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Prof Rory Johnson is an Associate Professor at University College Dublin, where his research focusses on uncovering the roles of long noncoding RNAs (lncRNAs) in human health and disease using an interdisciplinary combination of bioinformatic and experimental methods.
Recent advances in bioinformatics show clonal neoantigens are the best targets for immunotherapy, as I will elucidate below. Using powerful bioinformatics technology developed and validated with sequence data from the TRACERx study, researchers are able to identify clonal neoantigens from a patient’s unique tumour profile.
MIA: Noor Pratap Singh, RNA-Seq data using a tree-based framework; Primer: Rob Patro By Rose Circeo February 26, 2025 Breadcrumb Home MIA: Noor Pratap Singh, RNA-Seq data using a tree-based framework; Primer: Rob Patro Primer: Counting is not easy: Assessing and quantifying uncertainty in abundance inferences from high-throughput sequencing data Rob (..)
His leadership has driven international commercial success in areas including image analysis, data management, bioinformatics, advanced clinical trial data analysis leveraging machine learning and federated learning. 2024 [cited 2025 Feb 7]. Velez (2025). Using clinical genomics and AI in drug development to elevate success.
Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. Bioinformatics. Bioinformatics. Nucleic Acids Research.
Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. Bioinformatics. Bioinformatics. Nucleic Acids Research.
Surveys (eg, 2024 State of Tech in Biopharma Report ) predict a doubling of R&D data year-over-year in 2025, highlighting the continued growth of available data. This article, along with other insightful analyses, will be featured in our upcoming report, Beyond the Lab – Artificial Intelligence, launching on 21st March 2025.
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