The Open Targets Blog

SEPTEMBER 21, 2023

David Hulcoop, previously Strategy and Operations Director for the consortium, starts as Executive Director of Open Targets in October 2023. This involves scaling up the process of making a few grams of the compound in the lab to hundreds of tonnes in a factory, in an environmentally-friendly, cost-effective way.

Organic Chemistry 83

Organic Chemistry Process Chemistry Small Molecule Science 83

Metabolite Tales Blog

JULY 5, 2023

A combination therapy of glecaprevir and pibrentasvir has recently been implicated in a case of liver injury. Figure 2 Human metabolism of glecaprevir Involvement of gut bacteria Grazoprevir (MK5172) is also used as part of combination therapy to treat chronic hepatitis C. Journal of Medicinal Chemistry, 66 (8), 5377-5396.

Metabolic Stability 52

Metabolic Stability Drugs FDA Approval Treatment 52

Metabolite Tales Blog

JULY 5, 2023

A combination therapy of glecaprevir and pibrentasvir has recently been implicated in a case of liver injury. Figure 2 Human metabolism of glecaprevir Involvement of gut bacteria Grazoprevir (MK5172) is also used as part of combination therapy to treat chronic hepatitis C. Journal of Medicinal Chemistry, 66 (8), 5377-5396.

Metabolic Stability 52

Metabolic Stability Drugs FDA Approval Treatment 52