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Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry

Drug Hunter

Interestingly, among the six case studies, none use the well-known Hoveyda-Grubbs II (HG-II) catalyst in the largest scale synthesis disclosed, though several employ HG-II derivatives, highlighting the rapid evolution of catalytic methods and distinct considerations for process chemistry. 2023 , 66 , (8), 5377-5396. Kihlberg, J.

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Process Chemistry Unleashed: A 'Fit-for-Purpose' Approach to Accelerate IND Filing

Fierce BioTech

Process Chemistry Unleashed: A 'Fit-for-Purpose' Approach to Accelerate IND Filing pesurya Thu, 07/27/2023 - 11:27 Tue, 09/05/2023 - 10:00 Resource Type Webinar Qixuan Lu Duration 60 Minutes Process chemistry plays a pivotal role in various stages of the pharmaceutical R&D cycle.

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Welcome to new Director David Hulcoop

The Open Targets Blog

David Hulcoop, previously Strategy and Operations Director for the consortium, starts as Executive Director of Open Targets in October 2023. This involves scaling up the process of making a few grams of the compound in the lab to hundreds of tonnes in a factory, in an environmentally-friendly, cost-effective way.

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Metabolism of macrocyclic drugs

Metabolite Tales Blog

Journal of Medicinal Chemistry, 66 (8), 5377-5396. Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry. Drug Hunter article, June 2023. References [1] Macrocycles in Drug Discovery─Learning from the Past for the Future.

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Metabolism of de novo designed macrocyclic drugs

Metabolite Tales Blog

Journal of Medicinal Chemistry, 66 (8), 5377-5396. Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry. Drug Hunter article, June 2023. References [1] Macrocycles in Drug Discovery─Learning from the Past for the Future.