Remove 2024 Remove Cell Based Assays Remove Small Molecule
article thumbnail

Inside The Altascientist Issue 41: Immunomodulation Assessments for Clinical Trials–Sophisticated Bioanalytical Approaches to Support Complex Modalities

Alta Sciences

The growing understanding of the immune system's role in various diseases, along with advancements in drug development, have led to a natural evolution from traditional vaccines, small molecules , and cytokines , to increased targeted biologics and innovative approaches in gene therapy and vaccines.

article thumbnail

Chemical con artists foil drug discovery

Molecular Design

The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.

Drugs 96
article thumbnail

AI At The Frontier: Empowering Early Career Professionals In Drug Discovery

Elrig

There, I supported AI-enabled DD efforts in their small molecule portfolio. This involved designing and implementing biological strategies, encompassing target validation, hit identification, establishing assays, and collaborating on structural work.