Covalent Modifiers

FEBRUARY 25, 2024

2024 , DOI: 10.1039/D3CB00230F N6-Methyladenosine (m6A) is the most prevalent mRNA modification and is required for gene regulation in eukaryotes. Moreover, TD19 displays good anticancer efficacy in acute myeloid leukemia and glioblastoma multiforme cell lines.

RNA 157

RNA Cell Based Assays Regulations Research 157

Alta Sciences

SEPTEMBER 27, 2024

For example, ELISA and multiplexed assays are used for quantifying proteins or cytokines, ELISpot is ideal for detecting antigen-specific T-cell responses, flow cytometry helps assess cell populations and functions, and cell-based assays are essential for evaluating the functional activity of immune cells.

Clinical Trials 52

Clinical Trials Trials Pharmacokinetics Small Molecule 52

Drug Target Review

OCTOBER 24, 2024

Data-driven discovery As with many early-stage biotech companies, Five Alarm Bio is highly data-driven, producing vast amounts of experimental data through cell-based assays and phenotypic screening. cited 2024 Oct 17]. Reference 1 Five Alarm Bio.

Cell Based Assays 52

Cell Based Assays Science Disease Doctors 52

Molecular Design

DECEMBER 31, 2023

The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.

Drugs 96

Drugs Packaging Cell Based Assays Small Molecule 96

Elrig

APRIL 29, 2024

This involved designing and implementing biological strategies, encompassing target validation, hit identification, establishing assays, and collaborating on structural work. Joining Isomorphic Labs in October 2024, I’m thrilled to be part of their mission to revolutionize DD through AI/ML.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Molecular Design

MARCH 26, 2024

With apologies to Manfred Eigen (1927 - 2019) I've just returned to Cheshire from the Caribbean and, to kick off blogging from 2024 I'll share a photo of the orchids at Berwick-on-Sea on the north coast of Trinidad. We have to make assumptions in these situations and we also need to check that these assumptions are reasonable.

Drugs 60

Drugs Pharmacokinetics Cell Based Assays Treatment 60

Agency IQ

APRIL 12, 2024

Draft guidance on potency assays for CGT products garners extensive stakeholder input Late last year, the FDA published a draft update to its 2011 guidance on potency assays for cell and gene therapy products, unveiling a major shift in approach to the issue.

Production 40

Production FDA Therapies Biochemical Assays 40