Drug Target Review

NOVEMBER 6, 2023

Advances in research and development and the utilisation of combination treatment strategies are revolutionising the haematology care landscape, but more must be done to address patients’ individual needs. These options are creating opportunities to develop more sophisticated, novel combination regimens for patients.

Small Molecule 111

Small Molecule Therapies Treatment Immune Response 111

Broad Institute

AUGUST 7, 2023

A surprising new role for a major immune regulator By Tom Ulrich August 7, 2023 Breadcrumb Home A surprising new role for a major immune regulator By Anne Trafton, MIT News August 7, 2023 Credit: RCSB Protein Data Bank A model of the human STING protein.

Regulations 91

Regulations Engineering Clinical Trials DNA 91

PLOS: DNA Science

JANUARY 4, 2024

.” CRISPRs are short DNA sequences, peppered with repeats, that latch onto DNA-cutting enzymes, commandeering and directing them to snip certain parts of a chromosome. The microbes deploy them to dismantle the genetic material of infecting viruses, a little like an immune response.

FDA Approval 52

FDA Approval DNA Clinical Trials Therapies 52

Drug Discovery World

APRIL 14, 2023

The American Association for Cancer Research (AACR) will honour the following cancer researchers, physician-scientists, advocates, and journalists during its annual meeting to be held April 14-19 at the Orange County Convention Center in Orlando, Florida. June’s award lecture will be held on Sunday April 16 at 4:30pm ET.

Clinical Trials 130

Clinical Trials Research Science Clinical Research 130

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 9 In addition, host immune responses further add to the complexity of developing cell-specific AAV capsids for clinical applications.

Engineering 105

Engineering Virus Therapies Immune Response 105

The Pharma Data

MAY 15, 2023

“The team at XinThera has developed research assets with the potential to target the DNA damage repair pathway in treating cancer and direct the body’s immune response in inflammatory diseases, both of which may improve outcomes for people living with these diseases,” said Flavius Martin, M.D.,

Small Molecule 40

Small Molecule DNA Immune Response Science 40

Drug Discovery World

JULY 31, 2023

Matt Hill , Founder and CEO of Elegen writes about the importance of innovation in DNA synthesis to address critical bottlenecks in biotherapy development. Regardless of the type of disease targeted, at the core of biotherapy development is synthetic biology and the use of synthetic DNA to programme specific behaviours within living cells.

DNA 130

DNA Vaccine Therapies Production 130

Drug Discovery World

NOVEMBER 13, 2023

On Day 3, Thursday 16 November 2023, the tracks include: the second part of machine learning for protein engineering, antibodies against membrane protein targets, engineering bispecific antibodies, next-generation immunotherapies, protein stability and formulation, and protein process development.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. The drugs work by blocking a protein, PD-1 — which helps keep immune responses in check — and stimulating the immune system to attack tumors.

Research 137

Research Immune Response Clinical Trials Cell Biology 137

Drug Discovery World

APRIL 12, 2023

The pharmaceutical firm also provided promising updates on mRNA-4157/V940, which targets different tumour types, at Moderna’s Vaccines Day on 24 March 2023 2. The first detailed results of the trial will be presented at the American Association for Cancer Research (AACR) in April 2023.

Vaccine 130

Vaccine Immune Response RNA DNA 130

Codon

SEPTEMBER 29, 2024

The first model of life emerged sometime in 2022 or 2023. There was scFormer in 2022, scGPT in 2023, and plenty of others. Reliance on mRNA had plenty of failure modes , but it was the most abundant source of cell-state data the scientific community had: DNA alone was static, and proteins were too hard to quantify en masse.

Engineering 125

Engineering Virus DNA Therapies 125

Agency IQ

APRIL 12, 2024

For therapeutic protein products , a critical use of assays is the detection and assessment of potential anti-drug antibody (ADA) formation, signaling a product’s potential to induce an unwanted immune response. Additionally, six of these comments came from the same organization (Integrated DNA Technologies).

Production 40

Production FDA Therapies Biochemical Assays 40

Drug Target Review

OCTOBER 4, 2023

The research community pressed on, turning to novel compounds that were substantially more potent than those used in the first generation. 2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads.

Small Molecule 126

Small Molecule Drugs Immune Response Targeted Protein Degradation 126

Drug Discovery World

AUGUST 1, 2023

In terms of partnerships and development , Orbit Discovery and start-up SanegeneBio have entered into a Master Service Agreement to identify tissue-specific delivery of a wide range of RNA therapeutics, as reported by DDW in January 2023. Though some genetic mutations are harmful, others can be protective.

RNA 130

RNA Vaccine Drugs Disease 130

Codon

FEBRUARY 13, 2024

Goodsell, RCSB Protein Data Bank and Scripps Research. Fast forward to 2023. 1 Yet even after more than two decades of research, media hype, and dozens of clinical trials and biotech start-ups that have come and gone, phage therapy has not scaled. Read it on our website here. Illustration by David S.

Therapies 118

Therapies Virus DNA Clinical Trials 118

Drug Discovery World

OCTOBER 17, 2023

BN : Expression analysis and imaging-based analyses have indeed been performed by completely separate groups of researchers so far, with little to no interaction between them. Spatial omics offers a new way of understanding these systems by providing a holistic view of healthy and diseased cells, pathogens, and the immune response.

Disease 130

Disease Small Molecule Drugs RNA 130

Drug Target Review

JANUARY 9, 2024

Presently, it is unknown how anthrobots encourage the growth of neurons, although the researchers confirmed that neurons grew under the area covered by a cluster of anthrobots, termed a “superbot.” 2004 July [2023 December 18]; 45(4):354-60. 1 The bots last a week before breaking down so can be reabsorbed into the body easily.

Laboratories 59

Laboratories Immune Response DNA Science 59

Drug Discovery World

FEBRUARY 2, 2023

The lead AdAPT candidate, AdAPT-001, in a Phase I/II clinical trial for the treatment of cancer, carries an extra piece of DNA called a transgene that binds to, traps, and neutralises a molecule called transforming growth factor-beta (TGF-b), which tumours hijack to suppress the antitumour immune response. Cell Mol Immunol.

Small Molecule 130

Small Molecule Clinical Trials Disease Therapies 130

The Anticancer Fund

MARCH 24, 2023

27 March 2023 Language EN Drug repurposing is a strategy for identifying new uses for approved drugs, outside the scope of the original indication. Our intention is to help bring these findings to the attention of the broader cancer research community. It is one of the focus areas of the Anticancer Fund.

Drugs 52

Drugs DNA Trials Treatment 52

Codon

APRIL 9, 2023

This is Codon Digest, my weekly roundup of research, news, and industry highlights about the future of biology. Thousands of transcription factors — proteins that bind DNA and control gene expression — were studied in human cells. Nucleic Acids Research. Nucleic Acids Research. Thank you for being here.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

MARCH 26, 2023

Nucleic Acids Research. Nucleic Acids Research. Link A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth. Link DNA storage in thermoresponsive microcapsules for repeated random multiplexed data access. Link CRISPR-induced DNA reorganization for multiplexed nucleic acid detection.

DNA 52

DNA Engineering RNA Science 52

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. Skin microbes can trigger strong immune responses. Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. coli DNA using a Retro-Cascorder. Please send me your feedback.

Engineering 52

Engineering DNA RNA Science 52