KIF1A

JANUARY 13, 2024

Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. As one cell turns into two, its DNA must be replicated and then pulled apart, so that when the cell divides each has all the DNA it needs to function.

DNA 105

DNA Regulations Drug Development Disease 105

Broad Institute

JUNE 28, 2023

Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. The chemical reactions that he discovered in the early 1980s to accurately and quickly assemble nucleotides into strands of DNA provided an essential element in the development of modern molecular medicine.

DNA 98

DNA RNA Science Therapies 98

KIF1A

JANUARY 27, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. This study also highlights the diversity of HSP types: across 18 patients, researchers identified 15 different spastic paraplegia subtypes.

Therapies 111

Therapies Small Molecule DNA Treatment 111

Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

DNA 133

DNA Engineering Science Disease 133

Drug Target Review

JULY 9, 2024

2 DNA repair mechanism disruption is a significant cause of increased cancer risk, with around 20 percent of bowel cancers known as mismatch repair deficient (MMRd) cancers, which have mutations in DNA repair genes. She continued: “The really interesting finding from our research is what happens afterwards.

Regulations 106

Regulations DNA Treatment Research 106

Broad Institute

JUNE 10, 2024

The advance, from the lab of Broad core institute member David Liu , could one day help researchers develop a single gene therapy for diseases such as cystic fibrosis that are caused by one of hundreds or thousands of different mutations in a gene.

DNA 144

DNA Engineering Therapies Disease 144

Broad Institute

DECEMBER 11, 2024

#WhyIScience Q&A: A computational biologists world travels have shaped her approach to research By Corie Lok December 11, 2024 Breadcrumb Home #WhyIScience Q&A: A computational biologists world travels have shaped her approach to research Wolu Chukwu talks about how she brings a community-first focus to her work in cancer genetics.

Research 105

Research DNA Clinical Research Science 105

Broad Institute

OCTOBER 3, 2024

Largest-ever genetic study of epilepsy finds possible therapeutic targets By Ari Navetta October 3, 2024 Breadcrumb Home Largest-ever genetic study of epilepsy finds possible therapeutic targets Scientists have uncovered new genetic links to different types of epilepsy, which could lead to more tailored treatments.

DNA 133

DNA Doctors Treatment Disease 133

Broad Institute

MARCH 26, 2024

Researchers have identified a genetic variant in people with Indigenous American ancestry that may account for the increased risk of ALL in Hispanic/Latino children, who have more of this ancestry than other populations. The researchers also found that the mutation is much less common in white non-Hispanic/Latino children.

DNA 59

DNA Research Disease Treatment 59

Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. Previous research has shown that as little as 21 percent elimination of the protein can improve symptoms. Credit: Neumann EN, Bertozzi TM, et al.

Disease 142

Disease Therapies Clinical Trials Engineering 142

Broad Institute

MARCH 8, 2024

By Claire Hendershot March 8, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health via U.S. One of the reasons that I've traveled so much there over the years is that this is a close research partnership. Online January 25, 2024. Nature Communications. DOI: 10.1038/s41467-024-44800-7.

Research 111

Research Disease Medical Schools RNA 111

Broad Institute

OCTOBER 23, 2024

By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.

DNA 128

DNA RNA Disease Hospitals 128

Broad Institute

JUNE 14, 2024

Some CRISPR screens may be missing cancer drug targets By Allessandra DiCorato June 14, 2024 Breadcrumb Home Some CRISPR screens may be missing cancer drug targets Current CRISPR guides don’t work equally well in cells from people of all ancestries, which could lead to false negative results.

Drugs 145

Drugs RNA DNA Research 145

Broad Institute

FEBRUARY 19, 2024

By Claire Hendershot February 19, 2024 Source: iStockPhoto An international collaboration of research teams has conducted the largest and most ancestrally diverse genome-wide association study for type 2 diabetes (T2D). By analyzing the DNA of 2.5 Online February 19, 2024. Nature Metabolism.

DNA 126

DNA Disease Research International 126

Broad Institute

JULY 10, 2024

Now, researchers at the Broad Institute of MIT and Harvard and the University of Iowa have developed a gene-editing approach that efficiently corrects the most common mutation that causes cystic fibrosis, found in 85 percent of patients. Online July 10, 2024. The new approach also generated 3.5 Nature Biomedical Engineering.

Engineering 145

Engineering Packaging DNA Treatment 145

Broad Institute

APRIL 2, 2024

Scientists link certain gut bacteria to lower heart disease risk By Allessandra DiCorato April 2, 2024 Breadcrumb Home Scientists link certain gut bacteria to lower heart disease risk Study finds several species of cholesterol-metabolizing bacteria in people with lower cholesterol levels.

Disease 145

Disease Medical Schools Hospitals DNA 145

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals. and Virginia W.

Engineering 140

Engineering Protein Production RNA Vaccine 140

PLOS: DNA Science

MARCH 28, 2024

Research also took place in two facilities in Italy, with sponsorship from Italfarmaco S.p.A. Results from the study that led to the FDA approval appeared in The Lancet Neurology in April 2024 with commentary. million DNA bases. Researchers have been working on developing gene therapy for DMD for decades.

FDA Approval 97

FDA Approval Treatment FDA DNA 97

Drug Target Review

JANUARY 26, 2024

Researchers from Columbia University and the US Department of Energy (DOE)’s Brookhaven National Laboratory have elucidated a method to produce large quantities of the receptor that the SARS-CoV-2 spike protein uses to bind to the surface of human cells. 2020 March 30 [2024 January 22]; 581:215-220. Available from: [link]

Production 115

Production DNA Virus Protein Expression 115

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Nominations for the 2024 Merkin Prize opened on September 6, 2023 and close on December 6, 2023 at 11:59 pm ET.

DNA 52

DNA RNA Science Protein Expression 52

Codon

NOVEMBER 3, 2024

Even after microbiologists discovered the bacterium that causes the illness in 1882, it wasn’t until the 1920s that researchers were able to develop a vaccine for TB. Chilean research participants aged 15 to 35 who received the vaccine during a case-control study , for example, only showed a 10 percent reduced risk of pulmonary TB.

Vaccine 92

Vaccine Trials Therapies Clinical Trials 92

Broad Institute

FEBRUARY 16, 2024

Study finds youth-onset diabetes is a genetically distinct form of the disorder By Claire Hendershot February 16, 2024 Breadcrumb Home Study finds youth-onset diabetes is a genetically distinct form of the disorder Researchers suggest diabetes exists in multiple forms on a spectrum of varying genetic factors and symptoms.

Medical Schools 133

Medical Schools Hospitals Disease DNA 133

KIF1A

FEBRUARY 18, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Overarching pathomechanisms in inherited peripheral neuropathies, spastic paraplegias, and cerebellar ataxias What causes KAND?

Therapies 52

Therapies Clinical Trials DNA Trials 52

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 93

DNA Laboratories Hospitals Virus 93

KIF1A

FEBRUARY 4, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. In this week’s article, researchers in Japan performed whole genome sequencing on 315 patients who were enrolled in the HAM patient registry.

RNA 52

RNA DNA Disease Trials 52

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. By Broad Communications May 14, 2024 F. Studier will be honored in a prize ceremony held on September 17, 2024. Photo courtesy of BNL.

RNA 84

RNA Production Molecular Biology Laboratories 84

SCIENMAG: Medicine & Health

FEBRUARY 6, 2024

“In this study, we report an approach for spatially resolving genomic patterns of DNA methylation disorder […]” Credit: 2024 Bertucci-Richter et al. “In

DNA 59

DNA Research 59

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA 79

DNA Engineering RNA Small Molecule 79

Broad Institute

AUGUST 8, 2024

Kan Xiong By Rose Circeo August 8, 2024 Martin-Alonso C, Tabrizi S, Xiong K, et al. Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies. Comparison of whole-genome and immunoglobulin-based circulating tumor DNA assays in diffuse large B-cell lymphoma. Published 2024 Apr 1.

DNA 52

DNA Science Research 52

Drug Target Review

FEBRUARY 16, 2024

For the first time, the researchers demonstrated that measuring the overall burden of IGR could potentially predict immune cell infiltration and immunotherapy response in certain cancers. Two distinct classes of cancers The researchers investigated the relationship between IGR and TMB in different tumour types. Available at: [link]

Clinical Trials 106

Clinical Trials DNA Treatment Trials 106

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. However, E.

DNA 75

DNA RNA Laboratories Research 75

Broad Institute

MARCH 25, 2024

By Leah Eisenstadt March 25, 2024 Credit: Allison Colorado, Broad Communications Alex Navarro, Senior Program Coordinator for the Broad Biomedical Post-baccalaureate Scholars Program Alex Navarro didn’t always aspire to a career in science. and they suggested I might enjoy the curiosity involved in research. in cell biology.

Science 111

Science Cell Biology Research DNA 111

Codon

FEBRUARY 13, 2024

Goodsell, RCSB Protein Data Bank and Scripps Research. 1 Yet even after more than two decades of research, media hype, and dozens of clinical trials and biotech start-ups that have come and gone, phage therapy has not scaled. Still, researchers are trying. Read it on our website here. Illustration by David S.

Therapies 124

Therapies Virus DNA Clinical Trials 124

Codon

JUNE 30, 2024

Modern biotechnology began in 1972 when biochemists at Stanford University spliced together DNA from two different organisms. The race to exploit recombinant DNA technology was on. General Electric Research Laboratory in Schenectady, New York. Stanley Cohen’s laboratory bench from 1973. Join Asimov Press.

DNA 95

DNA Engineering Laboratories Production 95

Alta Sciences

APRIL 17, 2024

Five Promising Treatment Areas in Early-Phase Drug Development in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drug development is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues.

Drug Development 52

Drug Development Treatment FDA Approval Drugs 52

Broad Institute

FEBRUARY 29, 2024

By Leah Eisenstadt February 29, 2024 Credit: Courtesy of (clockwise, from top left) National Park Service; Rainer Zenz, Creative Commons license; Len Charnoff/Flickr, public domain; Riki7, public domain; National Park Service; Rufus46, Creative Commons.

Hospitals 116

Hospitals Medical Schools International Research 116

BMG Labtech

DECEMBER 20, 2024

Absorbance measurements, often referred to as light absorbance, are so versatile and widespread that they are one of the first techniques many life science researchers encounter in a practical setting. Nucleic acid quantification Researchers are often faced with the need to quantify nucleic acids in samples.

DNA 52

DNA Science Laboratories RNA 52