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Our DNA is at risk of hacking, warn scientists

Science Daily: Pharmacology News

According to new research next-generation DNA sequencing (NGS) -- the same technology which is powering the development of tailor-made medicines, cancer diagnostics, infectious disease tracking, and gene research -- could become a prime target for hackers.

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New Antibiotic, Blujepa, May Be Effective in Treating Gonorrhea

Drugs.com

TUESDAY, April 15, 2025 — A newly approved antibiotic to treat urinary tract infections may also help fight drug-resistant gonorrhea, a new study shows. The medication, called gepotidacin, sold under the brand name Blujepa, could become the.

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Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation

Covalent Modifiers

Tyler M. McCullough, Vishakha Choudhary, David L. Akey, Meredith A. Skiba, Steffen M. Bernard, Jeffrey D. Kittendorf, Jennifer J. Schmidt, David H. Sherman, and Janet L. Smith ACS Catalysis 2024 14 (16), 12551-12563 DOI: 10.1021/acscatal.4c03637 Emerging antibiotic resistance requires continual improvement in the arsenal of antimicrobial drugs, especially the critical macrolide antibiotics.

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US launches probe that could set stage for pharma tariffs

BioPharma Drive: Drug Pricing

The Commerce Department has begun a so-called Section 232 investigation into the national security effects of the U.S. importing pharmaceuticals and their starting materials.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Fitusiran

New Drug Approvals

Fitusiran 1711.0g/mol, C 78 H 139 N 11 O 30 FDA APPROVED 3/28/2025, Qfitlia , To prevent or reduce the frequency of bleeding episodes in hemophilia A or B Press Release CAS 1499251-18-1 EX-A12034 DA-53206 N-[1,3-Bis[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]-2-[[3-[3-[5-[(2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypentanoylamino]propylamino]-3-oxopropoxy]methyl]propan-2-yl]-12-[(2R,4R)-4

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From boring to bursting: Giant black hole awakens

Science Daily: Pharmacology News

Astronomers are investigating the longest and most energetic bursts of X-rays seen from a newly awakened black hole. Watching this strange behavior unfold in real time offers a unique opportunity to learn more about these powerful events and the mysterious behavior of massive black holes.

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A New UV Light May Help Stop Future Pandemics

Drugs.com

THURSDAY, April 10, 2025 -- Five years after COVID-19 first hit the United States, scientists are already brainstorming how to stop the next big virus.One possible solution? A special kind of ultraviolet light called far-UVC, CBS News.

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FDA plans to phase out animal testing for some drugs

BioPharma Drive: Drug Pricing

The initiative, which will start with monoclonal antibodies, is the first big regulatory shift from the FDA since Martin Makary was sworn in.

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Drafting Effective Drug Patent Applications: Turning Science into Market Power

Drug Patent Watch

"Just spent the morning digging into the world of pharmaceuticals and I'm blown away by the complexities of drafting effective drug patent applications. The team at Drug Patent Watch has done an incredible job of breaking down the key considerations for turning scientific discoveries into market power. From understanding the nuances of patent law to leveraging data-driven strategies, it's clear that the stakes are high in this space.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Covalent Modification of Glutamic Acid Inspired by HaloTag Technology

Covalent Modifiers

Waldmann H, Zhang R, liu J, Gasper R, Janning P. ChemRxiv. 2025 doi:10.26434/chemrxiv-2025-70x40. [link] For targeted covalent protein modification at low reactivity aspartates and glutamates, new methods are in high demand. Inspired by the HaloTag technology we have developed a new technique which employs a reaction between chloroalkane-functionalised ligands and a specific glutamate residue.

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New method for detecting nanoplastics in body fluids

Science Daily: Pharmacology News

Microplastics and the much smaller nanoplastics enter the human body in various ways, for example through food or the air we breathe. A large proportion is excreted, but a certain amount remains in organs, blood and other body fluids. Scientists have now been able to develop a method for detecting and quantifying nanoplastics in transparent body fluids and determining their chemical composition.

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CDC Denies Milwaukee's Request for Help on Lead in Schools

Drugs.com

MONDAY, April 14, 2025 -- When officials in Wisconsin's largest city asked the U.S. Centers for Disease Control and Prevention (CDC) for help dealing with high levels of lead in city schools, the answer wasn't what they expected. The CDC said no.

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Tempest seeks strategic alternatives as cash runs out for Phase 3 trial

BioPharma Drive: Drug Pricing

Amid a funding drought for startups, the company is looking for a deal that can advance its liver cancer drug.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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How to Ensure Compliance in Generic Drug Development

Drug Patent Watch

"Compliance in Generic Drug Development: A Critical Component of Success As the generic drug industry continues to grow, ensuring compliance with regulatory requirements has become a top priority for pharmaceutical companies. At DrugPatentWatch, we've seen firsthand the importance of staying on top of regulatory changes and maintaining a robust compliance program.

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Déjà Vu: OPDP Again Targets Provider Branded Website of Accelerated Approval Drug in Second Untitled Letter of 2025

FDA Law Blog: Biosimilars

By Sarah Wicks & Dara Katcher Levy FDAs Office of Prescription Drug Promotion (OPDP) issued its second Untitled Letter of 2025 to Taiho Oncology (Taiho) for a healthcare provider branded website for its drug LYTGOBI (futibatinib). This letter, dated March 21, 2025, cites Taihos false or misleading representations about the benefits of the drug, which is considered misbranding under the Federal Food, Drug, and Cosmetic Act.

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Popular diabetes medications, including GLP-1 drugs, may protect against Alzheimer's disease

Science Daily: Pharmacology News

Drugs like Ozempic, other blood sugar-reducing medications, may stave off dementia.

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CDC Urges Extra Measles Shot for Some U.S. Travelers Amid Outbreak

Drugs.com

FRIDAY, April 11, 2025 -- The U.S. Centers for Disease Control and Prevention (CDC) now recommends extra measles protection for people traveling to areas with active outbreaks in the United States, CBS News reported.In an April 8 letter, the CDC.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Biotech CEOs, VCs urge Cassidy, Senate to ease impact of FDA cuts

BioPharma Drive: Drug Pricing

Experts say the layoffs are already causing issues in drug development — and things may get far worse without critical institutional knowledge at the FDA.

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FDA Eliminates Animal Testing: Impact on Biotechs

The Premier Consulting Blog

On April 10, 2025, the US FDA announced that it has a long-term plan to eliminate conventional animal testing in drug development, starting with monoclonal antibodies (mAbs).[ 1] Instead, within 3-5 years, the expectation will be to leverage an integrated safety assessment approach, combining information from a comprehensive battery of New Approach Methodologies (NAM).

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Spirulina’s role in shaping the future of preventative biologics

Drug Target Review

The antibiotic market has long faced significant barriers to innovation, with structural issues that make it difficult for new antibiotics to gain traction. As the demand for novel antibiotics remains limited due to the preference for cheaper generics, the market has struggled to incentivise much-needed breakthroughs. This is where Brian Finrows expertise comes in.

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Scientists observe exotic quantum phase once thought impossible

Science Daily: Pharmacology News

A team of researchers reported the first direct observation of a surprising quantum phenomenon predicted over half a century ago known as a superradiant phase transition, which occurs when two groups of quantum particles begin to fluctuate in a coordinated, collective way without any external trigger, forming a new state of matter.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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New Visual Test For Autism Could Aid Earlier Diagnosis

Drugs.com

FRIDAY, April 11, 2025 -- How children respond to movement could provide an early means of detecting autism, a new study says.Children with autism are known to prefer watching repetitive movements over random movements, researchers said.Using.

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New research kindles excitement around stem cell therapies for Parkinson’s

BioPharma Drive: Drug Pricing

Two studies published in Nature found stem cell-derived products can not only be safely transplanted into the brain, but also show promising — albeit unproven — signs of efficacy.

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Let’s Talk Security - Why a Bug Bounty May Be More Valuable Than a Penetration Test

Collaborative Drug

Lets talk security - Why a bug bounty may be more valuable than a penetration test

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Theranostic Strategies: Dual-Function Agents for Imaging and Therapy

Crown Bioscience

Introduction to Theranostics: Bridging Imaging and Therapy The convergence of diagnostics and therapeuticscollectively termed theranosticsis revolutionizing precision medicine. By integrating imaging and therapy within a single platform, theranostics allows for the real-time visualization of disease progression while simultaneously delivering targeted treatment.

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Popular CT scans could account for 5% of all cancer cases a year, study suggests

Science Daily: Pharmacology News

CT scans may account for 5% of all cancers annually, according to a new study that cautions against overusing and overdosing CTs. The danger is greatest for infants, followed by children and adolescents. But adults also are at risk, since they are the most likely to get scans.

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ADHD Drugs Generally Safe For Heart Health, Review Says

Drugs.com

MONDAY, April 14, 2025 -- Worried about taking the ADHD meds youve been prescribed because they might harm your heart health?Theres no need to fret, according to a new evidence review.ADHD medications generally have just a small effect on a per.

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Pharma bosses face down investor angst on tariffs, HHS chaos

BioPharma Drive: Drug Pricing

As first quarter earnings begin, executives are confronting market turmoil, regulatory instability and the threat of U.S. tariffs on their products.

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CDD Vault Update (April 2025): Biphasic Curve Fit, Import Parser Sections, Custom Calculation Functions, Generate Inventory Labels, Inventory Admin Permission

Collaborative Drug

CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:

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