Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. Like Cas9, ZFPs can serve as guide proteins to direct the tool to a target site in DNA. Online June 27, 2024. Credit: Neumann EN, Bertozzi TM, et al.

Disease 142

Disease Therapies Clinical Trials Engineering 142

Codon

JULY 21, 2024

It may seem that if researchers are sufficiently concerned about the welfare of lab animals, the best thing to do would be to stop using animals altogether. However, a multitude of factors—from institutional inertia to a global animal-testing industry worth billions of dollars —make this outcome unlikely.

Research 119

Research Engineering Disease Science 119

Drug Target Review

SEPTEMBER 10, 2024

To achieve an aggressive timeline from DNA to investigational new drug (IND) application, drug developers have strengthened collaborations with contract development & manufacturing organisations (CDMOs) to expedite drug development. FDA no longer has to require animal testing for new drugs. References: 1 Wadman M.

Drug Development 65

Drug Development Clinical Supply Production FDA 65

PLOS: DNA Science

APRIL 4, 2024

.” But, tellingly, “Neither the law nor FDA regulations require specific tests to demonstrate the safety of individual products or ingredients.” It debuted in January 2024 , but the company has been around since 2015. ” Manufacturers can use existing safety data on each ingredient and on similar products.

Disease 92

Disease Production Testimonials FDA 92

Codon

NOVEMBER 1, 2024

Though my focus in this essay is narrow — I don’t discuss bottlenecks in clinical trials, human disease, or animal testing — I hope others will take on these challenges in similar essays. Perhaps you’ve seen this chart before, which shows the falling costs of DNA sequencing over the last two decades.

DNA 114

DNA RNA Molecular Biology Laboratories 114