in 2022 that were mediated by CYP3A4. Drug metabolism in drug discovery and development.

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Metabolite Tales Blog

DECEMBER 13, 2023

N -glucuronidation: the human element By Julia Shanu-Wilson In our last blog of the year, we look at why N -glucuronidation of drugs is important in human drug metabolism. Glucuronidation is the most common phase II reaction observed in the metabolism of drugs in humans. Derun Li, David L. McGowan, Catherine White et al.

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Small Molecule Metabolic Stability Treatment Pharmacokinetics 59

Metabolite Tales Blog

MAY 12, 2023

In 2022, fewer of the 19 newly FDA approved small molecule drugs contained F atoms (adagrasib, lenacapavir, oteseconazole, vonoprazan), but this was followed by 3 more approvals of F-containing drugs in the first quarter of 2023 alone (pirtobrutinib, omaveloxolone, leniolisib). 2022), JBMR Plus, 6: e10557. Bennett, M.J.,

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Drugs Small Molecule FDA Approval Metabolic Stability 52

Practical Cheminformatics

JANUARY 2, 2024

2022 saw the emergence of deep learning (DL) methods for docking. In a brief section entitled “Predicting Protein-Small Molecule Complexes”, the authors mention their efforts to generate structures of bound non-covalent and covalent small molecule ligands. Experimentally Evaluating AlphaFold2 Structures 2.2

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Drugs Packaging Small Molecule Metabolic Stability 144