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Early phase support for plasmid DNA supply to secure future manufacturing

Drug Discovery World

This paid-for advertorial by Catalent appeared in DDW Volume 24 – Issue 1, Winter 2022/2023 One significant challenge in the manufacturing of cell and gene therapies is the production of high-quality plasmid DNA (pDNA). billion by 2030 (BioSpace, 11 August 2022). billion by 2030 (BioSpace, 11 August 2022).

DNA 130
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A vaccine for the ‘previously undruggable’ is just a decade away 

Drug Discovery World

In an exclusive interview with The Guardian, Moderna said that cancer and heart disease vaccines would be ready by 2030 1. Dr Paul Burton, the Chief Medical Officer of Moderna, told the Guardian: “We will have that vaccine and it will be highly effective, and it will save many hundreds of thousands, if not millions of lives.

Vaccine 130
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Tagging Essential Malaria Genes to Advance Drug Development

NIH Director's Blog: Drug Development

So, researchers have been searching the genome of Plasmodium falciparum , the most-lethal species of the malaria parasite, for potentially better targets for drug or vaccine development. That list of 2,680 essential genes now becomes an important starting point for future research as well as drug and vaccine development.

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Advances in cell line development

Drug Discovery World

billion in 2022, a figure that is expected to grow at a compound annual growth rate (CAGR) of 9.81% from 2023 to 2030 1. One of the most recent drivers of the cell line development market came from the Covid-19 pandemic, where research into vaccines skyrocketed and demand for cell lines was boosted as a result.

Vaccine 147
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India: Why is the country ramping up drug discovery research?

Drug Discovery World

In the global pharmaceuticals market, India ranks third worldwide for production by volume and the domestic pharmaceutical market is expected to reach US$120-130 billion by 2030 1. DDW’s Megan Thomas takes a deeper look into why India is ramping up drug discovery research, and explores the country’s innovation hubs of interest.

Research 130
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National Cancer Research Month: Celebrating drug discovery innovation

Drug Discovery World

Very recent data from Moderna’s and BioNTech’s personalised vaccines in combination with ICIs in melanoma and pancreatic cancer respectively have shown dramatic improvements when given as part of a triple combination (vaccine plus ICI and chemo/radiotherapy).

Research 130
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Beyond Steel Tanks

Codon

market with Wegovy will, by 2030, require about one million liters of production capacity. Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. The total global bioprocessing capacity was estimated at 17.4 But cell-free extracts can go much further.