KIF1A

SEPTEMBER 23, 2023

While we usually think of this cause as KIF1A mutations, upstream regulators of motor proteins can also disrupt traffic. In a recent pre-print*, the Holzbaur Lab at University of Pennsylvania investigated how a protein called LRRK2 regulates the traffic of synaptic vesicle precursors, a type of KIF1A cargo. What’s a pre-print?

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FDA Law Blog: Biosimilars

JULY 6, 2023

By Véronique Li, Senior Medical Device Regulation Expert — Earlier this year, neither the Quality System Regulation (QSR) nor the Quality Management System Regulation (QMSR) were referenced in the semiannual regulatory agenda. In fact, the priority designation for the final rule is labeled as “economically significant.”

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Perficient: Drug Development

OCTOBER 24, 2024

Artificial intelligence (AI) is poised to affect every aspect of the world economy and play a significant role in the global financial system, leading financial regulators around the world to take various steps to address the impact of AI on their areas of responsibility.

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KIF1A

OCTOBER 7, 2023

These molecules regulate neuronal growth and survival, and mice with insufficient KIF1A show NTRK1 transport defect and reduced pain sensitivity. WNK1: WNK1 is a kinase that interacts with KIF1A and may regulate its ability to unload cargo at axon tips. SCN9A/Nav1.7: Genetic mutations among HSAN/Congenital Insensitivity to Pain cohort.

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Agency IQ

OCTOBER 27, 2023

What we expect European regulators to do in November 2023 In this new recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more.

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Agency IQ

DECEMBER 1, 2023

What we expect EU regulators to do in December 2023 Welcome to AgencyIQ’s monthly roundup of EU chemical sector activities. Highlights of chemical regulatory activities Consultations open under the REACH and CLP regulations are coming to an end in December. Events happening next month include two ECHA meetings (i.e.,

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Agency IQ

AUGUST 9, 2024

By Scott Stephens, MPA The European Commission plans to implement exemptions introduced under the Stockholm Convention’s 2023 ban of UV-328, an ultraviolet-light absorbing persistent organic pollutant (POP).

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KIF1A

JULY 8, 2023

KIF1A-Related Research Preferential transport of synaptic vesicles across neuronal branches is regulated by the levels of the anterograde motor UNC-104/KIF1A If axons are the highways KIF1A drive on, synapses are like the off-ramps and intersections for local deliveries. From Vasudevan et al. What’s a pre-print?

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Agency IQ

DECEMBER 1, 2023

What we expect European regulators to do in December 2023 In this new recurring feature, AgencyIQ, through public data and previous analysis, determines what European medicine and device regulators will likely do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods, and more.

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KIF1A

OCTOBER 21, 2023

But what regulates the delivery of materials at these early stages? In this week’s article, researchers investigated KIF1A’s role in the delivery of synaptic building blocks, and its regulation by the lipid (fat molecule) PI(3,5)P2. Read the Article The post #ScienceSaturday: October 21, 2023 appeared first on KIF1A.

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KIF1A

SEPTEMBER 16, 2023

But once a protein is made, it can still be regulated by making additions or modifications to its structure; these post-translational modifications could be useful tools for altering a protein’s behavior in a directed way, an approach closely related to structure-based therapeutics.

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Agency IQ

SEPTEMBER 15, 2023

PFAS regulation in California (late 2023 edition) California consistently maintains its status as both one of the most important economies in the world as well as one of the most regulated states in the United States. In 2019, the state began to significantly ramp up its PFAS regulation and research.

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Agency IQ

OCTOBER 27, 2023

What we expect EU regulators to do in November 2023 Welcome to AgencyIQ’s roundup of upcoming regulatory activities in the EU chemicals sector. Regulation on detergents and surfactants The expert working group on detergents is scheduled to hold a meeting on November 17.

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thought leadership

NOVEMBER 14, 2023

On October 3rd, 2023, the U.S. If implemented, this rule would result in LDTs generally falling under similar enforcement regulations as other in vitro diagnostic (IVD) products, a significant change from existing policy.

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KIF1A

JUNE 10, 2023

CX32 likely regulates this cooperation, as knocking down CX32 weakened the connection between SFXN-1.2 From Barmaver and Wagner (pre-print, 2023) In the figure above we see KIF1A, SFXN-1.2, But this landmark in gene editing regulation will tell us more about the FDA’s approach to gene therapies.

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KIF1A

SEPTEMBER 9, 2023

2023 There were also discrepancies between Nup153 and KIF1A knockdowns that are worth further investigation: For example, Nup153 knockdown, but not KIF1A knockdown, caused RGPs to stall during cell division, indicating that Nup153 could be regulating other proteins at the nucleus. Falnikar et al. What’s a pre-print?

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FDA Law Blog: Biosimilars

SEPTEMBER 11, 2023

Baumhardt, Senior Medical Device Regulation Expert & Adrienne R. Lenz, Principal Medical Device Regulation Expert — On September 6, 2023, FDA announced its latest efforts to modernize the 510(k) process, outlining FDA’s latest improvements to strengthen the 510(k) Program and announcing release of three draft guidance documents.

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KIF1A

JUNE 24, 2023

J Cell Biol 7 August 2023; 222 (8): e202208121. Rather than binding to kinesins directly, zinc binds to the microtubule, displacing other proteins that regulate the movement of kinesins. Read the Article The post #ScienceSaturday: June 24, 2023 appeared first on KIF1A. Minckley et al. How does zinc inhibit cargo transport?

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Agency IQ

JULY 22, 2024

The 103 regulations the EPA is currently working on On July 5, 2024, the EPA published its Spring 2024 Unified Agenda, which reveals what regulations the agency is planning on releasing by the end of the year and beyond.

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Agency IQ

DECEMBER 1, 2023

Welcome to AgencyIQ’s monthly roundup of EU chemical sector activities. This ongoing feature compiles information from across EU agencies and institutions to deliver an overview of chemicals-related regulatory actions likely to happen in the month ahead, including planned legislation, consultations, webinars, meetings, and more.

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The Premier Consulting Blog

OCTOBER 30, 2024

With extensive experience in manufacturing techniques and regulations, the CMC services team at Premier Consulting can help sponsors navigate the development of advanced manufacturing technologies. FDA Guidance, Advanced Manufacturing Technologies Designation Program , December 2023, [link] [link]

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Agency IQ

OCTOBER 27, 2023

Welcome to AgencyIQ’s roundup of upcoming regulatory activities in the EU chemicals sector. This ongoing feature compiles public information from across the EU to deliver an overview of all the chemical policy-related actions in the month ahead, including planned legislation, consultations, webinars, meetings, and more.

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KIF1A

OCTOBER 28, 2023

Other genes with potential links to KIF1A were also identified: LRRK2 is a Parkinson’s Disease-associated regulator of KIF1A cargo binding; and NEFH ‘s C. See the Tournament Page The post #ScienceSaturday: October 28, 2023 appeared first on KIF1A. elegans counterpart may stabilize KIF1A transport along microtubules.

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Agency IQ

AUGUST 9, 2024

Commission proposes exemptions to UV-328 ban under POPs Regulation The European Commission plans to implement exemptions introduced under the Stockholm Convention’s 2023 ban of UV-328, an ultraviolet-light absorbing persistent organic pollutant (POP). Some Annex C entries are repeated from Annex A.

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Broad Institute

AUGUST 7, 2023

A surprising new role for a major immune regulator By Tom Ulrich August 7, 2023 Breadcrumb Home A surprising new role for a major immune regulator By Anne Trafton, MIT News August 7, 2023 Credit: RCSB Protein Data Bank A model of the human STING protein. Online August 3, 2023. Paper Cited Liu B, Carlson R, et al.

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Covalent Modifiers

MARCH 1, 2024

CHANG Science 2023 382, 6670 DOI: 10.1126/science.abp9201 INTRODUCTION One-carbon metabolism manages cellular carbon pools by detoxifying highly reactive carbon species, such as aldehydes, and diverting their carbon toward the biosynthesis of useful products, including amino acids and nucleotides. DINGLER, CHRISTOPHER L. GARCIA-PRIETO MIA C.

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Agency IQ

JUNE 16, 2023

The 51 regulations that FDA is currently working on The FDA today unveiled its much-anticipated Spring 2023 Unified Agenda, a document outlining the regulations the agency plans to release in 2023 and beyond.

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KIF1A

JUNE 3, 2023

2023 This study has a small sample size from a single hospital, and there were patients who did not have available genetic data, so we can’t generalize these statistics too much. Read the Article The post #ScienceSaturday: June 3, 2023 appeared first on KIF1A. Genes associated with Pure and Complex HSP. Ikeda et al.

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Agency IQ

AUGUST 30, 2024

What we expect EU chemical regulators to do in September 2024 Welcome to AgencyIQ’s monthly roundup of EU chemical sector activities. A full list of chemical events is also scheduled for September, as regulators and regulatory affairs professionals return to work after the summer holidays.

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KIF1A

JUNE 17, 2023

They will be presenting at our 2023 Family and Scientific Engagement Conference ! Read the Article The post #ScienceSaturday: June 17, 2023 appeared first on KIF1A. Want to learn more about NeuCyte’s work?

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Agency IQ

AUGUST 2, 2024

What we expect EU chemical regulators to do in August 2024 Welcome to AgencyIQ’s monthly roundup of EU chemical sector activities. Other consultations ending in August include two addressing potential candidates for substitution and exemption conditions under the Biocidal Products Regulation (BPR), including for the substance DBNPA.

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Agency IQ

MARCH 29, 2024

National PFAS water regulations imminent The White House Office of Information and Regulatory Affairs has cleared a final rule that will implement the first national drinking water regulations for per- and polyfluoroalkyl substances. The rule, once released, will set the tone for future PFAS regulation in the U.S. with the U.S.

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Perficient: Drug Development

SEPTEMBER 6, 2023

The regulators feel that this proposed LTD rule would: Improve the resolvability of these banking organizations in case of failure, Potentially reduce costs to the Deposit Insurance Fund, and Mitigate financial stability and contagion risks by reducing the risk of loss to uninsured depositors.

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Eye on FDA

FEBRUARY 8, 2024

If you factor out the FDA Roundups from the number for 2023, then the agency only sent out 102 traditional press releases. The number of releases in relation to new gene therapies increased from 3 to 5, however it is worth noting that one of the 2023 releases actually addressed the approval of 2 new gene therapies in one release.

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KIF1A

JULY 1, 2023

This activity may be regulated by the K-loop, which is known to be important for KIF1A’s long-range movement. Read the Article The post #ScienceSaturday: July 1, 2023 appeared first on KIF1A. By interacting with the microtubule, the tethered head may keep KIF1A from detaching mid-stride.

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KIF1A

MAY 27, 2023

I am excited to attend the upcoming 2023 KAND Family and Scientific Engagement Conference in person, that will enable our community to reflect upon the progress and to design the next steps to address the KAND therapeutic development challenge collaboratively. What’s a pre-print?

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KIF1A

NOVEMBER 20, 2023

The survey is available here: [link] Please complete the survey by December 18, 2023. Donate The post November 2023 Highlights appeared first on KIF1A. Dr. Dylan Verden at conferences~ Dr. Dylan Verden attended the Society for Neuroscience conference this year on behalf of our community! KIF1A’s C.

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