Drug Discovery World

JULY 23, 2024

3D genome folding DNA within the cell nucleus is more than the simple linear thread of primary sequence; it is tightly packed and folded non-randomly in a cell-type specific manner. Thus, most disease-associated regions (~95%) are found in the non-coding human genome, and a large proportion of these carry the hallmarks of enhancers 1.

DNA 130

DNA Disease Regulations Molecular Biology 130

LifeSciVC

AUGUST 5, 2024

But that initial quote isn’t from 2024, it is from an interview in 2021 with Mark Levin, CEO at Millennium (MIT Technology Review). In fact, it increased the requirement for experienced biologists to use the new genomic information and combine it with mechanistic biology to derive new therapeutic insights. One final parallel to 2001.

Molecular Biology 88

Molecular Biology Production Small Molecule Drug Development 88

Alta Sciences

MARCH 1, 2024

Norbert Makori and Pierre Jolicoeur: The Benefits of Combining Preclinical and Bioanalytical for Your Gene Therapy Studies pmjackson Fri, 03/01/2024 - 22:20 Recent advances in gene therapy have allowed for diseases to be approached differently.

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

Alta Sciences

AUGUST 21, 2024

Internships at Altasciences: Q&A With Our Summer Interns nbartlett Thu, 08/22/2024 - 04:44 Internships at Altasciences are more than just a stepping stone—they’re a gateway to real-world-experience and professional growth, giving the next generation opportunities to help shape progress in the drug development industry.

International 40

International Laboratories Science Molecular Biology 40

Drug Discovery World

APRIL 30, 2024

Whilst research into mRNA has been ongoing for decade, interest has sparked in recent years and research has begun to expand into areas of vaccinology, infectious diseases and other indications. If the body fails to make the right protein, diseases such as cancer, type II diabetes, neurological conditions, and metabolic diseases can occur.

Therapies 130

Therapies RNA Vaccine Small Molecule 130

Drug Discovery World

NOVEMBER 9, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Klaus Wagenbauer, PhD, Founder & CEO, Plectonic, on: ‘Programmable DNA-origami-based T cell engagers: PTE’.

Engineering 130

Engineering Therapies Protein Production Science 130

Codon

FEBRUARY 13, 2024

alone, according to the Centers for Disease Control and Prevention. Some algorithms simply look for important similarities between phage and bacterial DNA sequences, a signal of the extensive gene-swapping that goes on when a particular virus and bacteria have shared history. The tech for this process already exists.

Therapies 118

Therapies Virus DNA Clinical Trials 118