This site uses cookies to improve your experience. By viewing our content, you are accepting the use of cookies. To help us insure we adhere to various privacy regulations, please select your country/region of residence. If you do not select a country we will assume you are from the United States. View our privacy policy and terms of use.

Remove 2023 Remove Metabolic Stability Remove Process Chemistry Remove Trials
article thumbnail

Metabolism of macrocyclic drugs

Metabolite Tales Blog

JULY 5, 2023

Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. Journal of Medicinal Chemistry, 66 (8), 5377-5396. Journal of Medicinal Chemistry 62 (21), 9418-9437.

Metabolic Stability 52
Metabolic Stability Drugs FDA Approval Treatment 52
article thumbnail

Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

JULY 5, 2023

Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Not only this, the reduction in rotatable bonds and consequent reduction in susceptibility to metabolism is an additional benefit [4]. Journal of Medicinal Chemistry, 66 (8), 5377-5396. Journal of Medicinal Chemistry 62 (21), 9418-9437.

Metabolic Stability 52
Metabolic Stability Drugs FDA Approval Treatment 52
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

 

Stay Connected

Join 15,000+ Insiders by signing up for our newsletter

About
About
Editions
Editions
Topics
Powered by Aggregage | Terms and Conditions | Your California Rights and Privacy Policy
© Aggregage 2024