Drug Discovery World

APRIL 17, 2024

DS: CAMP4 leverages research from co-founder Richard Young on how regulatory RNA (regRNA) molecules control the expression of genes. JMB: Regulatory RNAs (or regRNAS) are molecules that directly control the expression of nearby protein-coding genes. DS: How easy was it to transfer theoretical research into a viable business?

Science 147

Science RNA Disease Protein Expression 147

Drug Discovery World

NOVEMBER 13, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Ali Madani, PhD, Founder and CEO, Profluent Bio, on: ‘Protein engineering with large language models’.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Agency IQ

APRIL 12, 2024

BY RACHEL COE, MSC | APR 11, 2024 1:06 PM CDT Regulatory background: Product potency and assays As defined in statute , the FDA uses the term “potency” to refer to the “specific ability or capability” of a product to “effect a given result.” morphological cell changes or alterations in protein production or expression).

Production 40

Production FDA Therapies Biochemical Assays 40

Drug Discovery World

MARCH 6, 2024

Mutations in a gene may cause structural changes in its protein product, which can lead to a loss of function and consequently to the onset of a disease. Mutations in the dark genome affect gene regulation rather than coding, exerting a positive or negative impact on the expression of genes that may be related to disease processes.

Clinical Trials 162

Clinical Trials Pharmaceutical Companies Disease Trials 162

Drug Discovery World

AUGUST 1, 2023

As per a definition provided by AstraZeneca: “Once inside, ASOs bind with high specificity to target mRNA or pre-mRNA, inducing its degradation – effectively silencing it – to prevent its translation into a detrimental protein product. Though some genetic mutations are harmful, others can be protective.

RNA 130

RNA Vaccine Drugs Disease 130

Codon

MARCH 20, 2023

Dates: March 13-20, 2023. 🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. The molecular grammar of protein disorder guiding genome-binding locations. Nucleic Acids Research. Self-regulating living material with temperature-dependent light absorption. O’Neill P.

Virus 52

Virus Engineering RNA Small Molecule 52

Broad Institute

JUNE 29, 2023

Williams June 29, 2023 Credit: Zeng H, Huang J, Ren J, et al. Now, researchers at MIT and the Broad Institute of MIT and Harvard have developed RIBOmap, a technique that lets them pinpoint and visualize the precise locations of thousands of proteins being produced within an intact tissue and even individual cells. By Sarah C.P.

Protein Production 105

Protein Production RNA Regulations Science 105