Broad Institute

SEPTEMBER 26, 2024

Recently published literature has identified three proteins (Lap2β, H3K9me3, and HP1γ) that exhibit decreased expression in aged fibroblasts and a “senescence cocktail” of small molecules that have been observed to reduce the expression of these chromatin proteins in a way that models aged cells.

Small Molecule 52

Small Molecule Protein Expression Disease Science 52

Alta Sciences

APRIL 17, 2024

Five Promising Treatment Areas in Early-Phase Drug Development in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drug development is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues.

Drug Development 52

Drug Development Treatment FDA Approval Drugs 52

Conversations in Drug Development Trends

MAY 30, 2024

According to Citeline , there are 160 ALS studies planned or ongoing in 2024 with various sponsors such as academia, consortia, government, and industry, not including studies in HV populations. However, work is needed before CRISPR-mediated treatments become possible, including a better understanding of the genes involved in ALS.

Treatment 81

Treatment Clinical Trials Small Molecule Therapies 81