Broad Institute

APRIL 4, 2024

A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis By Rose Circeo April 4, 2024 Breadcrumb Home A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease.

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RNA Bioethics Disease Research 52

Drug Discovery World

AUGUST 7, 2024

The grant will fund a collaboration that combines scientific expertise with machine vision tools with an aim to streamline the synthesis, purification and analysis of RNA medicines. Innovate UK is a part of UK Research and Innovation (UKRI) and they are the UK’s national innovation agency.

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RNA Government Therapies Science 147

Covalent Modifiers

FEBRUARY 25, 2024

2024 , DOI: 10.1039/D3CB00230F N6-Methyladenosine (m6A) is the most prevalent mRNA modification and is required for gene regulation in eukaryotes. TD19 irreversibly modifies the residues C100 and C267, preventing ALKBH5 from binding to m6A-containing RNA.

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RNA Cell Based Assays Regulations Research 75

Broad Institute

SEPTEMBER 23, 2024

New approach may yield modified messenger RNAs for treating a wide range of conditions By Ari Navetta September 23, 2024 Breadcrumb Home New approach may yield modified messenger RNAs for treating a wide range of conditions The LEGO framework could help scientists create mRNA therapies that last longer and require smaller doses.

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RNA Vaccine Small Molecule Therapies 132

Drug Discovery World

MARCH 4, 2024

Clinical Microbiomics has acquired DNASense, a Danish microbiome clinical research organisation (CRO) specialised in long-read DNA and RNA sequencing technologies and bioinformatics. The acquisition adds long-read DNA and RNA sequencing technologies to Clinical Microbiomics’ multi-omics technologies for the microbiome field.

Bioinformatics 130

Bioinformatics RNA DNA Clinical Research 130

Drug Discovery World

JANUARY 2, 2024

Cancer Research Horizon’s Innovation Summit 2023 took place on 21 November 2023 at the Royal Society of Medicine, and included talks from researchers translating their research, as well as networking with members of the entrepreneurial ecosystem. As for Infinitopes, the company’s trials will begin in 2024.

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Research Vaccine Science Trials 147

Drugs.com

JANUARY 3, 2024

3, 2024 -- A regularly prescribed class of heart medications might be capable of treating one of the most common forms of muscular dystrophy, a new study in mice suggests.Myotonic dystrophy type 1 (DM1) is caused by abnormal RNA. WEDNESDAY, Jan.

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RNA Research Drugs 97

LifeSciVC

JANUARY 16, 2024

Tirzepatide is also trialing in a Phase 3 obese HFpEF trial, and top-line readout in 2H 2024 will suggest whether the increased weight loss achieved with dual GLP1/GIPR modulation further improves QoL and functional endpoints. ALT) continue to build momentum in the indication. Will incretins “solve” MASH in obese patients?

Small Molecule 139

Small Molecule Trials Therapies Disease 139

Drug Discovery World

APRIL 17, 2024

DDW’s Diana Spencer speaks to Josh Mandel-Brehm , CEO of Massachusetts-based biotech CAMP4, to understand the role regulatory RNAs play in gene expression and how the founders overcame the challenge of launching a business based on brand new science. DS: How easy was it to transfer theoretical research into a viable business?

Science 147

Science RNA Disease Protein Expression 147

Broad Institute

JUNE 18, 2024

Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus.

Virus 144

Virus RNA Medical Schools Laboratories 144

Broad Institute

MARCH 8, 2024

By Claire Hendershot March 8, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health via U.S. One of the reasons that I've traveled so much there over the years is that this is a close research partnership. Online January 25, 2024. Nature Communications. DOI: 10.1038/s41467-024-44800-7.

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Research Disease Medical Schools RNA 111

Drug Discovery World

APRIL 18, 2024

Nutcracker Therapeutics’ prostate cancer mRNA drug candidate NTX-470 successfully engaged CD3 T cells, while retaining low bystander activity and reduced off-tumour binding, according to data presented at the 2024 AACR Annual Meeting.

RNA 130

RNA Engineering Drugs Treatment 130

Drug Discovery World

MAY 17, 2024

‘Proactive’ vaccine protects against unknown future coronaviruses Researchers have developed a new vaccine technology that can provide protection against a broad range of coronaviruses with potential for future disease outbreaks – including ones we don’t know about yet.

Therapies 130

Therapies Vaccine RNA Clinical Trials 130

Drug Discovery World

JANUARY 23, 2024

The SLAS Ignite Theater ‘ Innovation & technology: from lab to patient ’, co-sponsored by Integra Biosciences and Hamamatsu Corporation, will take place at SLAS2024 in Boston on 5 and 6 February 2024. Developed by DDW in partnership with SLAS, the programme will feature leading research from experts in academia, government and industry.

Drug Development 130

Drug Development RNA Drugs Engineering 130

Broad Institute

SEPTEMBER 11, 2024

Azeet Narayan By Maria Nemchuk September 11, 2024 Goldberg SB, Narayan A, Kole AJ, et al. High-throughput RNA profiling via up-front sample parallelization. Senior Assay Research Scientist Azeet Narayan is a senior assay research scientist at the Broad Institute of MIT and Harvard. Clin Cancer Res. 2018;24(8):1872-1880.

DNA 52

DNA RNA Research Production 52

Broad Institute

JULY 19, 2024

By Boston Children's Hospital July 19, 2024 Credit: Scott-Hewitt N, et al. By Boston Children's Hospital July 19, 2024 Credit: Scott-Hewitt N, et al. Online June 27, 2024. DOI: 10.1016/j.cell.2024.05.058. 2024.05.058. C1q, produced by microglia (green and blue), interacts with neurons (purple and blue). DOI: 10.1016/j.cell.2024.05.058.

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Protein Production Hospitals RNA Production 111

Broad Institute

AUGUST 29, 2024

Georgia By amatosni@broadinstitute.org August 29, 2024 Georgia Georgia St. The lab's research focuses on how cells respond to maintain essential functions in changing environments. Their research identified six genes that were significantly alternatively spliced in response to temperature stress.

RNA 52

RNA Research 52

Broad Institute

AUGUST 29, 2024

The lab's research centers on how cells respond to maintain essential functions in changing environments. They analyzed RNA sequencing data from the cells of eight organisms, which were cultured at both normal and elevated temperatures, using the rMATS program to compare isoform abundance under these conditions.

RNA 52

RNA Research 52

Codon

AUGUST 26, 2024

The Coalition for Epidemic Preparedness Innovations (CEPI)—a nonprofit organization that funds vaccine research and development—thinks so. Many research groups are now making broad-spectrum antivirals inspired by the innate immune system, leveraging recent advances in chemistry and biology. This work is already underway.

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RNA Virus DNA Vaccine 87

Drug Discovery World

MAY 23, 2024

Reece Armstrong speaks to Samuel Deutsch , Chief Scientific Officer of Nutcracker Therapeutics about the RNA landscape and how it can benefit the development of immunotherapies. RA: What role does RNA play in the development of effective immunotherapies? RA: What lessons for RNA development did we learn from the Covid-19 pandemic?

RNA 147

RNA Therapies Engineering Disease 147

Broad Institute

JUNE 14, 2024

Some CRISPR screens may be missing cancer drug targets By Allessandra DiCorato June 14, 2024 Breadcrumb Home Some CRISPR screens may be missing cancer drug targets Current CRISPR guides don’t work equally well in cells from people of all ancestries, which could lead to false negative results.

Drugs 145

Drugs RNA DNA Research 145

Broad Institute

AUGUST 19, 2024

A common fatty acid may help restore healthy vaginal bacteria after infection By Ari Navetta August 19, 2024 Breadcrumb Home A common fatty acid may help restore healthy vaginal bacteria after infection Treatments using oleic acid, a naturally occurring oil used in cells, could improve treatment of recurrent bacterial vaginosis infections.

Hospitals 121

Hospitals Medical Schools Treatment Science 121

Drug Discovery World

AUGUST 22, 2024

Dr Rosenzweig-Lipson says: “We are at the forefront of drug development in an area of research called cellular rejuvenation, which is an approach that has the potential to address many diseases of ageing by restoring aged and injured cells to a more youthful and resilient state.

Therapies 147

Therapies DNA Disease RNA 147

Drug Target Review

MAY 24, 2024

2 AlphaFold 3 has been built to model DNA, RNA and smaller molecules (ligands). ChatGPT [Internet] 2024 [updated 2024 May 12; cited 2024 May] Available from: [link] 2 Howe NP, Thompson B. Nature [Internet] 2024 [updated 2024 May 8; cited 2024 May]. References 1 Wikipedia. Alphafold 3.0:

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RNA DNA Bioinformatics Science 59

Broad Institute

FEBRUARY 27, 2024

Broad-MIT Seminars in Chemical Biology By Rose Circeo February 27, 2024 Breadcrumb Home Research Broad-MIT Seminars in Chemical Biology MIT Chemistry and the Broad Institute host monthly seminars in chemical biology with the intent to hear from the thought-leaders and bring together chemical biologists from both academia and industry in the Boston/Cambridge (..)

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RNA DNA Regulations Disease 52

Drug Discovery World

JULY 2, 2024

DDW’s Diana Spencer takes a closer look into why Switzerland is such a life sciences powerhouse and how Swiss researchers are advancing new technology and tackling modern health challenges. Superlab Suisse, a provider of laboratory and research spaces, is a great example of this mix of regionality and reproducibility.

Science 147

Science Drugs Clinical Trials Licensing 147

Drug Target Review

AUGUST 28, 2024

We then incubate the cells to mature into ‘pro-regenerative’ macrophages and insert two RNA messages to produce two human proteins that will be expressed at the site of injury when these ‘engineered’ macrophages are given back to the patient. J Hep, 2024 (EASL ILC 2024 Abstract #LBP-007). Reference 1 Brennan P et al.,

Therapies 114

Therapies Disease Engineering Medical Schools 114

Drug Discovery World

AUGUST 29, 2024

For example, multiple RNA helicases are being targeted for cancer and viral infections before their catalytic properties are well understood. The company’s SimpleStep ELISA (SSE) kits are sandwich ELISA assays developed to cover over 900 key targets across research areas, including immunology, immuno-oncology and neuroscience.

Small Molecule 147

Small Molecule Drugs Protein Expression Assay Development 147

Drug Discovery World

SEPTEMBER 25, 2024

Figure 1: Major deals involving ADCs- 2024 Figure 2: Examples of FDA-approved ADCs – 2024 These include Johnson & Johnson’s $2 billion purchase of ADC specialist Ambrx in January, Genmab’s $1.8 This requires extensive preclinical research and validation.”

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Therapies Pharma Companies FDA Approval FDA 162

Drug Target Review

SEPTEMBER 25, 2024

2022 Dec 12 [cited 2024 Sep 4];22(3):213–34. 2019 Dec 13 [cited 2024 Sep 4];122(4):465–72. 2020 Dec 1 [cited 2024 Sep 4];20(12):743–56. 2021 Oct 11 [cited 2024 Sep 4];13(20):5081. 2021 Apr [cited 2024 Sep 4];2(4):377–91. Cancer research [Internet]. 2024 Mar 22 [cited 2024 Jul 8];84(6_Supplement):5891–1.

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Small Molecule Regulations Therapies Treatment 105

Alta Sciences

APRIL 16, 2024

Inside The Altascientist: The Benefits of PCR for Your Gene Therapy Programs pmjackson Tue, 04/16/2024 - 19:04 The gene therapy landscape continues to accelerate in preclinical and clinical research, with programs constantly in development for targeted, personalized medicines. But how are PCR analysis techniques applied?

Therapies 52

Therapies DNA RNA Laboratories 52

Broad Institute

JUNE 28, 2023

Today, scientists use these reactions to produce customizable DNA and RNA molecules that enable genetic sequencing, drug and vaccine development, pathogen tests, cancer diagnostics, and many aspects of basic biomedical research. “I Longer synthetic DNA and RNA molecules are also critical for modern biologic drugs.

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DNA RNA Science Therapies 98

Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus. Online July 11, 2024.

Treatment 72

Treatment Immune Response Virus Drugs 72

Drug Discovery World

MAY 13, 2024

For vaccine design, modern cryo-EM workflows allow researchers to quickly determine high resolution structures of relevant viral proteins, assess structure-function impact, and map binding for previously known broadly neutralising antibodies that are critical to vaccine design. MA: Respiratory viruses represent a diverse group of pathogens.

Vaccine 147

Vaccine Virus Small Molecule Disease 147

Drug Discovery World

JANUARY 21, 2024

Inspired by the overall event theme of ‘Innovation at Every Turn’, the DDW track will present leading research and case studies from experts in academia, government agencies and the industry on how technology is innovating from bench to bedside, lab to patient. It is sponsored by Integra Biosciences and Hamamatsu Corporation.

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Vaccine Computational Chemistry Animal Testing Engineering 130

Drug Discovery World

MARCH 13, 2024

Thanks to significant investment by the government into research and development, Singapore has become a leading centre for biomedical sciences in Asia. Leading the way in academic research One of Singapore’s key strengths is education and its academic prowess, particularly in cancer research.

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Government Science Pharmaceuticals Vaccine 173

Drug Discovery World

DECEMBER 26, 2023

Otsuka Pharmaceutical and Ionis Pharmaceuticals Otsuka Pharmaceutical and RNA therapy company Ionis have entered into a licence agreement for Otsuka to acquire exclusive marketing rights to Ionis’ hereditary angioedema (HAE) drug candidate donidalorsen in Europe. His research focuses on immunotherapies for patients with breast cancer.

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Small Molecule Drugs Molecular Biology Bioinformatics 130