Trending Articles

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Too Much Acetaminophen Could Harm Seniors' Health

Drugs.com

TUESDAY, Dec. 24, 2024 -- New British research shows that too much of a good medication can be a bad thing.In the study, repeated doses of paracetamol, known as acetaminophen (brand name Tylenol) in the United States, raised the risk of.

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Crossing the Uncanny Valley: Breakthrough in technology for lifelike facial expressions in androids

Science Daily: Pharmacology News

Even highly realistic androids can cause unease when their facial expressions lack emotional consistency. Traditionally, a 'patchwork method' has been used for facial movements, but it comes with practical limitations. A team developed a new technology using 'waveform movements' to create real-time, complex expressions without unnatural transitions.

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Tinkering with the 'clockwork' mechanisms of life

Science Daily: Pharmacology News

Opening new doors for the development of nanotechnologies in medicine and other fields, scientists recreate and compare two natural mechanisms to better program the timescale of molecular communication and functionality.

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FDA Updates Meaning of 'Healthy' on Food Labels

Drugs.com

THURSDAY, Dec. 19, 2024 (HeathDay News) -- The U.S. Food and Drug Administration wants to redefine the meaning of healthy food, issuing a new rule Thursday that changes the way food companies can claim their products are indeed nutritious.What foods.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Novo’s next-gen obesity drug misses expectations in closely watched trial

BioPharma Drive: Drug Pricing

Novo shares lost nearly a quarter of their value after an experimental combination treatment called cagrisema fell short of the bar set by executives.

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Universal Design for Visual Disabilities in Healthcare – Addressing Complete Blindness – 6

Perficient: Drug Development

Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. Creating an inclusive healthcare environment for individuals with complete blindness is a fundamental aspect of universal design. These individuals rely heavily on non-visual cues to navigate, access information, and communicate effectively.

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Origins of lunar water and its connection to Earth's early history

Science Daily: Pharmacology News

Scientists have unveiled groundbreaking research on the origins of lunar water, offering insights that could reshape our understanding of the Earth-Moon system and the broader solar system. The pioneering study explores the isotopic signatures of lunar water, revealing a mix of indigenous and cometary sources.

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Zepbound, Mounjaro shortages are resolved, FDA confirms

BioPharma Drive: Drug Pricing

The FDA’s decision will close a lucrative market opportunity for compounding pharmacies, although the agency will give a limited grace period before taking any enforcement actions.

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Microbiological Applications: Bacterial Metabolism | BMG LABTECH

BMG Labtech

Bacterial metabolism applications Bacterial metabolism spans the complex interconnected set of chemical reactions that support life in bacteria, ancient single-celled organisms that represent one of the most diverse forms of life on Earth. Bacterial metabolism is the foundation for bacterial growth and is inextricably linked to other organisms in the ecosystem.

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New research improves the safety and effectiveness of ADC cancer treatments

Drug Target Review

Antibody-drugconjugates (ADCs) represent a significant advancement in drug discovery, combining the precision of monoclonal antibodies with the cancer-killing power of cytotoxic drugs. While these therapies hold great promise for improving cancer treatment outcomes, their development presents significant challenges, especially in achieving the optimal balance between efficacy and safety.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Mysteries of icy ocean worlds

Science Daily: Pharmacology News

A study introduces a novel thermodynamic concept called the 'centotectic' and investigates the stability of liquids in extreme conditions -- critical information for determining the habitability of icy moons like Europa.

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Autism Tops List of Worldwide Youth Health Issues

Drugs.com

MONDAY, Dec. 23, 2024 -- Autism ranks among the top ten health problems for young people under 20.A new study published recently in The Lancet Psychiatry says that nearly 62 million people in 2021 had autism spectrum disorder.We estimated one in 1.

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Covalent Proximity Inducers

Covalent Modifiers

Nir London Chemical Reviews Article ASAP DOI: 10.1021/acs.chemrev.4c00570 Molecules that are able to induce proximity between two proteins are finding ever increasing applications in chemical biology and drug discovery. The ability to introduce an electrophile and make such proximity inducers covalent can offer improved properties such as selectivity, potency, duration of action, and reduced molecular size.

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A venture firm breathes new life into an old NGM drug

BioPharma Drive: Drug Pricing

An startup formed by KdT Ventures intends to test the drug, which was once licensed to Merck and evaluated in multiple metabolic disorders, for an unspecified rare conditon.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Keypoint Newsletter: Introducing the New Fellows Class of 2025

keypoint

Meet the Keystone Symposia Fellows Class of 2025, a stellar group of post-doctoral fellows and early-career scientists who will take part in this prestigious mentorship program.

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Antibody that neutralizes inhibitory factors involved in nerve regeneration leads to enhanced motor function after acute spinal cord injury

Science Daily: Pharmacology News

Antibodies can improve the rehabilitation of people with acute spinal cord injury. Researchers have investigated this with promising results. For the first time, it was possible to identify patient groups that displayed a clinically relevant treatment effect.

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Tea and Coffee May Help Protect You From Some Cancers

Drugs.com

THURSDAY, Dec. 26, 2024 -- That morning cup of coffee or afternoon spot of tea might be protecting you from cancer.A new evidence review says that coffee and tea consumption are linked to a lower risk of cancers of the mouth, throat, and head and.

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Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug Discovery

Covalent Modifiers

F angyuan Chen, Qingmei Liu, Lei Ma, Cuishi Yan, Haiman Zhang, Zhi Zhou, and Wei Yi Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.4c02803 Recent studies have identified selective peroxisome proliferator-activated receptor (PPAR) modulators, which synergistically engage in the inhibition mechanism of PPAR-Ser273 phosphorylation, as a promising approach for developing safer and more effective antidiabetic drugs.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Regeneron says study data support big bet on new blood thinners

BioPharma Drive: Drug Pricing

The company is planning a “broad Phase 3 program” for two anticoagulants after they outperformed marketed medicines in a pair of mid-stage trials.

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Drug Patent Expirations for the Week of December 22, 2024

Drug Patent Watch

VICTRELIS (boceprevir) Merck sharp dohme Patent: RE43298 Expiration: Dec 22, 2024 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.com or visit www.DrugPatentWatch.

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A festive flying reptile family reunion 150 million years in the making

Science Daily: Pharmacology News

A new study finds nearly 50 hidden relatives of Pterodactylus, the first pterosaur. Joined by its newly discovered relatives, Pterodactylus's 'family' now encompasses tiny flaplings, a host of teenagers, some mums and dads and even a few large old seniors. Fluorescing bones stimulated by powerful LED UV torches, revealed invisible details of the head, hands and feet of Pterodactylus.

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GLP-1 Receptor Agonist Zepbound Approved as First Drug for Obstructive Sleep Apnea in Individuals with Obesity

Drugs.com

MONDAY, Dec. 23, 2024 -- The U.S. Food and Drug Administration (FDA) has approved the first prescription medication specifically for treating obstructive sleep apnea (OSA): the weight-loss drug Zepbound. In a news release published Dec. 20, the FDA.

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Curves Module Insights

Collaborative Drug

Learn how CDD Vault is utilizing Curves to improve your drug discovery process.

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Novartis shutters MorphoSys sites, lays off staff

BioPharma Drive: Drug Pricing

While the pharma is still developing a MorphoSys drug acquired in its $2.9 billion deal for the biotech, it is closing down sites in the U.S. and Germany.

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Keypoint Newsletter: A Message from Our CEO

keypoint

Keystone Symposia CEO shares his first impressions, improvement and initiatives that will be implemented in 2025.

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Growing safer spuds: Removing toxins from potatoes

Science Daily: Pharmacology News

Scientists have discovered a way to remove toxic compounds from potatoes and tomatoes, making them safer to eat and easier to store. The breakthrough could cut food waste and enhance crop farming in extreme environments, like outer space.

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FDA Approves First Generic of GLP-1 Receptor Agonist Victoza (liraglutide injection) to Lower Blood Sugar in Patients with Type 2 Diabetes

Drugs.com

December 23, 2024 -- Today, the U.S. Food and Drug Administration approved the first generic referencing Victoza (liraglutide injection) 18 milligram/3 milliliter, a glucagon-like peptide-1 (GLP-1) receptor agonist indicated to improve glycemic.

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Discovery and biological evaluation of potent 2-trifluoromethyl acrylamide warhead-containing inhibitors of protein disulfide isomerase

Covalent Modifiers

Jung-Chun Chu, Keng-Chang Tsai, Ting-Yu Wang, Tzu-Yin Chen, Ju-Ying Tsai, Tien Lee, Mei-Hsiang Lin, Yves S.Y. Hsieh, Chin-Chung Wu, Wei-Jan Huang, European Journal of Medicinal Chemistry , 283, 2025 , 117169 [link] Protein disulfide isomerase (PDI) regulates multiple protein functions by catalyzing the oxidation, reduction, and isomerization of disulfide bonds.

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Vertex ‘ends the year in pain’ as latest non-opioid drug data disappoint

BioPharma Drive: Drug Pricing

Mixed results from a study focused on lower back pain left analysts wanting as well as confused about Vertex's plans to forge ahead in the indication.

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Keypoint Newsletter: December 2024

keypoint

Checkout the December 2024 Keypoint Newsletter for the latest news and views from Keystone Symposia, including Fellows spotlights, our new partership with the Endocrine Society, Women in Science networking events, emerging topics conferences and conference highlights.

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Cold Weather Deaths Keep Rising for Americans

Drugs.com

THURSDAY, Dec. 19, 2024 -- It's a perhaps unexpected consequence of climate change that periods of deep cold now occur more frequently during American winters, despite an overall trend to warmer temperatures year round.That uptick in cold snaps.

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Covalent inhibitors of the RAS binding domain of PI3Ka impair tumor growth driven by RAS and HER2

Covalent Modifiers

Joseph E Klebba, Nilotpal Roy, Steffen M Bernard, Stephanie Grabow, Melissa A. Hoffman, Hui Miao, Junko Tamiya, Jinwei Wang, Cynthia Berry, Antonio Esparza-Oros, Richard Lin, Yongsheng Liu, Marie Pariollaud, Holly Parker, Igor Mochalkin, Sareena Rana, Aaron N. Snead, Eric J. Walton, Taylor E. Wyrick, Erick Aitichson, Karl Bedke, Jacyln C. Brannon, Joel M.

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Ionis gets a milestone approval; Another top FDA official to step down

BioPharma Drive: Drug Pricing

The clearance of Tryngolza gives Ionis its first wholly-owned, marketed medicine. Elsewhere, Robert Temple became the latest FDA leader to leave the agency, and two biotechs cut research deals.

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