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billion USD by 2028. Large molecules are less able to penetrate the blood/brain barrier to deliver therapeutic results and thus most CNS-active drugs are smallmolecules.” --The Altascientist, Issue 33, pg. billion USD in 2023 to $166.53
It hopes to raise about $160 million in aggregate principal amount of 7.375% senior notes due 2025 and $270 million in aggregate principal amount of 7.250% senior notes due 2028. Its lead candidate is CLN-081, an oral smallmolecule designed to be a next-generation, irreversible EGFR inhibitor.
It is estimated that there will potentially be 13 million moderate-to-severe acne patients treated with oral antibiotics in the urban Chinese population by 2028, which represents a significant opportunity to launch an innovative product whose clinical development is largely de-risked.
27 key programs highlighted, including assets that could potentially contribute revenue by 2025 and others in the 2026-2028 time frame. Phase 1 data and development plans for danuglipron (PF-06882961), which has the potential to be the first-ever smallmolecule oral GLP-1RA for treating obesity and type 2 diabetes.
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