Improving quality control for CAR T cell therapies
Drug Discovery World
AUGUST 10, 2022
CAR T cells are made by transfecting T cells with a transgene that encodes the CAR protein using either a virus, a transposon system, or mRNA. MOI is the ratio between virus concentration and cell concentration, and with ddPCR assays, the researchers found that as MOI increased, so did copy number.
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