Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. Merkin Prize in Biomedical Technology for his development of an efficient, scalable method of producing RNA and proteins in the laboratory.

RNA 84

RNA Production Molecular Biology Laboratories 84

Broad Institute

FEBRUARY 24, 2025

Although this ancestral replicase appears to have been lost, key aspects of RNA-catalyzed RNA replication can be studied by proxy with the use of modern RNA enzymes (ribozymes) generated by in vitro evolution. However, none of these RPRs was capable of self-replication.

RNA 52

RNA Molecular Biology Laboratories Engineering 52

Broad Institute

OCTOBER 16, 2024

William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines The groundbreaking, scalable technology is widely used in laboratories around the world today to efficiently produce large amounts of protein and RNA. Merkin (left) and F.

Vaccine 64

Vaccine RNA Laboratories Molecular Biology 64

Drug Target Review

JULY 1, 2024

Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing. He was bestowed the 2024 NIH HEAL Director’s Trailblazer Award for this work.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

Broad Institute

APRIL 3, 2025

Scientists have developed a way to scale up spatial genomics and lower costs By Allessandra DiCorato April 3, 2025 Breadcrumb Home Scientists have developed a way to scale up spatial genomics and lower costs A new computational approach eliminates time-intensive imaging, enabling high-resolution spatial mapping of gene expression in tissue.

DNA 119

DNA RNA Molecular Biology Laboratories 119

Broad Institute

JANUARY 7, 2025

A clinical genomicist harnesses team-based science to help rare-disease patients By Allessandra DiCorato January 7, 2025 Breadcrumb Home A clinical genomicist harnesses team-based science to help rare-disease patients Heidi Rehm convinced labs and scientists to work together and share data.

Disease 121

Disease Science Laboratories Medical Schools 121

Codon

DECEMBER 1, 2024

By Matthew Cobb The Central Dogma is a linchpin for understanding how cells work, and yet it is one of the most widely misunderstood concepts in molecular biology. Many students are taught that the Central Dogma is simply “DNA → RNA → protein.”

RNA 131

RNA DNA Molecular Biology Virus 131