Drug Discovery World

APRIL 17, 2024

DDW’s Diana Spencer speaks to Josh Mandel-Brehm , CEO of Massachusetts-based biotech CAMP4, to understand the role regulatory RNAs play in gene expression and how the founders overcame the challenge of launching a business based on brand new science. DS: You describe your therapeutics as RNA Amplifiers. How do they work?

Science 147

Science RNA Disease Protein Expression 147

Broad Institute

JULY 19, 2024

By Boston Children's Hospital July 19, 2024 Credit: Scott-Hewitt N, et al. By Boston Children's Hospital July 19, 2024 Credit: Scott-Hewitt N, et al. A new study reveals that C1q can also enter neurons, where it influences protein production, and can accumulate within neurons over time. DOI: 10.1016/j.cell.2024.05.058.

Protein Production 111

Protein Production Hospitals RNA Production 111

Drug Discovery World

APRIL 30, 2024

Messenger RNA (mRNA) has come into focus within the drug discovery and development as an exciting tool to deliver genetic information. Whilst research into mRNA has been ongoing for decade, interest has sparked in recent years and research has begun to expand into areas of vaccinology, infectious diseases and other indications.

Therapies 130

Therapies RNA Vaccine Small Molecule 130

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

Engineering 140

Engineering Protein Production RNA Vaccine 140

Drug Discovery World

NOVEMBER 13, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. These topics include: High-throughput (HTP) protein production and AI and automation in bioprocess development.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Codon

MARCH 24, 2024

Credit: Universität Würzburg Archives His key insight hinged upon the fact that living cells are essentially bags of liquid filled with enzymes, or proteins that speed up chemical reactions. Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on.

Engineering 85

Engineering Vaccine Production RNA 85