Covalent Modifiers

DECEMBER 28, 2024

Ai-Lin Chen, Zih-Jheng Lin, Hsiao-Yu Chang, and Tsung-Shing Andrew Wang Journal of the American Chemical Society , 2025 [link] Reactive carbonyl species (RCS) are important biomarkers of oxidative stress-related diseases because of their highly reactive electrophilic nature.

Disease 182

Disease Production 182

Drugs.com

MARCH 8, 2025

SATURDAY, March 8, 2025 -- Cardiovascular disease is a general term that refers to many different types of heart problems.Heart disease is the No. In fact, one American dies from heart disease every 33. 1 cause of death in the United States.

Disease 165

Disease 165

Drugs.com

FEBRUARY 6, 2025

6, 2025 -- The U.S. THURSDAY, Feb. Food and Drug Administration has approved Onapgo (apomorphine hydrochloride) injection as the first and only subcutaneous apomorphine infusion device for the treatment of motor fluctuations in patients with.

FDA Approval 277

FDA Approval Disease FDA Treatment 277

BioPharma Drive: Drug Pricing

OCTOBER 18, 2024

Detailed data from a Phase 2b/3 study of Merck’s treatment clesrovimab should support the company’s efforts to win approval by the 2025-2026 season.

Hospitals 271

Hospitals Disease Trials Treatment 271

Drugs.com

MARCH 24, 2025

MONDAY, March 24, 2025 -- The U.S. Food and Drug Administration has approved Tremfya (guselkumab) for adult patients with moderately to severely active Crohn disease.This approval is the fourth indication for this dual-acting interleukin-23.

FDA Approval 227

FDA Approval Disease FDA Drugs 227

Elrig

MARCH 25, 2025

It will also cover recent advancements in broadening their application, including innovative approaches to ensure their safety and efficacy, the use of targeted delivery to reach disease-relevant tissues as well as success stories in bringing therapeutic oligonucleotides to the clinic.

RNA 59

RNA Bioinformatics Science Pharmacokinetics 59

Drugs.com

FEBRUARY 13, 2025

13, 2025 -- If you've got a big belly, diabetes or high blood pressure, you may want to limit your alcohol, experts warn, as drinking could significantly raise your odds for serious liver disease.The research, published recently in. THURSDAY, Feb.

Disease 245

Disease Research 245

Drugs.com

APRIL 4, 2025

FRIDAY, April 4, 2025 -- An experimental blood test for Alzheimers disease not only can aid in its diagnosis but also indicate how far the brain condition has progressed, a new study says.The test tracks levels of a protein called MTBR-tau243, w.

Disease 147

Disease 147

Drugs.com

JANUARY 6, 2025

6, 2025 -- Heart disease and cancer might seem completely unrelated, but these two top causes of death sometimes act in concert.Women with heart disease appear to have a greater risk of aggressive breast cancer, according to a new. MONDAY, Jan.

Disease 173

Disease 173

Drugs.com

MARCH 17, 2025

MONDAY, March 17, 2025 -- For 21 years, Sebastien Beauzile lived with the chronic pain of sickle cell anemia. Now, thanks to a groundbreaking genetic treatment, he is the first person in New York to be cured of the disease. Sickle cell was like.

Treatment 290

Treatment Disease 290

Covalent Modifiers

FEBRUARY 10, 2025

DOI Ansgar Oberheide, Maxime van den Oetelaar, Jakob Scheele, Jan Borggrfe, Semmy Engelen, Michael Sattler, Christian Ottmann, Peter Cossar and Luc Brunsveld RSC Med Chem 2025 [link] Protein-protein interactions (PPIs) are key regulators of various cellular processes.

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Biophysical Assays Small Molecule Engineering Regulations 173

Drugs.com

APRIL 1, 2025

TUESDAY, April 1, 2025 -- Hundreds of U.S. research projects aimed at boosting vaccine confidence have been shut down -- just as preventable diseases like measles and flu are on the rise. 20, the U.S. Department of Health and Human.

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Vaccine Disease Research 265

Drugs.com

MARCH 12, 2025

WEDNESDAY, March 12, 2025 -- Well-to-do and better-educated Americans have far lower rates of heart disease than the rest of the population, a new study says.The top 20% of high-income, college-educated Americans have less heart disease risk than.

Disease 147

Disease 147

Drugs.com

MARCH 26, 2025

WEDNESDAY, March 26, 2025 -- Preliminary data released this month by the U.S. Centers for Disease Control and Prevention indicate that more than 10,300 tuberculosis (TB) cases were reported last year, representing an 8 percent increase from 2023.

Disease 257

Disease 257

Drugs.com

JANUARY 2, 2025

2, 2025 -- Cases of a bacterial infection called rabbit fever have been increasing during the past decade.Cases of tularemia increased by 56% during the 2010s compared to the previous decade, researchers report in the CDCs Morbi. THURSDAY, Jan.

Disease 246

Disease Research 246

BioPharma Drive: Drug Pricing

JANUARY 9, 2025

Political and economic uncertainty hangs over the industry, while major bets on metabolic and immune disease drug research are set to play out.

Drug Research 173

Drug Research Disease Research Drugs 173

Drugs.com

MARCH 10, 2025

MONDAY, March 10, 2025 -- Sleep-deprived night shift nurses are at greater risk for the common cold and other infectious diseases, a new study says.Shift work and its impact on quality sleep can wreak havoc on nurses immune systems, making them m.

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Nurses Disease 147

Drugs.com

MARCH 24, 2025

MONDAY, March 24, 2025 -- A fake web page designed to look like the U.S. Centers for Disease Control and Prevention's (CDC) vaccine safety site has been taken down on orders from health secretary Robert F. Kennedy Jr.The site was linked to.

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Vaccine Disease 263

Covalent Modifiers

MARCH 8, 2025

4c02644 NADPH oxidases (NOXs) are enzymes dedicated to reactive oxygen species (ROS) production and are implicated in cancer, neuroinflammation, and neurodegenerative diseases. VAS2870 is a covalent inhibitor of mainly NOX2 and NOX5. It alkylates a conserved active-site cysteine, blocking productive substrate binding.

Production 130

Production Disease 130

Drugs.com

FEBRUARY 27, 2025

27, 2025 -- With egg prices soaring due to a severe bird flu outbreak, the U.S. Department of Agriculture (USDA) announced a $1 billion plan to contain the disease and help poultry farmers recover. THURSDAY, Feb. The outbreak has destroyed flocks.

Disease 291

Disease 291

Conversations in Drug Development Trends

NOVEMBER 5, 2024

In preparation for World Orphan Drug Congress Europe, we interviewed Nathan Chadwick, Senior Director, Therapeutic Strategy Lead, Rare Disease, and Derek Ansel, MS, LCGC, Vice President, Therapeutic Strategy Lead, Rare Disease, to hear their insights into the current progress in rare disease research and their hopes for 2025.

Disease 52

Disease Clinical Trials Therapies Clinical Research 52

Drugs.com

JANUARY 6, 2025

6, 2025 -- Rates of whooping cough in the U.S. continue to climb, according to data from the US Centers for Disease Control (CDC).Over MONDAY, Jan. Over 32,000 cases reported have been reported as of mid-December -- about six times more than there were.

Disease 289

Disease 289

Drugs.com

APRIL 1, 2025

TUESDAY, April 1, 2025 -- Microplastics appear to be contributing to chronic diseases in shoreline areas of the United States, a new study suggests.High blood pressure, diabetes and stroke rates are higher in coastal or lakefront areas with greater.

Disease 241

Disease 241

Drugs.com

JANUARY 16, 2025

16, 2025 -- The U.S. Food and Drug Administration has approved Omvoh (mirikizumab-mrkz) for the treatment of moderately to severely active Crohn disease in adults, according to a press release from Eli Lilly and Company.Omvoh targets. THURSDAY, Jan.

FDA Approval 162

FDA Approval Disease FDA Treatment 162

Drugs.com

MARCH 24, 2025

MONDAY, March 24, 2025 -- The best evidence yet that cutting-edge Alzheimers disease drugs might indeed ward off the degenerative brain disease has emerged from a small-scale study.An experimental drug that clears amyloid beta from the brain cut t.

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Drugs Disease 229

Drugs.com

FEBRUARY 28, 2025

28, 2025 -- As this year’s severe flu season rages across the country, federal health officials are investigating a rise in rare but life-threatening brain complications in children. Centers for Disease Control and. FRIDAY, Feb.

Disease 277

Disease 277

Drugs.com

MARCH 5, 2025

WEDNESDAY, March 5, 2025 -- A measles outbreak in Texas has grown to 159 cases, and now the U.S. Centers for Disease Control and Prevention (CDC) has sent a team to help local health officials respond.The CDC announced the plan on X, explaining.

Disease 278

Disease 278

Drugs.com

FEBRUARY 18, 2025

18, 2025 -- The U.S. Food and Drug Administration has approved Penmenvy (Meningococcal Groups A, B, C, W, and Y Vaccine) for active immunization against invasive meningococcal disease (IMD), according to a press release from. TUESDAY, Feb.

FDA Approval 274

FDA Approval Vaccine FDA Disease 274

Drugs.com

FEBRUARY 5, 2025

5, 2025 -- Hopes that GLP-1 drugs such as Ozempic and Wegovy could help slow Parkinson's disease have taken an hit.A WEDNESDAY, Feb. new study found that a drug in the same class called exenatide, marketed as Byetta, had no effect on slowing the.

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Drugs Disease Marketing 276

Covalent Modifiers

MARCH 1, 2025

Zhang, and Lun Kelvin Tsou Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02665 4c02665 Pharmacological inhibition of the cGAS-STING-controlled innate immune pathway is an emerging therapeutic strategy for a myriad of inflammatory diseases. Here, we report GHN105 as an orally bioavailable covalent STING inhibitor.

Disease 130

Disease Treatment 130

Drugs.com

MARCH 27, 2025

THURSDAY, March 27, 2025 -- The U.S. Centers for Disease Control and Prevention (CDC) is facing major changes, with five senior leaders stepping down Tuesday. These exits follow three other recent departures, meaning that as many as one-third of.

Disease 229

Disease 229

Drugs.com

FEBRUARY 11, 2025

11, 2025 -- Ozempic, Wegovy, Saxenda, Trulicity: These and other GLP1-RA diabetes/weight-loss meds can also boost outcomes for folks battling chronic kidney disease, new research shows.Compared to another common class of kidney. TUESDAY, Feb.

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Disease Research 269

Science Daily: Pharmacology News

JANUARY 16, 2025

The American Cancer Society (ACS) today released Cancer Statistics, 2025, the organization's annual report on cancer facts and trends. However, this steady progress is jeopardized by increasing incidence for many cancer types, especially among women and younger adults, shifting the burden of disease. million deaths.

Disease 296

Disease 296

Drugs.com

FEBRUARY 16, 2025

16, 2025 -- Flu season is in full swing, making it more important than ever to take steps to protect yourself and your loved ones.Dr. Priya Soni, a pediatric infectious disease specialist at Cedars-Sinai Guerin Childrens Health Center. SUNDAY, Feb.

Disease 266

Disease 266

Drugs.com

JANUARY 17, 2025

17, 2025 -- The U.S. Centers for Disease Control and Prevention (CDC) confirmed another human H5N1 avian flu case -- otherwise known as bird flu -- in California on Thursday, bringing the nationwide total of cases to 67.California FRIDAY, Jan. California has.

Disease 264

Disease 264

Drugs.com

JANUARY 28, 2025

28, 2025 -- An experimental blood test can effectively and accurately detect colon cancer in middle-aged folks and seniors, a new study says.The blood test was 81% accurate in detecting colon cancer among people who have the disease. TUESDAY, Jan.

Disease 264

Disease 264

Drugs.com

MARCH 3, 2025

MONDAY, March 3, 2025 -- A patient with multiple autoimmune diseases can remember the exact moment a doctor tore their heart out.One doctor told me I was making myself feel pain, and I still cant forget those words, the patient remembered.

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Doctors Disease 264