Broad Institute

JANUARY 8, 2024

Williams January 8, 2024 Credit: Susanna Hamilton, Broad Communications Researchers have developed virus-like particles that can deliver gene-editing cargo to cells, including those in the mouse brain. Prime editing, described in 2019 by Liu’s group, can make longer and more diverse types of DNA changes than other types of editing.

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Broad Institute

MARCH 26, 2024

Researchers have identified a genetic variant in people with Indigenous American ancestry that may account for the increased risk of ALL in Hispanic/Latino children, who have more of this ancestry than other populations. The researchers also found that the mutation is much less common in white non-Hispanic/Latino children.

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DNA Research Disease Treatment 59

KIF1A

JANUARY 27, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. This study also highlights the diversity of HSP types: across 18 patients, researchers identified 15 different spastic paraplegia subtypes.

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Therapies Small Molecule DNA Treatment 111

Broad Institute

JUNE 28, 2023

Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. The chemical reactions that he discovered in the early 1980s to accurately and quickly assemble nucleotides into strands of DNA provided an essential element in the development of modern molecular medicine.

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Drug Target Review

JULY 9, 2024

2 DNA repair mechanism disruption is a significant cause of increased cancer risk, with around 20 percent of bowel cancers known as mismatch repair deficient (MMRd) cancers, which have mutations in DNA repair genes. She continued: “The really interesting finding from our research is what happens afterwards.

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Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

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KIF1A

FEBRUARY 18, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias What causes KAND?

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Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Nominations for the 2024 Merkin Prize opened on September 6, 2023 and close on December 6, 2023 at 11:59 pm ET.

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KIF1A

FEBRUARY 4, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. In this week’s article, researchers in Japan performed whole genome sequencing on 315 patients who were enrolled in the HAM patient registry.

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RNA DNA Disease Trials 52

Broad Institute

OCTOBER 3, 2024

Largest-ever genetic study of epilepsy finds possible therapeutic targets By Ari Navetta October 3, 2024 Breadcrumb Home Largest-ever genetic study of epilepsy finds possible therapeutic targets Scientists have uncovered new genetic links to different types of epilepsy, which could lead to more tailored treatments.

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DNA Doctors Treatment Disease 133

Broad Institute

OCTOBER 23, 2024

By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.

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Broad Institute

MARCH 8, 2024

By Claire Hendershot March 8, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health via U.S. One of the reasons that I've traveled so much there over the years is that this is a close research partnership. Online January 25, 2024. Nature Communications. DOI: 10.1038/s41467-024-44800-7.

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Research Disease Medical Schools RNA 111

Broad Institute

AUGUST 8, 2024

Kan Xiong By Rose Circeo August 8, 2024 Martin-Alonso C, Tabrizi S, Xiong K, et al. Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies. Comparison of whole-genome and immunoglobulin-based circulating tumor DNA assays in diffuse large B-cell lymphoma. Published 2024 Apr 1.

DNA 52

DNA Science Research 52

Broad Institute

JUNE 10, 2024

The advance, from the lab of Broad core institute member David Liu , could one day help researchers develop a single gene therapy for diseases such as cystic fibrosis that are caused by one of hundreds or thousands of different mutations in a gene.

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DNA Engineering Therapies Disease 144

Drugs.com

JULY 19, 2024

THURSDAY, July 19, 2024 -- As good as many genetic tests might be, a deeper look at the DNA of over 44,000 people identified many who carried genes that hike their risks for cancer, researchers said."This This study is a wake-up call, showing us that.

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DNA Research 59

Broad Institute

SEPTEMBER 11, 2024

Azeet Narayan By Maria Nemchuk September 11, 2024 Goldberg SB, Narayan A, Kole AJ, et al. Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA. Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing. Clin Cancer Res. Nat Methods.

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SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

“In this study, we report an approach for spatially resolving genomic patterns of DNA methylation disorder […]” Credit: 2024 Bertucci-Richter et al. “In

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PLOS: DNA Science

MARCH 28, 2024

Research also took place in two facilities in Italy, with sponsorship from Italfarmaco S.p.A. Results from the study that led to the FDA approval appeared in The Lancet Neurology in April 2024 with commentary. million DNA bases. Researchers have been working on developing gene therapy for DMD for decades.

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Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. Previous research has shown that as little as 21 percent elimination of the protein can improve symptoms. Credit: Neumann EN, Bertozzi TM, et al.

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Codon

NOVEMBER 8, 2024

Even today, researchers offer overlapping, but distinct, criteria. Mitochondria also pump out protons through their inner membrane to maintain an out-of-equilibrium thermodynamic balance, using the resulting gradient to produce the ATP molecules that fuel cellular functions, from DNA replication to protein synthesis. DOI: [link]

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Alta Sciences

APRIL 17, 2024

Five Promising Treatment Areas in Early-Phase Drug Development in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drug development is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues.

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Broad Institute

FEBRUARY 19, 2024

By Claire Hendershot February 19, 2024 Source: iStockPhoto An international collaboration of research teams has conducted the largest and most ancestrally diverse genome-wide association study for type 2 diabetes (T2D). By analyzing the DNA of 2.5 Online February 19, 2024. Nature Metabolism.

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Fierce BioTech

MAY 30, 2024

dfarris Thu, 05/30/2024 - 11:14 Download this resource to accelerate your oncology clinical trials, optimize patient enrollment, and monitor minimal residual disease and molecular response effectively.

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Clinical Trials DNA Trials Therapies 52

Drug Target Review

JANUARY 26, 2024

Researchers from Columbia University and the US Department of Energy (DOE)’s Brookhaven National Laboratory have elucidated a method to produce large quantities of the receptor that the SARS-CoV-2 spike protein uses to bind to the surface of human cells. 2020 March 30 [2024 January 22]; 581:215-220. Available from: [link]

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Production DNA Virus Protein Expression 114

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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Alta Sciences

APRIL 16, 2024

Inside The Altascientist: The Benefits of PCR for Your Gene Therapy Programs pmjackson Tue, 04/16/2024 - 19:04 The gene therapy landscape continues to accelerate in preclinical and clinical research, with programs constantly in development for targeted, personalized medicines. But how are PCR analysis techniques applied?

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Broad Institute

AUGUST 8, 2024

Shervin Tabrizi By Rose Circeo August 8, 2024 Shervin Tabrizi, M.D. His work focuses on developing novel technologies to improve the performance of liquid biopsies for cancer detection, using approaches in protein engineering to create agents that can improve the recovery of cell-free DNA from the body. Tabrizi earned his M.D.

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Broad Institute

JULY 10, 2024

Now, researchers at the Broad Institute of MIT and Harvard and the University of Iowa have developed a gene-editing approach that efficiently corrects the most common mutation that causes cystic fibrosis, found in 85 percent of patients. Online July 10, 2024. The new approach also generated 3.5 Nature Biomedical Engineering.

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Engineering Packaging DNA Treatment 145

Broad Institute

JUNE 14, 2024

Some CRISPR screens may be missing cancer drug targets By Allessandra DiCorato June 14, 2024 Breadcrumb Home Some CRISPR screens may be missing cancer drug targets Current CRISPR guides don’t work equally well in cells from people of all ancestries, which could lead to false negative results.

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Drugs RNA DNA Research 145

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. By Broad Communications May 14, 2024 F. Studier will be honored in a prize ceremony held on September 17, 2024. Photo courtesy of BNL.

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RNA Production Molecular Biology Laboratories 84

Broad Institute

AUGUST 29, 2024

Jack By amatosni@broadinstitute.org August 29, 2024 Jack Jack Boston Latin School Boston, MA Mentors: Allison Uebele and Laura Drepanos Genetic Perturbation Platform Jack applied to the BSSP program because he felt “It would be amazing to be able to see the real-life science behind what I have learned already and what I haven’t yet learned.”

DNA 52

DNA Science Research 52

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

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DNA Engineering RNA Small Molecule 71

Broad Institute

FEBRUARY 27, 2024

Broad-MIT Seminars in Chemical Biology By Rose Circeo February 27, 2024 Breadcrumb Home Research Broad-MIT Seminars in Chemical Biology MIT Chemistry and the Broad Institute host monthly seminars in chemical biology with the intent to hear from the thought-leaders and bring together chemical biologists from both academia and industry in the Boston/Cambridge (..)

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RNA DNA Regulations Disease 52

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. However, E.

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DNA RNA Laboratories Engineering 69

Drug Target Review

MAY 24, 2024

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). ChatGPT [Internet] 2024 [updated 2024 May 12; cited 2024 May] Available from: [link] 2 Howe NP, Thompson B. Nature [Internet] 2024 [updated 2024 May 8; cited 2024 May]. References 1 Wikipedia. Alphafold 3.0:

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RNA DNA Bioinformatics Science 59

Broad Institute

APRIL 2, 2024

Scientists link certain gut bacteria to lower heart disease risk By Allessandra DiCorato April 2, 2024 Breadcrumb Home Scientists link certain gut bacteria to lower heart disease risk Study finds several species of cholesterol-metabolizing bacteria in people with lower cholesterol levels.

Disease 145

Disease Medical Schools Hospitals DNA 145

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals. and Virginia W.

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