Broad Institute

FEBRUARY 26, 2025

To address these challenges, we introduce a data-driven tree-based framework that incorporates uncertainty into RNA-seq data analysis. In the first part of the talk, I will discuss existing approaches for handling uncertainty and their limitations in RNA-seq data analysis before introducing TreeTerminus.

RNA 52

RNA Bioinformatics Science International 52

Fierce BioTech

JULY 1, 2024

Streamlining the Path from Discovery to Patient – Simpler RNA Manufacturing with Aldevron’s Codex® HiCap RNA Polymerase swheeler Mon, 07/01/2024 - 17:17 Wed, 08/07/2024 - 10:00 Resource Type Webinar Kyle Studey, M.S. Codex ® is a trademark of Codexis, Inc. Listing Image aldevron 250x190.png

RNA 40

RNA Engineering Research 40

Alta Sciences

FEBRUARY 19, 2025

Regulatory Guidance for Oligonucleotide Bioanalysis in Drug Development pmjackson Wed, 02/19/2025 - 21:30 The unique physicochemical properties of oligonucleotides require the use of specialized bioanalytical approaches, with key considerations including selectivity and specificity, sensitivity, stability, and matrix effects.

Drug Development 52

Drug Development Clinical Pharmacology Immune Response Drugs 52

Broad Institute

FEBRUARY 24, 2025

Although this ancestral replicase appears to have been lost, key aspects of RNA-catalyzed RNA replication can be studied by proxy with the use of modern RNA enzymes (ribozymes) generated by in vitro evolution. However, none of these RPRs was capable of self-replication.

RNA 52

RNA Molecular Biology Laboratories Engineering 52

Fierce BioTech

MARCH 14, 2025

Advancing the Future of Biomarker-Driven Immunotherapy swheeler Fri, 03/14/2025 - 13:43 Mon, 04/21/2025 - 12:00 Resource Type Webinar Eduard Porta-Pardo Can spatial biomarkers revolutionize patient stratification for immune checkpoint inhibitors? On Demand Start Date Mon, 04/21/2025 - 13:00 End Date/Time Mon, 04/21/2025 - 13:00

RNA 59

RNA Clinical Trials Therapies Trials 59

Broad Institute

FEBRUARY 11, 2025

Mapping mRNA through its life cycle within a cell By Corie Lok February 11, 2025 Breadcrumb Home Mapping mRNA through its life cycle within a cell Xiao Wangs studies of how and where RNA is translated could lead to the development of better RNA therapeutics and vaccines.

RNA 52

RNA DNA Science Vaccine 52

Broad Institute

OCTOBER 16, 2024

William Studier receives the 2024 Merkin Prize in ceremony at the Broad Institute for developing technology used to produce millions of doses of COVID-19 vaccines The groundbreaking, scalable technology is widely used in laboratories around the world today to efficiently produce large amounts of protein and RNA. Merkin (left) and F.

Vaccine 64

Vaccine RNA Laboratories Molecular Biology 64

Drug Target Review

NOVEMBER 29, 2023

Our primary focus is to design and develop RNA therapies for liver diseases. When combined with our in-house GMP-level RNA chemistry lab, Ochre Bio is able to progress from a new target to generating human data on a lead therapy in days. What does Ochre Bio do, can you give me an overview of your work?

Therapies 102

Therapies Disease RNA Engineering 102

Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). The 2025 genetic network paper fit that bill exactly. There was scFormer in 2022, scGPT in 2023, and plenty of others. As such, they were quietly abandoned.

Engineering 140

Engineering Virus DNA Therapies 140

LifeSciVC

JANUARY 16, 2024

While names like DNLI, JNJ, DYN, and RNA were real pioneers in the space for delivery of antibodies and oligos, more and more companies are developing their own TfR1 shuttles or partnering to bring in the capability. TfR1 is almost becoming table stakes for Pharma and biotech looking to deliver to the brain and / or muscle.

Small Molecule 140

Small Molecule Trials Therapies Disease 140

Broad Institute

MARCH 27, 2025

Building bridges between Denmark-based and Broad researchers By Corie Lok March 27, 2025 Breadcrumb Home Building bridges between Denmark-based and Broad researchers The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease is forging connections between Danish and Broad scientists. Here are two of their stories.

Research 52

Research DNA Regulations Disease 52

Drug Target Review

JULY 1, 2024

Using the 10X Genomics Chromium platform, we conducted ribonucleic acid (RNA) sequencing on the midbrain’s PAG region in animals treated with SRP-001, ApAP and a vehicle control, focusing on gene expression changes related to pain processing.

Treatment 59

Treatment Clinical Trials Therapies Molecular Biology 59

Codon

MAY 15, 2023

Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. Cell Systems. Cell Systems. From the team at Sherlock Biosciences.

DNA 52

DNA Bioinformatics Engineering Virus 52

Codon

MAY 15, 2023

Made from a Cas9 nickase (the histidine at amino acid position 840 is swapped for an alanine) fused to a reverse transcriptase enzyme (which makes DNA from RNA; transcription in reverse), prime editing clinical trials are expected to begin by 2025. Cell Systems. Cell Systems. From the team at Sherlock Biosciences.

DNA 52

DNA Bioinformatics Engineering Virus 52

Elrig

MARCH 10, 2025

Research & Innovation 2025 Keynote Speakers Announced Cambridge, UK, 24 January 2025: The European Laboratory Research & Innovation Group (ELRIG), a not-for-profit, volunteer-led organisation for the drug discovery community, today announced the keynote speakers for Research & Innovation 2025.

Research 52

Research Laboratories Medical Schools Engineering 52

Broad Institute

APRIL 3, 2025

Scientists have developed a way to scale up spatial genomics and lower costs By Allessandra DiCorato April 3, 2025 Breadcrumb Home Scientists have developed a way to scale up spatial genomics and lower costs A new computational approach eliminates time-intensive imaging, enabling high-resolution spatial mapping of gene expression in tissue.

DNA 86

DNA RNA Molecular Biology Laboratories 86

Broad Institute

JANUARY 16, 2025

By Allessandra DiCorato January 16, 2025 Credit: Scott Sassone, Broad Communications Tara McDonald (left) and Steve McCarroll (right) are coauthors of a new paper describing a biological mechanism underlying Huntington's disease. Online January 16, 2025. Funding This work was supported by CHDI Foundation, Inc., DOI: 10.1016/j.cell.2024.11.038.

Disease 130

Disease DNA Medical Schools RNA 130

Broad Institute

JANUARY 27, 2025

A genome-wide atlas of cell morphology reveals gene functions By Allessandra DiCorato January 27, 2025 Breadcrumb Home A genome-wide atlas of cell morphology reveals gene functions PERISCOPE, a technique for genome-wide imaging screens, is helping Broad scientists understand the connections between genes and traits. Online January 27, 2025.

DNA 131

DNA RNA Science Research 131

Broad Institute

FEBRUARY 5, 2025

Mutations in two gene pairs point to a promising drug target in 5 percent of adult cancers By Allessandra DiCorato February 5, 2025 Breadcrumb Home Mutations in two gene pairs point to a promising drug target in 5 percent of adult cancers Targeting the PELO gene could be a way to kill tumor cells in cancers with one of two common genetic mutations.

Protein Production 100

Protein Production DNA Drugs RNA 100

keypoint

JANUARY 8, 2025

Our first Fellows Spotlight of 2025 goes to Keystone Symposia Fellow Dr. Abigael Cheruiyot! Studying RNA surveillance mechanisms, they identified nonsense mediated decay as a potential target for novel cancer therapies. She is very passionate about both science and promoting equity within the research community.

Medical Schools 59

Medical Schools RNA Laboratories Doctors 59

Codon

FEBRUARY 16, 2025

Building a Circuit Much like electronic circuits, which use wires and transistors to create or process signals, a synthetic gene circuit is a network of biological parts — DNA, RNA, and proteins — that process inputs and generate outputs. Also, RNA polymerase moves in bursts along DNA, rather than at a steady pace.

DNA 80

DNA RNA Engineering Small Molecule 80

Broad Institute

MARCH 27, 2025

A Novo Nordisk - Broad collaboration is connecting Denmark-based and Broad researchers By Corie Lok March 27, 2025 Breadcrumb Home A Novo Nordisk - Broad collaboration is connecting Denmark-based and Broad researchers The Novo Nordisk Foundation Center for Genomic Mechanisms of Disease has built a bridge between Danish and Broad scientists.

Research 72

Research DNA Regulations Disease 72

Drug Target Review

APRIL 1, 2025

In this interview, Williams shares the companys plans for 2025, the challenges of treating rare diseases, and how gene-silencing technology could unlock new treatment options. Vision for 2025: A major step towards clinical trials Since its founding, SynaptixBio has made significant progress in advancing its research and development efforts.

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

Broad Institute

JANUARY 7, 2025

A clinical genomicist harnesses team-based science to help rare-disease patients By Allessandra DiCorato January 7, 2025 Breadcrumb Home A clinical genomicist harnesses team-based science to help rare-disease patients Heidi Rehm convinced labs and scientists to work together and share data.

Disease 121

Disease Science Laboratories Medical Schools 121

Codon

FEBRUARY 19, 2025

ESM is a protein language model that captures certain aspects of protein structure and function, for example, but is blind to DNA or RNA-level features that drive cell behavior. Evo 2 was trained on DNA sequences but can make predictions about myriad aspects of biology, including RNA stability and protein structures. & McCarty N.

DNA 99

DNA Laboratories Engineering RNA 99

Codon

JANUARY 26, 2025

The 2024-2025 seasonal vaccines include three viruses; two influenza A strains (H1N1 and H3N2) and an influenza B virus. RNA polymerase — the enzyme responsible for replicating influenza’s genetic material — lacks proofreading abilities, meaning that mutations aren’t corrected and can rapidly accumulate.

Vaccine 98

Vaccine Immune Response Virus Clinical Trials 98

Drug Target Review

DECEMBER 16, 2024

Lentiviral platforms offer the potential of a one-time treatment to generate long-lasting CAR T cells in a patients body, while other RNA-based platforms offer an approach that uses repeat dosing for short-term generation of CAR T cells. Umoja aims to dose its first patients near the end of 2024 with clinical updates expected in 2025.

Therapies 52

Therapies Clinical Trials Treatment Trials 52

Drug Target Review

NOVEMBER 27, 2024

For example, the European Medicines Agency (EMA), in its Regulatory Science Strategy to 2025 , has highlighted the critical role of biomarker discovery, qualification and utilisation in accelerating precision medicine.

Drug Development 52

Drug Development Regulations Laboratories FDA 52

Codon

FEBRUARY 5, 2025

The researchers also ran follow-up experiments in the laboratory; cell lines carrying the same mutations as those found in the monkey had similar RNA expression patterns as cells taken from Parkinson’s patients. ” Asimov Press (2025). If you’re interested, please contact him at trevor[at]highwaypharm.com.

Disease 52

Disease Treatment Research RNA 52

Codon

DECEMBER 1, 2024

Many students are taught that the Central Dogma is simply “DNA → RNA → protein.” In 1956, Crick was working on a lecture that would bring together what was then known about the “flow of information” between DNA, RNA, and protein in cells.

RNA 128

RNA DNA Molecular Biology Virus 128

Codon

FEBRUARY 23, 2025

In January 2025, the incoming Trump administration issued a 90-day freeze on PEPFAR while it conducts a “programmatic efficiencies” review. Since zidovudine failed to interfere with DNA-to-DNA replication, Ostertag wondered if it could block RNA-to-DNA replication instead. ” Asimov Press (2025).

Clinical Trials 68

Clinical Trials Virus Vaccine DNA 68