The Open Targets Blog

SEPTEMBER 21, 2023

David Hulcoop, previously Strategy and Operations Director for the consortium, starts as Executive Director of Open Targets in October 2023. This involves scaling up the process of making a few grams of the compound in the lab to hundreds of tonnes in a factory, in an environmentally-friendly, cost-effective way.

Organic Chemistry 83

Organic Chemistry Process Chemistry Small Molecule Science 83

Metabolite Tales Blog

JULY 5, 2023

Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Journal of Medicinal Chemistry, 66 (8), 5377-5396. Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry. Garcia Jimenez et al.,

Metabolic Stability 52

Metabolic Stability Drugs FDA Approval Treatment 52

Metabolite Tales Blog

JULY 5, 2023

Still, of the 34 macrocycles currently in clinical trials, only 18% are de novo designed. Journal of Medicinal Chemistry, 66 (8), 5377-5396. Journal of Medicinal Chemistry 62 (21), 9418-9437. link] [4] Macrocyclization via Ring-Closing Metathesis in Drug Discovery & Process Chemistry. Garcia Jimenez et al.,

Metabolic Stability 52

Metabolic Stability Drugs FDA Approval Treatment 52