Broad Institute

JUNE 28, 2023

Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. The chemical reactions that he discovered in the early 1980s to accurately and quickly assemble nucleotides into strands of DNA provided an essential element in the development of modern molecular medicine.

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Drug Target Review

JULY 9, 2024

2 DNA repair mechanism disruption is a significant cause of increased cancer risk, with around 20 percent of bowel cancers known as mismatch repair deficient (MMRd) cancers, which have mutations in DNA repair genes. She continued: “The really interesting finding from our research is what happens afterwards.

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Regulations DNA Treatment Research 105

Drug Discovery World

MARCH 4, 2024

Clinical Microbiomics has acquired DNASense, a Danish microbiome clinical research organisation (CRO) specialised in long-read DNA and RNA sequencing technologies and bioinformatics. The acquisition adds long-read DNA and RNA sequencing technologies to Clinical Microbiomics’ multi-omics technologies for the microbiome field.

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KIF1A

FEBRUARY 18, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias What causes KAND?

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Therapies DNA Clinical Trials Trials 52

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Nominations for the 2024 Merkin Prize opened on September 6, 2023 and close on December 6, 2023 at 11:59 pm ET.

DNA 52

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Broad Institute

OCTOBER 3, 2024

Largest-ever genetic study of epilepsy finds possible therapeutic targets By Ari Navetta October 3, 2024 Breadcrumb Home Largest-ever genetic study of epilepsy finds possible therapeutic targets Scientists have uncovered new genetic links to different types of epilepsy, which could lead to more tailored treatments.

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Drug Discovery World

AUGUST 21, 2024

Following initial viral vector transduction, treated samples, typically whole blood and/or enriched cell populations, are collected and the genomic DNA is isolated. The enriched DNA is then sequenced. With this approach, high molecular weight DNA must be extracted from the treated samples, to ensure the best results.

Therapies 147

Therapies Bioinformatics DNA FDA 147

Broad Institute

MARCH 8, 2024

By Claire Hendershot March 8, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health via U.S. One of the reasons that I've traveled so much there over the years is that this is a close research partnership. Online January 25, 2024. Nature Communications. DOI: 10.1038/s41467-024-44800-7.

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Research Disease Medical Schools RNA 111

Broad Institute

SEPTEMBER 11, 2024

Azeet Narayan By Maria Nemchuk September 11, 2024 Goldberg SB, Narayan A, Kole AJ, et al. Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA. Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing. Clin Cancer Res. Nat Methods.

DNA 52

DNA RNA Research Production 52

Drugs.com

JULY 19, 2024

THURSDAY, July 19, 2024 -- As good as many genetic tests might be, a deeper look at the DNA of over 44,000 people identified many who carried genes that hike their risks for cancer, researchers said."This This study is a wake-up call, showing us that.

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DNA Research 59

Drug Discovery World

AUGUST 22, 2024

Dr Rosenzweig-Lipson says: “We are at the forefront of drug development in an area of research called cellular rejuvenation, which is an approach that has the potential to address many diseases of ageing by restoring aged and injured cells to a more youthful and resilient state.

Therapies 147

Therapies DNA Disease RNA 147

Drug Discovery World

JULY 23, 2024

3D genome folding DNA within the cell nucleus is more than the simple linear thread of primary sequence; it is tightly packed and folded non-randomly in a cell-type specific manner. To realise the promise of personalised medicine, we must ensure all research data can be effectively integrated to change the patient journey.

DNA 130

DNA Disease Regulations Molecular Biology 130

Drug Discovery World

JUNE 7, 2023

Hosted by DDW and sponsored by DNA Script, join us for this free-to-attend roundtable to learn about the biggest opportunities for the future of drug discovery and development. Roundtable panellists include Commercial Research Scientist, Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta.

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DNA Clinical Trials Drugs Vaccine 130

Drug Discovery World

JUNE 27, 2023

Hosted by DDW and supported by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Roundtable panelists include Commercial Research Scientist Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta. What can we expect from the cell & gene therapy market?

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DNA Drugs Clinical Trials Vaccine 130

Drug Discovery World

JUNE 22, 2023

Hosted by DDW and supported by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Roundtable panelists include Commercial Research Scientist Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta. What can we expect from the cell & gene therapy market?

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DNA Clinical Trials Drugs Vaccine 130

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

“In this study, we report an approach for spatially resolving genomic patterns of DNA methylation disorder […]” Credit: 2024 Bertucci-Richter et al. “In

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DNA Research 59

Drug Discovery World

JUNE 15, 2023

Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Roundtable panelists include Commercial Research Scientist, Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta. What can we expect from the cell & gene therapy market?

DNA 130

DNA Drugs Clinical Trials Vaccine 130

Drug Discovery World

JUNE 8, 2023

Hosted by DDW and sponsored by DNA Script, ‘Drug discovery and development trends – what will have most impact?’ Roundtable panelists include Commercial Research Scientist Dr Mark Treherne, CEO of Elevation Oncology, Joe Ferra, and CEO of BioXcel Therapeutics, Vimal Mehta. What can we expect from the cell & gene therapy market?

Drugs 130

Drugs DNA Clinical Trials Vaccine 130

Drug Discovery World

SEPTEMBER 25, 2024

Figure 1: Major deals involving ADCs- 2024 Figure 2: Examples of FDA-approved ADCs – 2024 These include Johnson & Johnson’s $2 billion purchase of ADC specialist Ambrx in January, Genmab’s $1.8 This requires extensive preclinical research and validation.”

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Drug Discovery World

OCTOBER 2, 2023

The goal is to generate DNA-encoded library (DEL) screening data for large numbers of under-addressed proteins in the human proteome – ultimately allowing drug discovery and machine learning (ML) experts from around the world to use the data to unlock disease targets of the future.

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DNA Disease Science Research 130

Drug Discovery World

OCTOBER 20, 2023

The acquisition of Olink underscores the profound impact that proteomics is having as our customers continue to advance life science research and precision medicine,” said Marc Casper, Chairman, President and Chief Executive Officer of Thermo Fisher.

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DNA Clinical Trials Engineering Virus 130

Drug Discovery World

SEPTEMBER 2, 2024

DDW’s Megan Thomas discusses the future of the cell and gene therapy (CGT) sector with industry experts, who predict what to expect in 2024 and beyond. Vincent Smith, Chief Technology Officer, Broken String Biosciences, anticipates significant developments in the CGT space in 2024 and beyond.

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Fierce BioTech

MAY 30, 2024

dfarris Thu, 05/30/2024 - 11:14 Download this resource to accelerate your oncology clinical trials, optimize patient enrollment, and monitor minimal residual disease and molecular response effectively.

Clinical Trials 52

Clinical Trials DNA Trials Therapies 52

Drug Discovery World

FEBRUARY 8, 2024

AAV is optimal for gene therapy due to its efficiency and safety in humans; however, AAV processes can present obstacles for researchers. These include automated solutions, proprietary genomics protocols, specialists to advise on global cGMP repository and logistics, plus experts to guide researchers through advanced therapy development.

Therapies 147

Therapies Bioinformatics Packaging Molecular Biology 147

Broad Institute

AUGUST 8, 2024

Shervin Tabrizi By Rose Circeo August 8, 2024 Shervin Tabrizi, M.D. His work focuses on developing novel technologies to improve the performance of liquid biopsies for cancer detection, using approaches in protein engineering to create agents that can improve the recovery of cell-free DNA from the body. Tabrizi earned his M.D.

Medical Schools 52

Medical Schools Hospitals DNA Engineering 52

PLOS: DNA Science

MARCH 28, 2024

Research also took place in two facilities in Italy, with sponsorship from Italfarmaco S.p.A. Results from the study that led to the FDA approval appeared in The Lancet Neurology in April 2024 with commentary. million DNA bases. Researchers have been working on developing gene therapy for DMD for decades.

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FDA Approval Treatment FDA DNA 87

Drug Target Review

JANUARY 26, 2024

Researchers from Columbia University and the US Department of Energy (DOE)’s Brookhaven National Laboratory have elucidated a method to produce large quantities of the receptor that the SARS-CoV-2 spike protein uses to bind to the surface of human cells. 2020 March 30 [2024 January 22]; 581:215-220. Available from: [link]

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Production DNA Virus Protein Expression 114

Broad Institute

JULY 10, 2024

Now, researchers at the Broad Institute of MIT and Harvard and the University of Iowa have developed a gene-editing approach that efficiently corrects the most common mutation that causes cystic fibrosis, found in 85 percent of patients. Online July 10, 2024. The new approach also generated 3.5 Nature Biomedical Engineering.

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Broad Institute

AUGUST 29, 2024

Jack By amatosni@broadinstitute.org August 29, 2024 Jack Jack Boston Latin School Boston, MA Mentors: Allison Uebele and Laura Drepanos Genetic Perturbation Platform Jack applied to the BSSP program because he felt “It would be amazing to be able to see the real-life science behind what I have learned already and what I haven’t yet learned.”

DNA 52

DNA Science Research 52

Alta Sciences

APRIL 16, 2024

Inside The Altascientist: The Benefits of PCR for Your Gene Therapy Programs pmjackson Tue, 04/16/2024 - 19:04 The gene therapy landscape continues to accelerate in preclinical and clinical research, with programs constantly in development for targeted, personalized medicines. But how are PCR analysis techniques applied?

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Therapies DNA RNA Laboratories 52

Broad Institute

JUNE 14, 2024

Some CRISPR screens may be missing cancer drug targets By Allessandra DiCorato June 14, 2024 Breadcrumb Home Some CRISPR screens may be missing cancer drug targets Current CRISPR guides don’t work equally well in cells from people of all ancestries, which could lead to false negative results.

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Drug Target Review

MAY 24, 2024

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). ChatGPT [Internet] 2024 [updated 2024 May 12; cited 2024 May] Available from: [link] 2 Howe NP, Thompson B. Nature [Internet] 2024 [updated 2024 May 8; cited 2024 May]. References 1 Wikipedia. Alphafold 3.0:

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RNA DNA Bioinformatics Science 59

Broad Institute

FEBRUARY 27, 2024

Broad-MIT Seminars in Chemical Biology By Rose Circeo February 27, 2024 Breadcrumb Home Research Broad-MIT Seminars in Chemical Biology MIT Chemistry and the Broad Institute host monthly seminars in chemical biology with the intent to hear from the thought-leaders and bring together chemical biologists from both academia and industry in the Boston/Cambridge (..)

RNA 52

RNA DNA Regulations Disease 52

Broad Institute

APRIL 2, 2024

Scientists link certain gut bacteria to lower heart disease risk By Allessandra DiCorato April 2, 2024 Breadcrumb Home Scientists link certain gut bacteria to lower heart disease risk Study finds several species of cholesterol-metabolizing bacteria in people with lower cholesterol levels.

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Disease Medical Schools Hospitals DNA 145

Drug Discovery World

FEBRUARY 7, 2024

Professor Blackburn began by sharing an overview of his current research, including the work he does with Sengenics. He’s the CSO of Sengenics, but also has an academic appointment at the University of Cape Town where he holds a research chair in proteomics and chemical biology. Access the full podcast episode.

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FDA Approval Disease DNA FDA 147

Drug Discovery World

AUGUST 29, 2024

HT surface plasmon resonance In the field of antibody research, Eli Lilly and AbCellera have credited Carterra’s LSA biosensor which uses High-Throughput Surface Plasmon Resonance (HT-SPR) technology for enabling a clinical candidate in less than 90 days. “SPR

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Small Molecule Drugs Protein Expression Assay Development 147

Drug Discovery World

FEBRUARY 6, 2024

Technologies like artificial intelligence (AI), machine learning (ML) and robotics/automation are enabling researchers to process enormous data sets and conduct preclinical investigations in record time, speeding up the process and offering greater accuracy. Universities are also using these digital technologies to advance their research.

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