Metabolism of macrocyclic drugs
Metabolite Tales Blog
JULY 5, 2023
Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. Drug Hunter article, June 2023. Garcia Jimenez et al., 20 (March 20, 2014).
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