Broad Institute

MARCH 27, 2025

Building bridges between Denmark-based and Broad researchers By Corie Lok March 27, 2025 Breadcrumb Home Building bridges between Denmark-based and Broad researchers The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease is forging connections between Danish and Broad scientists. Here are two of their stories.

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Research DNA Regulations Disease 52

Drug Target Review

JULY 1, 2024

As a non-NSAID, it reduces adverse effects associated with these pain relief drugs, including kidney injury, GI gastritis/ulceration and blood pressure elevation, which can affect patients with cardiovascular disease and the elderly. We set out to improve health by developing a novel non-opioid that avoids potential abuse.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

Codon

MAY 15, 2023

Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. Cell Systems. Cell Systems. From the team at Sherlock Biosciences.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. Cell Systems. Cell Systems. From the team at Sherlock Biosciences.

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DNA Bioinformatics Engineering Virus 52

Broad Institute

JANUARY 16, 2025

By Allessandra DiCorato January 16, 2025 Credit: Scott Sassone, Broad Communications Tara McDonald (left) and Steve McCarroll (right) are coauthors of a new paper describing a biological mechanism underlying Huntington's disease. The cumulative death of many such cells leads to the symptoms of Huntingtons disease.

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Broad Institute

JANUARY 7, 2025

A clinical genomicist harnesses team-based science to help rare-disease patients By Allessandra DiCorato January 7, 2025 Breadcrumb Home A clinical genomicist harnesses team-based science to help rare-disease patients Heidi Rehm convinced labs and scientists to work together and share data.

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Disease Science Laboratories Medical Schools 121

Broad Institute

JANUARY 27, 2025

A genome-wide atlas of cell morphology reveals gene functions By Allessandra DiCorato January 27, 2025 Breadcrumb Home A genome-wide atlas of cell morphology reveals gene functions PERISCOPE, a technique for genome-wide imaging screens, is helping Broad scientists understand the connections between genes and traits. Online January 27, 2025.

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DNA RNA Science Research 131

Elrig

MARCH 10, 2025

Research & Innovation 2025 Keynote Speakers Announced Cambridge, UK, 24 January 2025: The European Laboratory Research & Innovation Group (ELRIG), a not-for-profit, volunteer-led organisation for the drug discovery community, today announced the keynote speakers for Research & Innovation 2025.

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Research Laboratories Medical Schools Engineering 52

Drug Target Review

APRIL 1, 2025

Advances in biotechnology are driving significant progress in the treatment of rare diseases, making it possible to develop targeted therapies for previously untreatable conditions. Our vision for 2025 is to get into the clinic with our candidate drug for tackling H-ABC. It also received two grants from Innovate UK, totalling 2.5

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

Broad Institute

MARCH 27, 2025

A Novo Nordisk - Broad collaboration is connecting Denmark-based and Broad researchers By Corie Lok March 27, 2025 Breadcrumb Home A Novo Nordisk - Broad collaboration is connecting Denmark-based and Broad researchers The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease has built a bridge between Danish and Broad scientists.

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Research DNA Regulations Disease 75

keypoint

JANUARY 8, 2025

Our first Fellows Spotlight of 2025 goes to Keystone Symposia Fellow Dr. Abigael Cheruiyot! Studying RNA surveillance mechanisms, they identified nonsense mediated decay as a potential target for novel cancer therapies. She is very passionate about both science and promoting equity within the research community.

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Medical Schools RNA Laboratories Doctors 59

Codon

JANUARY 26, 2025

Astrologers of the time believed that the disease’s periodic return was influenced by the location of the stars. By contrast, smallpox and measles vaccines are more than 95 percent effective at preventing disease, a level sufficient to have eradicated smallpox entirely. Formaldehyde had precedent in medicine.

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Vaccine Immune Response Virus Clinical Trials 98

Codon

FEBRUARY 19, 2025

Researchers today often spend months trying to figure out whether a genetic mutation causes disease, simply because laboratory experiments are slow. ESM is a protein language model that captures certain aspects of protein structure and function, for example, but is blind to DNA or RNA-level features that drive cell behavior.

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DNA Laboratories Engineering RNA 99

Codon

FEBRUARY 5, 2025

Animal models that suffer from the same diseases as humans are perhaps our most valuable resources for studying those conditions. Animals develop diseases more quickly than humans do. They can also be tracked continuously throughout the course of a disease and (unwittingly) serve as test subjects for risky, experimental treatments.

Disease 52

Disease Treatment Research RNA 52

Drug Target Review

DECEMBER 16, 2024

For patients with aggressive diseases, the waiting time for CAR T-cell treatment may be too long. Lentiviral platforms offer the potential of a one-time treatment to generate long-lasting CAR T cells in a patients body, while other RNA-based platforms offer an approach that uses repeat dosing for short-term generation of CAR T cells.

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Therapies Clinical Trials Treatment Trials 52

Drug Target Review

NOVEMBER 27, 2024

For example, the European Medicines Agency (EMA), in its Regulatory Science Strategy to 2025 , has highlighted the critical role of biomarker discovery, qualification and utilisation in accelerating precision medicine. Finally, its application in urine samples presents additional challenges compared to serum.

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Drug Development Regulations Laboratories FDA 52

Codon

DECEMBER 1, 2024

Many students are taught that the Central Dogma is simply “DNA → RNA → protein.” In 1956, Crick was working on a lecture that would bring together what was then known about the “flow of information” between DNA, RNA, and protein in cells.

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RNA DNA Molecular Biology Virus 129

Codon

FEBRUARY 23, 2025

In January 2025, the incoming Trump administration issued a 90-day freeze on PEPFAR while it conducts a “programmatic efficiencies” review. Since zidovudine failed to interfere with DNA-to-DNA replication, Ostertag wondered if it could block RNA-to-DNA replication instead. By February, the U.S. Subscribe to Asimov Press!

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Clinical Trials Virus Vaccine DNA 68