Remove 2024 Remove Drug Development Remove Small Molecule
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Redefining Acceleration of the Drug Development Journey

PPD

It is hard to ignore some of the most pressing, long-term trends driving the push to accelerate innovation and progress in drug development. According to the United Nation’s 2024 World Population Prospects data, the global population of those 65 years old and over will grow from 0.8 billion in 2023 to 1.2 billion in 2035.

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Location-agnostic site-specific protein bioconjugation via Baylis Hillman adducts

Covalent Modifiers

Nat Commun 15 , 859 (2024). link] Proteins labelled site-specifically with small molecules are valuable assets for chemical biology and drug development. In addition to protein bioconjugation, the bis-heterocyclic scaffold we report herein will find applications in synthetic and medicinal chemistry.

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Sentiment & Themes Emerging From JPM 2024

LifeSciVC

Small molecule GLP1s? Whether trial design, execution, or otherwise, drug development even where there is precedent is a challenging road and should not be taken for granted. Whether it’s small molecules to target the incretins (GLP1R ± GIPR), targeting well-validated signaling nodes in I&I (e.g.,

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Professor Bruce Freeman: Keynote Speaker of the 26th International Conference of the Redox Medicine Society

SCIENMAG: Medicine & Health

Credit: Redox Medicine […]

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Five Promising Treatment Areas in Early-Phase Drug Development in 2024

Alta Sciences

Five Promising Treatment Areas in Early-Phase Drug Development in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drug development is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues.

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Looking beyond traditional oncogenic pathways to break cancer resistance

Drug Target Review

However, this will not be straightforward, given that non-oncogene resistance is driven by complex transcriptional networks, and the key drivers that determine how these mechanisms could be targets for drug development remain elusive. This orally available small molecule binds to the bromodomain of CBP/p300 in a highly specific manner.

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Liquid biopsy helps advance oncology drug development

Drug Target Review

Why is detecting cancers via liquid biopsy before they become visible on imaging important for drug development, not just diagnostics? We believe liquid biopsy is very helpful for oncology drug development because the reduction and clearance of circulating DNA occurs quickly before radiographic imaging is available.