Drug Target Review

JANUARY 26, 2024

These ACE2-coated particles could be tested as an anti-viral therapeutic, and as sensors for detecting virus particles. To find a DNA fragment that contained the intact ACE2 gene, complete with its embedded regulatory information, they searched libraries of cloned DNA fragments generated as part of the Human Genome Project.

Production 114

Production DNA Virus Protein Expression 114

Drug Discovery World

FEBRUARY 28, 2024

Using a technique they’ve dubbed ‘cancer shredding’, the researchers at Gladstone Institutes, California, programmed CRISPR to zero-in on repeating DNA sequences present only in recurrent tumour cells – and then obliterate those cells by snipping away at them. Research into new cancer drugs remain strong.

Drug Development 162

Drug Development Research Clinical Trials Drugs 162

Drug Discovery World

JANUARY 21, 2024

Most drugs under development today are designed to do the same thing: inhibit the function of proteins that contribute to disease. But this strategy misses a vast therapeutic opportunity: addressing the many diseases that are caused by insufficient levels or impaired function of otherwise beneficial proteins,” Bushell explains. “By

Vaccine 130

Vaccine Computational Chemistry Animal Testing Engineering 130

Drug Discovery World

FEBRUARY 6, 2024

Auransa, which harnesses available data to discover highly intractable diseases with poorly understood biology. Pharos iBio, which utilises AI technology to develop treatments for refractory and rare diseases such as cancers and repurpose existing therapies. Obulytix is not alone.

Marketing 173

Marketing Laboratories Engineering Clinical Trials 173

Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. A concerned employee at a laboratory supply company had called the Centers for Disease Control, or CDC, after fielding repeated calls from Harris asking when his samples of plague would arrive in the mail. This article concludes our mini-issue.

DNA 85

DNA Bioinformatics Virus Government 85

Drug Discovery World

FEBRUARY 14, 2024

While a typical chemisty, manufacturing and controls (CMC) timeline from DNA to Investigational New Drug (IND) application in 2015 would have been approximately 24 months, by 2023 the same pathway was expected to take only 10 months. This means that they cannot cause disease and they generally do not need to be frozen for storage.

Vaccine 147

Vaccine Production Virus DNA 147

Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration. Credit: Neumann EN, Bertozzi TM, et al.

Disease 142

Disease Therapies Engineering Clinical Trials 142

Alta Sciences

MARCH 1, 2024

Norbert Makori and Pierre Jolicoeur: The Benefits of Combining Preclinical and Bioanalytical for Your Gene Therapy Studies pmjackson Fri, 03/01/2024 - 22:20 Recent advances in gene therapy have allowed for diseases to be approached differently. Q&A With Dr. We have a supply of NHPs to ensure prompt study start.

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

Broad Institute

JANUARY 8, 2024

Williams January 8, 2024 Credit: Susanna Hamilton, Broad Communications Researchers have developed virus-like particles that can deliver gene-editing cargo to cells, including those in the mouse brain. Prime editing, described in 2019 by Liu’s group, can make longer and more diverse types of DNA changes than other types of editing.

Engineering 144

Engineering Research Virus DNA 144

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Doctors in training are told that when they hear hoofbeats, they should think horses, not zebras; rare diseases are the exception, not the rule. After copying the DNA to form a big pool, each piece is sequenced.

DNA 90

DNA Hospitals Laboratories Virus 90

Drug Discovery World

APRIL 30, 2024

Whilst research into mRNA has been ongoing for decade, interest has sparked in recent years and research has begun to expand into areas of vaccinology, infectious diseases and other indications. If the body fails to make the right protein, diseases such as cancer, type II diabetes, neurological conditions, and metabolic diseases can occur.

Therapies 130

Therapies RNA Vaccine Small Molecule 130

Codon

JUNE 11, 2024

Biologists use nanopores for everything from diagnosing diseases and monitoring changes within rainforest ecosystems to discovering proteins from microbes frozen in Icelandic glaciers. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast. An Oxford Nanopore device.

DNA 77

DNA Engineering RNA Small Molecule 77

Drug Discovery World

MAY 23, 2024

This approach is particularly effective against diseases, such as cancer, in which attacking the disease from multiple therapeutic angles can prevent resistance development. Currently, surgical removal is the standard of care for women affected by this disease. CIN is a common precursor to cervical cancer.

RNA 147

RNA Therapies Engineering Disease 147

KIF1A

FEBRUARY 4, 2024

Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. But similar looking diseases won’t necessarily respond to the same treatments, which is why it’s so important to find accurate diagnoses.

RNA 52

RNA DNA Disease Trials 52

Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

Therapies 121

Therapies Virus DNA Clinical Trials 121

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals. Online March 22, 2024.

Engineering 140

Engineering Protein Production RNA Vaccine 140

Codon

FEBRUARY 27, 2024

Patient YY’s neighbors quickly started to become infected, passing on the virus in turn. While the consensus that emerged among experts was that the virus spread primarily via airborne transmission , it also made use of another route: fomite transmission. Puzzled, epidemiologists sought to understand the source of the outbreak.

Virus 73

Virus Hospitals Production Regulations 73

Codon

JULY 21, 2024

Of course, AA and P-line rats are not the only research animals bred for the study of disease. By doing so, researchers study pain, genetic disorders, the effect of drugs, and disease pathways in mammals that, while genetically similar to us, are not human beings. They are bred, incised, injected, and deprived.

Research 119

Research Engineering Science Disease 119

Drug Discovery World

NOVEMBER 9, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Klaus Wagenbauer, PhD, Founder & CEO, Plectonic, on: ‘Programmable DNA-origami-based T cell engagers: PTE’.

Engineering 130

Engineering Therapies Protein Production Science 130

Codon

MARCH 7, 2024

With a flourish of his gloved hand and the aplomb of an evangelical pastor, Wilde continues: “As you are no doubt aware, the Vector Zoo commemorates humanity’s valiant efforts to eradicate zoonotic and vector-borne diseases. Humanity's long battle against malaria has shaped the human genome more than any other disease.

Vaccine 52

Vaccine Disease Doctors DNA 52

Broad Institute

JUNE 10, 2024

The advance, from the lab of Broad core institute member David Liu , could one day help researchers develop a single gene therapy for diseases such as cystic fibrosis that are caused by one of hundreds or thousands of different mutations in a gene.

Engineering 144

Engineering DNA Therapies Disease 144