Drug Discovery World

NOVEMBER 27, 2023

In addition, it has stimulated increased collaboration among drug developers, technology providers, supply chain organisations, and regulators. Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production. Budge JD, Knight TJ, Povey J, et al.

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Production Engineering Molecular Biology Drug Development 147

Drug Discovery World

APRIL 17, 2024

Recently, research published by Dr Richard (Rick) Young (Whitehead Institute) describes the key mechanism of how these regRNAs regulate gene expression. So, regRNAs haven’t been exploited previously because scientists have only recently understood their role in regulating gene expression. Can you give some examples?

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Science RNA Disease Protein Expression 147

The Pharma Data

MARCH 23, 2022

The researchers found that Ebola virus polymerase leverages host protein GSPT1 to positively regulate viral transcription – a process the virus uses to convert its genetic material into instructions for making viral proteins. Cell Reports, 2022. “We weren’t expecting to see this,” says Fang.

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Virus Small Molecule Protein Production Research 52

Agency IQ

APRIL 12, 2024

BY RACHEL COE, MSC | APR 11, 2024 1:06 PM CDT Regulatory background: Product potency and assays As defined in statute , the FDA uses the term “potency” to refer to the “specific ability or capability” of a product to “effect a given result.” morphological cell changes or alterations in protein production or expression).

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Production FDA Therapies Biochemical Assays 40

Drug Discovery World

AUGUST 1, 2023

Also from Alnylam, in September 2022, the European Commission (EC) has granted marketing authorisation for the company’s AMVUTTRA (vutrisiran) for the treatment of hereditary transthyretin-mediated (hATTR) amyloidosis.

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RNA Vaccine Drugs Disease 130

Codon

MARCH 20, 2023

Self-regulating living material with temperature-dependent light absorption. Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast. Optogenetic closed-loop feedback control of the unfolded protein response optimizes protein production. Nature Communications. Science Advances.

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Virus Engineering RNA Small Molecule 52

Codon

MARCH 24, 2024

In response to this hysteria, regulation was aggressively tightened. In 2012, an Israeli company called Protalix gained approval for their plant-based enzyme product for Gaucher’s disease. Kanuma, their FDA-approved protein product for rare lysosomal diseases, is “purified from the egg white of transgenic hens.”

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