Improving quality control for CAR T cell therapies
Drug Discovery World
AUGUST 10, 2022
For example, it is challenging to regulate transgene copy numbers in each T cell, posing safety risks. If the gene does not integrate into the genome, the cell will not become a CAR T cell. But if the cell accepts too many copies of the gene, the cell can cause cytokine release syndrome (CRS) or a ‘cytokine storm’.
246 
Let's personalize your content