The Pharma Data

APRIL 11, 2023

Bayer is progressing novel research around its prostate cancer treatment darolutamide. Both small molecule inhibitors in Immuno-Oncology are being jointly developed in a strategic research alliance with the German Cancer Research Center (DKFZ) in Heidelberg, Germany.

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Drug Target Review

NOVEMBER 6, 2023

Advances in research and development and the utilisation of combination treatment strategies are revolutionising the haematology care landscape, but more must be done to address patients’ individual needs. To bring us closer to curing cancer, a combination of effective drugs with non-overlapping mechanisms of action is required.

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Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. 2011 January 1 [2023 November 21]; 1(1):31-45. But what, exactly?” Phages in nature.

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Drug Discovery World

AUGUST 10, 2023

ND : Totus has innovated three interdependent and fundamental technologies in chemistry, biology, and AI to enable screening of billions of candidate molecules against hundreds of targets in parallel. Second, we have created a novel DNA-tracking technology to analyse billions of molecular interaction in a cellular setting.

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The Pharma Data

MAY 15, 2023

Through the acquisition, Gilead gains rights to a portfolio of small molecule inhibitors targeting PARP1 for oncology and MK2 for inflammatory diseases that could enter clinical trials later this year. Executive Vice President, Research, Gilead Sciences. “The Executive Vice President, Research, Gilead Sciences.

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Drug Discovery World

OCTOBER 16, 2023

Here, DDW’s Megan Thomas highlights the research taking place and where this is happening. This environment of research excellence, in turn, fosters R&D, innovation, spin-offs, start-ups, networking, collaboration and entrepreneurship, which sets a sturdy foundation that attracts funding, and creates an appealing work culture.

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Drug Discovery World

JULY 11, 2023

Now, with the growth of publicly available genomics, transcriptomics, and proteomics databases, the ability to quickly carry out large-scale DNA, RNA, and protein screenings, and the availability of massive sets of de-identified patient data, the amount of high-value, analysable data has reached enormous proportions.

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Drug Discovery World

JUNE 6, 2023

DDW’s Megan Thomas provides highlights from AACR 2023, the American Association of Cancer Research’s annual meeting from 14-19 April 2023 in Orlando, Florida, US. Fortunately, this is an organisation that’s committed to actually putting resources back into cancer research.

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Drug Discovery World

NOVEMBER 13, 2023

On Day 3, Thursday 16 November 2023, the tracks include: the second part of machine learning for protein engineering, antibodies against membrane protein targets, engineering bispecific antibodies, next-generation immunotherapies, protein stability and formulation, and protein process development.

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KIF1A

MAY 31, 2024

Reflecting on a Remarkable Year: KIF1A.ORG’s 2023 Annual Report Dear KAND Community, Let’s take a moment to reflect on the incredible journey we’ve shared in 2023. To learn more about epilepsy and seizures, watch Dr. Tristan Sands’ talk from our community call in 2023.

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KIF1A

MAY 6, 2023

Each week, Dr. Dominique Lessard and Dr. Dylan Verden of KIF1A.ORG summarize newly published KIF1A-related research and highlight progress in rare disease research and therapeutic development. In this week’s article, researchers collected high resolution recordings of the kinesin-1 motor protein as it walked along the microtubule.

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Drug Target Review

OCTOBER 4, 2023

The research community pressed on, turning to novel compounds that were substantially more potent than those used in the first generation. 2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads.

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Drug Discovery World

OCTOBER 17, 2023

BN : Expression analysis and imaging-based analyses have indeed been performed by completely separate groups of researchers so far, with little to no interaction between them. RA: Will AI and computing advances help researchers better analyse data from spatial biology studies?

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Drug Discovery World

FEBRUARY 2, 2023

A variation on the master of none vs master of one theme is a single drug that targets several diseases (hence, master of many) but only inhibits a few targets; in the case of the small molecule known as RRx-001, those targets are subject to change depending on the local environmental conditions that are present in certain tissues or cells.

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KIF1A

JANUARY 27, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. Dr. Simran Kaur’s 2023 conference talk briefly describes the KIF1A mini-gene approach.

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Nvidia Developer: Drug Discovery

MARCH 21, 2023

New supercomputing-scale large language models (LLMs) that understand biology and chemistry text are helping scientists understand proteins, small molecules, DNA, and biomedical text. These state-of-the-art AI models help generate de novo proteins and molecules and predict the 3D structures of proteins.

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Codon

MARCH 20, 2023

Dates: March 13-20, 2023. Nucleic Acids Research. Marine biofilm engineered to produce current in response to small molecules. Digital nanoreactors to control absolute stoichiometry and spatiotemporal behavior of DNA receptors within lipid bilayers. Nucleic Acids Research. Nucleic Acids Research.

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Elrig

APRIL 29, 2024

Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing. There, I supported AI-enabled DD efforts in their small molecule portfolio.

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Alta Sciences

APRIL 17, 2024

Five Promising Treatment Areas in Early-Phase Drug Development in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drug development is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues. Asia, and Europe.

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Agency IQ

AUGUST 11, 2023

BY KARI OAKES AUG 7, 2023 10:20 PM CDT Quick background on nitrosamines in pharmaceutical products Nitrosamines are a large and diverse class of chemicals, with more than 300 different structurally distinct species known today. In a study of more than 12,000 small molecule drugs , researchers found 40.4%

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Agency IQ

APRIL 19, 2024

The most recent accelerated approvals occurred in August 2023: Elrexfio (elranatamab-bcmm; Pfizer) and Talvey (talquetamab-tgvs; Janssen). Note: Both analyses focused only on studies of small molecules, antibodies and biologics; studies of CAR T therapies were not included.

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Codon

MARCH 26, 2023

Link Single-molecule visualization of stalled replication-fork rescue by the Escherichia coli Rep helicase. Nucleic Acids Research. Nucleic Acids Research. Link A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth. Nature Communications. Molecular Cell. Nature Communications.

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The Premier Consulting Blog

APRIL 25, 2023

President Biden of the United States (US) has recently signed into law the Fiscal Year 2023 Omnibus Appropriations Bill, which included the FDA Modernization Act 2.0. In the US, new small molecule drugs are developed under the requirements of Sections 505(b)(1) and 505(b)(2) of the FFDCA.

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Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. It costs about $15 to sequence a DNA plasmid (if you use Plasmidsaurus ). coli DNA using a Retro-Cascorder. Mansilla S.F.

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