Drug Discovery World

FEBRUARY 13, 2024

Often this can be drug approvals, exciting research into hard-to-treat indications, or even regulatory updates that enable players within the sector to utilise the latest technologies and drive therapies to market faster, ultimately benefitting patients. appeared first on Drug Discovery World (DDW). Progress isn’t stagnant though.

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Drug Target Review

JULY 4, 2023

Over the last two decades, an increasing number of Antibody Drug Conjugate (ADC) therapeutics have been approved for oncology indications. These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. 3D rendering of Antibody Drug Conjugate Molecules.

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Small Molecule Drugs Clinical Pharmacology Trials 145

Drug Target Review

SEPTEMBER 25, 2024

However, this will not be straightforward, given that non-oncogene resistance is driven by complex transcriptional networks, and the key drivers that determine how these mechanisms could be targets for drug development remain elusive. This orally available small molecule binds to the bromodomain of CBP/p300 in a highly specific manner.

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Small Molecule Therapies Regulations Treatment 105

Drug Discovery World

FEBRUARY 22, 2023

Beyond 2023 we will also see even more sophisticated use of cloud computing, which will enable the pharma community to innovate rapidly, manage changes effortlessly and deliver new medicines faster.

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Drug Discovery World

MARCH 2, 2023

DDW is hosting an exclusive free event, Connected chemistry: How to choose the most promising drug candidates from your hit list. It will take place on March 8, 2023 3PM GMT. This free event is ideal for research scientists and managers working in small molecule drug discovery. Register here for free.

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Drug Discovery World

APRIL 6, 2023

The workshop will be led by hfp consulting, a firm which specialises in career development and leadership training for scientists. This session will take place during the meeting on Saturday, 15 April, 2023 at 11:45 PM – 3:45 PM EST. Location: Orange County Convention Center, Rooms W 340AB.

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Drug Discovery World

FEBRUARY 23, 2023

DDW is hosting an exclusive free event, Connected chemistry: How to choose the most promising drug candidates from your hit list. It will take place on March 8, 2023 3PM GMT. This free event is ideal for research scientists and managers working in small molecule drug discovery. Register here for free.

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Small Molecule Drugs Research Drug Development 130

Drug Discovery World

FEBRUARY 16, 2023

DDW is hosting an exclusive free event, Connected chemistry: How to choose the most promising drug candidates from your hit list. It will take place on March 8, 2023 3PM GMT. This free event is ideal for research scientists and managers working in small molecule drug discovery. Register here for free.

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Small Molecule Drugs Research Drug Development 130

Drug Discovery World

FEBRUARY 9, 2023

DDW is hosting an exclusive free event, Connected chemistry: How to choose the most promising drug candidates from your hit list. It will take place on March 8, 2023 3PM GMT. This free event is ideal for research scientists and managers working in small molecule drug discovery. Register here for free.

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Small Molecule Drugs Research Drug Development 130

Drug Discovery World

FEBRUARY 2, 2023

DDW is hosting an exclusive free event, Connected chemistry: How to choose the most promising drug candidates from your hit list. It will take place on March 8, 2023 3PM GMT. This free event is ideal for research scientists and managers working in small molecule drug discovery. Register here for free.

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Small Molecule Drugs Research Drug Development 130

Drug Discovery World

APRIL 12, 2023

This paid-for advertorial by IRBM appeared in DDW Volume 24 – Issue 2, Spring 2023 The landscape for treating rare cancers is changing with advances in molecular genetics, novel drug modalities and patient-derived models. Such insights are helping drug hunters to design novel drug development strategies.

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Drugs Small Molecule Treatment Drug Development 130

Broad Institute

NOVEMBER 2, 2023

Bayer and Broad Institute extend cancer therapy research collaboration By Corie Lok November 2, 2023 Breadcrumb Home Bayer and Broad Institute extend cancer therapy research collaboration Long-standing industry-academia collaboration has already resulted in three clinical oncology candidates.

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Therapies Research Small Molecule Clinical Trials 105

Drug Discovery World

JUNE 1, 2023

Antibody-drug conjugates (ADCs) are biopharmaceutical products in which a monoclonal antibody (mAB) is linked to a small molecule drug with a stable linker 1. This appears to be supported by the number of Chinese collaborations, approvals and expansions in 2023 alone.

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Marketing FDA Approval Licensing Licensing 245

Metabolite Tales Blog

APRIL 10, 2024

Where data was publicly available, the routes of human metabolism for each of the drugs in this subset is listed in Table 1. It is proposed that the decreased clearance of the drug observed in patients may be due to depletion of GSH in this population [10]. Drug Metab Dispos. 2023; 51(7):873-883. 2023; 62(12):1765-1779.

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Small Molecule FDA Approval FDA Pharmacokinetics 59

LifeSciVC

JANUARY 16, 2024

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Just in time for new years’ reflections and resolutions, this year’s JPM felt like a refreshing burst of enthusiasm for a sector that has seen its challenges in 2022 and 2023 but also some green shoots. Small molecule GLP1s?

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Small Molecule Trials Therapies Disease 139

Drug Discovery World

NOVEMBER 8, 2023

Harnessing AI, researchers have significantly expedited the drug discovery process, achieving what traditionally takes years in just 30 days. This method not only promises more efficient drug development but could also revolutionise clinical research and accelerate trials. NY Post 20 March 2023. Chem Sci 2023;14:1443-145.

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Clinical Trials Trials Disease Medical Schools 182

Drug Discovery World

FEBRUARY 27, 2023

For founders planning to launch their start-ups, specifically drug developers, there needs to be sound, foundational science with promising data that will enable you to push further down the drug discovery pipeline. Do you have any therapeutic targets in mind for your first small molecule drug candidate?

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PPD

OCTOBER 18, 2023

Continued expansion of the biotech industry is occurring in parallel, with an estimated compound annual growth rate of 13.96% from 2023-2030. 1 With this growth comes increased demands for laboratory services at all steps across the development process.

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Laboratories Assay Development Small Molecule Packaging 52

Drug Target Review

NOVEMBER 6, 2023

To bring us closer to curing cancer, a combination of effective drugs with non-overlapping mechanisms of action is required. 6 In all these examples, an effective backbone drug was first developed, before adding one or more drugs to establish the new regimens. link] Accessed October 2023. Accessed October 2023.

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Small Molecule Therapies Treatment Immune Response 111

PPD

JUNE 27, 2024

In recent years, AA has followed in the footsteps of other dermatology indications — including psoriasis and atopic dermatitis — with growing research and clinical studies focusing on small molecules with broad cellular effects (JAK and PDE4 inhibitors) and cytokine-specific molecules antagonists (IL-23, Th2 and IL17) to treat the condition.

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Treatment Clinical Trials Small Molecule Clinical Research 52

The Premier Consulting Blog

AUGUST 8, 2024

Typically, new drug development under the 505(b)(2) pathway requires less capital and time and has a higher success rate versus the 505(b)(1) pathway, where the Sponsor develops safety and effectiveness information from scratch. It can simply start with a strategic assessment of your drug product. [i] FDA-2023-N-2850.

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Pharmacokinetics FDA Production Drugs 52

Drug Discovery World

APRIL 25, 2023

The Autumn Statement in 2022 saw the UK Chancellor Jeremy Hunt cut the SME R&D tax relief rate, meaning SMEs would only receive half the cash co-investment from government they are expecting from April 2023 onwards, creating deficits in their future budgets. appeared first on Drug Discovery World (DDW).

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Drug Discovery World

OCTOBER 16, 2023

A company within this ecosystem is STORM Therapeutics, a clinical stage biotechnology company creating novel small molecule therapies that inhibit RNA modifying enzymes (RME) for use in oncology and other diseases. DDW Volume 24 – Issue 4, Fall 2023 The post Where is the drug discovery expertise happening in the UK?

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Drugs Science Therapies Targeted Protein Degradation 189

Sygnature Discovery

OCTOBER 10, 2023

On 10th October 2023, Sygnature Discovery, a world-leading integrated drug discovery provider and non-clinical solutions provider, has announced a scientific collaboration with human induced pluripotent stem cell (iPSC) experts, Axol Bioscience.

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Small Molecule Drugs Disease Clinical Trials 52

The Pharma Data

MARCH 28, 2022

Dupixent peak sales ambition raised to more than €13 billion Chronic obstructive pulmonary disease 2023 pivotal readouts provide potential for additional Dupixent sales ambition upgrade 13 potential new medicines currently in the clinic to treat chronic inflammatory diseases, with 17 readouts expected by the end of 2024.

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Small Molecule Clinical Development Disease Science 52

Drug Discovery World

JANUARY 26, 2023

DDW Editor Reece Armstrong takes a look at the pharmaceutical research and development market in 2023 and asks key opinion leaders what challenges and trends will emerge throughout the year.

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Clinical Trials Drugs Trials Therapies 246

Drug Discovery World

JULY 11, 2023

How AI and ML are influencing drug development Biopharma has experienced significant growth in using these technologies for the past 10 years. For example, Sanofi, Pfizer, Gilead, Novartis, BMS, Genentech, and Bayer have all announced significant alliances to integrate these big data technologies into drug discovery operations.

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Drug Discovery World

JANUARY 20, 2023

This paid-for advertorial by CN Bio appeared in the SLAS 2023 Supplement, Volume 24 – Issue 1, Winter 2022/2023 Despite advancements, the drug development process remains inefficient. OOC systems represent the next generation platform for predicting drug effects in humans. References DOI: 10.1016/j.apsb.2022.02.002

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Drug Development Drugs Small Molecule Immune Response 130

Drug Discovery World

APRIL 12, 2023

This paid-for advertorial by CN Bio appeared in DDW Volume 24 – Issue 2, Spring 2023 Despite advancements, the drug development process remains inefficient. Existing in vivo and in vitro models aren’t up to the challenge Preclinical tools exist for the evaluation and screening of potential drug candidates.

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Drug Development Drugs Small Molecule Immune Response 130

Vial

DECEMBER 11, 2023

Hepatitis C Virus (HCV) Drug Development There is an urgent need to develop novel, efficient, reliable, and cost-effective diagnostic technologies and therapeutic and immune prophylactic interventions to manage HCV. The Food and Drug Administration (FDA) approved and recommended dozens of small-molecule drugs.

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Clinical Research Therapies Research Vaccine 52

Drug Target Review

JULY 12, 2023

If there is robust gene expression data for the aspect of a disease that we are aiming to reduce or eliminate, the DCT mechanism will find results that can lead us to promising new drug candidates. We are pleased that to date our lead product candidate has aligned DCI profiles as expected.

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Biochemical Assays Treatment Bioinformatics Disease 98

Drug Discovery World

AUGUST 2, 2023

PPT1 inhibitors for the treatment of patients with cancer Contemplating the potential of PPT1 inhibition in cancer led to the development of small molecules with high PPT1 affinity and limited toxicity for clinical drug development. He previously developed a Phase I and translational unit at Gustave Roussy.

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Small Molecule Immune Response Clinical Trials International 130

Alta Sciences

APRIL 17, 2024

Five Promising Treatment Areas in Early-Phase Drug Development in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drug development is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues. Asia, and Europe.

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Drug Development Treatment FDA Approval Drugs 52

Agency IQ

APRIL 19, 2024

As the FDA’s Center for Drug Evaluation and Research (CDER) characterized it in a 2023 call for comments : “Evolving understanding of disease biology and molecular pharmacology, advancements in drug discovery, and growth in novel therapeutic platforms (i.e., many overlap with the goals of this latest initiative.

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Clinical Trials Trials Science FDA 40

Conversations in Drug Development Trends

MAY 30, 2024

This trend is on the rise despite recent disappointments with clinical trial outcomes, which have the potential to destabilize the industry in the short term regarding drug development strategy and optimal study designs. Initial approval in 2023: FDA, U.S. Then 1 packet to be used twice daily thereafter.

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Treatment Small Molecule Clinical Trials Therapies 81

Conversations in Drug Development Trends

APRIL 4, 2024

Since reaching full implementation on January 21, 2023, numerous regulatory bodies have adopted the ICH M10 standards. Stability Tests: For small molecule, only -20°C stability testing is required, while large molecule need both -20°C and -70°C tests if samples are intended for storage at these temperatures.

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Drug Discovery World

OCTOBER 17, 2023

BN : Cell culture will remain important for drug screening and for understanding the basic mechanisms of action for therapeutics, but it lacks the complexity and spatial organisation of true tissues. This limits its efficacy in later stages of drug development or in the discovery and characterisation of biomarkers.

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