Codon

AUGUST 26, 2024

The Coalition for Epidemic Preparedness Innovations (CEPI)—a nonprofit organization that funds vaccine research and development—thinks so. Many research groups are now making broad-spectrum antivirals inspired by the innate immune system, leveraging recent advances in chemistry and biology. This work is already underway.

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RNA Virus DNA Vaccine 87

Drug Discovery World

APRIL 17, 2024

DDW’s Diana Spencer speaks to Josh Mandel-Brehm , CEO of Massachusetts-based biotech CAMP4, to understand the role regulatory RNAs play in gene expression and how the founders overcame the challenge of launching a business based on brand new science. DS: How easy was it to transfer theoretical research into a viable business?

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Science RNA Disease Protein Expression 147

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. The novel, hairpin-shaped molecule was named cabRNA for CBASS-activating bacteriophage RNA.

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RNA Immune Response DNA Molecular Biology 59

Broad Institute

JUNE 28, 2023

Marvin Caruthers By admin June 28, 2023 Breadcrumb Home Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers Dr. Marvin H. Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. For more information, visit [link].

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DNA RNA Vaccine Research 52

Broad Institute

DECEMBER 13, 2023

New method tags cells with location coordinates for single-cell studies By Corie Lok December 13, 2023 Breadcrumb Home New method tags cells with location coordinates for single-cell studies The technique, called Slide-tags, allows scientists to map the location of cells within tissues in standard single-cell experiments. By Sarah C.P.

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RNA DNA Research Hospitals 145

Drug Discovery World

AUGUST 29, 2024

For example, multiple RNA helicases are being targeted for cancer and viral infections before their catalytic properties are well understood. The company’s SimpleStep ELISA (SSE) kits are sandwich ELISA assays developed to cover over 900 key targets across research areas, including immunology, immuno-oncology and neuroscience.

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Small Molecule Drugs Protein Expression Assay Development 147

PLOS: DNA Science

MARCH 28, 2024

Research also took place in two facilities in Italy, with sponsorship from Italfarmaco S.p.A. million DNA bases. The exons are nestled amongst the much longer introns, which are DNA sequences that are not represented in the final protein. Researchers have been working on developing gene therapy for DMD for decades.

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FDA Approval Treatment FDA DNA 96

Drug Target Review

NOVEMBER 13, 2023

The instructions to form a cell are encoded in DNA strands, wrapped in proteins and RNA, and wound together into a 3D structure called chromatin. Researchers have long understood that Foxp3 is essential for regulatory T cell development, but only as an on-off switch for regulatory T cell genes.

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Government DNA Regulations RNA 104

Drug Discovery World

MARCH 7, 2023

In 2023, the company revealed data from a Phase III trial which showed that its vaccine candidate DCVax-L more than doubled overall survival in glioblastoma patients. Dr Janette Thomas, CEO, Five Alarm Bio Five Alarm Bio is an anti-ageing therapeutics company, which completed a seed investment round in early 2023.

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International Science Pharmaceuticals DNA 246

Drug Discovery World

SEPTEMBER 25, 2024

Additionally, the dynamic nature of tumour biology means that these targets can change over time, or under treatment pressure, necessitating continuous research and adaptation.” Stefan Ries is Chief Scientific Officer at DISCO Pharmaceuticals, a German company specialising in finding targets for targeted therapies such as ADCs.

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Therapies Pharma Companies FDA Approval FDA 162

Drug Target Review

SEPTEMBER 4, 2023

Infectious agents’ resistance was described at the European Union Research Parliament “as a widespread, multifaceted phenomenon that affects both living things and the environment, as well as their capacity to survive in the presence of drugs intended to either kill or inactivate them.”

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Drugs RNA DNA Disease 111

KIF1A

MAY 4, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. In this week’s article, researchers in Brazil identified a KIF1A mutation in a cohort of patients with congenital ataxia.

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Science Medical Schools RNA Research 116

Drug Discovery World

APRIL 16, 2023

The clinical benefit was observed regardless of the tumour mutational burden (TMB) status, according to results from the Phase IIb KEYNOTE-942 clinical trial presented at the AACR Annual Meeting 2023, held April 14-19. The post Personalised mRNA cancer vaccine prolongs survival in melanoma appeared first on Drug Discovery World (DDW).

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Vaccine Immune Response Medical Schools Trials 130

Drug Discovery World

JANUARY 21, 2024

Inspired by the overall event theme of ‘Innovation at Every Turn’, the DDW track will present leading research and case studies from experts in academia, government agencies and the industry on how technology is innovating from bench to bedside, lab to patient. It is sponsored by Integra Biosciences and Hamamatsu Corporation.

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Vaccine Computational Chemistry Animal Testing Engineering 130

The Open Targets Blog

AUGUST 15, 2023

Research in mice has shown that RBM3 expression is protective against misfolded protein damage, suggesting the protein as an interesting target in the development of therapies for neurodegenerative conditions such as Alzheimer’s disease. Where did the idea for this project come from? Was there anything surprising about your results?

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RNA Treatment Regulations DNA 52

Drug Discovery World

OCTOBER 16, 2023

Here, DDW’s Megan Thomas highlights the research taking place and where this is happening. This environment of research excellence, in turn, fosters R&D, innovation, spin-offs, start-ups, networking, collaboration and entrepreneurship, which sets a sturdy foundation that attracts funding, and creates an appealing work culture.

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Drugs Science Therapies Targeted Protein Degradation 189

Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. When the CDC contacted Harris to ask about the plague samples, Harris claimed that he was doing research for the CIA to stop an “imminent invasion from Iraq of super-germ-carrying rats.” This article concludes our mini-issue.

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DNA Bioinformatics Virus Government 80

Broad Institute

JUNE 28, 2023

By Leah Eisenstadt June 28, 2023 Credit: Courtesy of the Zhang lab Cryo-EM map of a Fanzor protein in complex with ωRNA and its target DNA. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells. said Zhang.

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RNA DNA Research Engineering 139

Drug Discovery World

AUGUST 1, 2023

1 August was first chosen as World RNA Day in 2018 as a play on AUG (adenine, uracil and guanine), a triple sequence of RNA (called a codon) that initiates protein synthesis by the cell. The company said: “Our preclinical research shows promising results that ASO treatment targeted to PNPLA3 reduces fat accumulation in liver cells.

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RNA Vaccine Drugs Disease 130

Drug Target Review

JUNE 6, 2023

Difficult-to-treat and rare, complicated cancers remain a perplexing challenge for IO researchers. Research has shown that these immune system proteins have the ability to trigger anti-cancer immune pathways. Currently he is Alkermes’ Oncology Fellow and Head of a Oncology Preclinical Research at the company. References: M; LWR.

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Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

Drug Discovery World

JULY 11, 2023

Now, with the growth of publicly available genomics, transcriptomics, and proteomics databases, the ability to quickly carry out large-scale DNA, RNA, and protein screenings, and the availability of massive sets of de-identified patient data, the amount of high-value, analysable data has reached enormous proportions.

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Science Drugs FDA Engineering 100

Drug Discovery World

JUNE 6, 2023

DDW’s Megan Thomas provides highlights from AACR 2023, the American Association of Cancer Research’s annual meeting from 14-19 April 2023 in Orlando, Florida, US. Fortunately, this is an organisation that’s committed to actually putting resources back into cancer research.

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Small Molecule DNA RNA Research 130

Drug Discovery World

NOVEMBER 13, 2023

On Day 3, Thursday 16 November 2023, the tracks include: the second part of machine learning for protein engineering, antibodies against membrane protein targets, engineering bispecific antibodies, next-generation immunotherapies, protein stability and formulation, and protein process development.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Drug Discovery World

AUGUST 8, 2023

DDW’s Megan Thomas takes a deeper look into why India is ramping up drug discovery research, and explores the country’s innovation hubs of interest. Outside of academia, there are institutions such as the CSIR- Central Drug Research Institute (CDRI), a multidisciplinary research laboratory in Lucknow 11.

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Research Pharmacy Pharmaceuticals Government 130

Drug Discovery World

NOVEMBER 30, 2023

DDW’s Megan Thomas attended PEGS Europe 2023 in Lisbon, Portugal, from Tuesday 14 November to Thursday 16 November 2023. The presentation introduced the company’s high-throughput expression systems, its approaches to organising data and its design approaches. kb Influenza A hemagglutinin gene was used as a model system.

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Protein Expression Engineering DNA Therapies 147

Broad Institute

NOVEMBER 23, 2023

By Allessandra DiCorato November 23, 2023 Credit: Jessica Hernandez, Broad Communications Related news Researchers uncover new CRISPR-like system in animals that can edit the human genome Microbial sequence databases contain a wealth of information about enzymes and other molecules that could be adapted for biotechnology.

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RNA DNA Engineering Science 135

Drug Discovery World

JANUARY 17, 2024

With oncology accounting for a third of pharma’s product pipeline, significant challenges include fierce competition, high research and development costs over, 10-15 years for clinical development, and pressures to rapidly meet the demand for new treatments 2-4.

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DNA Clinical Trials RNA Treatment 147

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. Years of development and fast-paced research have continued to unlock its potential, expanding how CRISPR can be used to treat, detect, and prevent common diseases such as cancer and Covid-19.

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Disease DNA RNA Therapies 246

Drug Target Review

SEPTEMBER 28, 2023

After that, I spent over a decade at a large instrument and genomics company working in, and then leading, research and development. Many people weren’t interested in the field and those that were familiar with it couldn’t see a path to building a billion-dollar business from DNA. Some of our best investors started as ‘no’s.

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DNA Organic Chemistry Science Virus 116

Drug Discovery World

APRIL 18, 2023

A combination of the PARP inhibitor olaparib (Lynparza) and the investigational ATR inhibitor ceralasertib showed clinical benefit in paediatric patients with solid tumours exhibiting DNA replication stress and/or DNA repair deficiencies, according to new data.

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Therapies DNA Trials RNA 130

Broad Institute

AUGUST 14, 2023

Three studies highlight how proteins are altered in multiple cancer types By Allessandra DiCorato August 14, 2023 Breadcrumb Home Three studies highlight how proteins are altered in multiple cancer types Researchers identify protein modifications that underlie many key cancer processes.

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DNA RNA Regulations Medical Schools 98

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. The researchers soon partnered with Calico Life Sciences , which in collaboration with AbbVie , discovered drug candidates that block the PTPN2 protein.

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Research Immune Response Clinical Trials Cell Biology 137

KIF1A

JANUARY 20, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. In this week’s article, researchers in Shanghai, China identified 6 children with KIF1A mutations and compared their symptoms to cases in the literature.

DNA 105

DNA RNA Disease Research 105

Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

Bioinformatics 287

Bioinformatics Pharmacogenetics RNA Medical Schools 287

Drug Discovery World

JUNE 18, 2024

In November 2023, the FDA issued a warning about a risk of secondary cancers that may be associated with CAR-T cell therapy. In the only case of fatal secondary T cell cancer, researchers found it was likely due to the immunosuppression caused by CAR-T cell therapy, rather than the CAR-T cells. “We in the three years after therapy.

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Therapies RNA DNA FDA 130

Drug Discovery World

APRIL 12, 2023

The pharmaceutical firm also provided promising updates on mRNA-4157/V940, which targets different tumour types, at Moderna’s Vaccines Day on 24 March 2023 2. The first detailed results of the trial will be presented at the American Association for Cancer Research (AACR) in April 2023.

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Vaccine Immune Response RNA DNA 130

PLOS: DNA Science

JUNE 29, 2023

Rather than attempting to image human embryos, researchers are tracking gene expression – that is, which genes a particular cell turns on or off at a particular time, providing a view of overall function. Women having abortions also donate embryos for research. The technique is called “RNA-Seq” for short.

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RNA DNA Bioethics Research 94