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Syphilis had its roots in the Americas

Science Daily: Pharmacology News

A research team has taken a crucial step towards resolving a long-standing controversy -- was syphilis introduced to Europe from the Americas at the end of the 15th century, or had it been there all along? Ancient pathogen genomes from skeletons that pre-date 1492 confirm its introduction from the Americas, but its world-wide spread remains a grim legacy of the colonial period.

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Study Supports Tamoxifen for DCIS Early Breast Cancers

Drugs.com

MONDAY, Dec. 16, 2024 -- The established hormone therapy drug tamoxifen can significantly decrease the risk of cancer recurring in women with an early, low-risk form of breast cancer, a new study says. Women who took tamoxifen after undergoing a.

Therapies 101
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Sanofi, Teva say study results show gut disease drug could be ‘best in class’

BioPharma Drive: Drug Pricing

Phase 2 results in inflammatory bowel disease hinted the therapy could be more potent than similar medicines from Merck and Roche, each of which were acquired in multibillion-dollar deals.

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The Importance of CDMO Flexibility: Adapting to the Ever-Changing Pharmaceutical Landscape

Drug Patent Watch

Flexibility has become more than just a buzzword it’s a necessity. Contract Development and Manufacturing Organizations (CDMOs) are at the forefront of this shift, playing a crucial role in bringing innovative therapies to market. But what exactly makes flexibility so important for CDMOs, and how can they cultivate this essential trait? Let’s dive into the world of pharmaceutical outsourcing and explore why adaptability is the key to success.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Universal Design for Visual Disabilities in Healthcare – Addressing Complete Blindness – 6

Perficient: Drug Development

Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. Creating an inclusive healthcare environment for individuals with complete blindness is a fundamental aspect of universal design. These individuals rely heavily on non-visual cues to navigate, access information, and communicate effectively.

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Microplastics in the air may be leading to lung and colon cancers

Science Daily: Pharmacology News

Tires and degrading garbage shed tiny pieces of plastic into the air, creating a form of air pollution that researchers suspect may be causing respiratory and other illnesses.

Research 112

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Merck targets 2025 RSV season with antibody now under FDA review

BioPharma Drive: Drug Pricing

An FDA approval of Merck’s drug clesrovimab by June would give physicians another option for protecting newborns from respiratory syncytial virus.

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How AI will reshape pharma by 2025

Drug Target Review

Artificial intelligence (AI) has revolutionised many industries, yet its adoption in pharmaceutical drug development has been notably slower. Concerns surrounding data security, the complexity of AI systems, and the rigorous regulatory frameworks in this field have caused the pharmaceutical industry to approach these technologies with caution. For years, AI and machine learning (ML) were often dismissed as little more than advanced statistics with little practical value in drug development.

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Microbiological Applications: Bacterial Metabolism | BMG LABTECH

BMG Labtech

Bacterial metabolism applications Bacterial metabolism spans the complex interconnected set of chemical reactions that support life in bacteria, ancient single-celled organisms that represent one of the most diverse forms of life on Earth. Bacterial metabolism is the foundation for bacterial growth and is inextricably linked to other organisms in the ecosystem.

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Massive black hole in the early universe spotted taking a 'nap' after overeating

Science Daily: Pharmacology News

Scientists have spotted a massive black hole in the early universe that is 'napping' after stuffing itself with too much food. Like a bear gorging itself on salmon before hibernating for the winter, or a much-needed nap after Christmas dinner, this black hole has overeaten to the point that it is lying dormant in its host galaxy.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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U.S. Woman Living Healthy With Kidney Sourced From Pig

Drugs.com

TUESDAY, Dec. 17, 2024 -- A 53-year-old woman from Alabama has a new lease on life after receiving a gene-edited kidney obtained from a pig, living healthily with the new organ for over a month, her New York City doctors announced Tuesday. Towana.

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Novo’s next-gen obesity drug misses expectations in closely watched trial

BioPharma Drive: Drug Pricing

Novo shares lost nearly a quarter of their value after an experimental combination treatment called cagrisema fell short of the bar set by executives.

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Universal Design for Visual Disabilities in Healthcare – Clear and Accessible Communication – 4

Perficient: Drug Development

Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. Effective communication is vital in healthcare, and ensuring that it is accessible to individuals with visual disabilities is an essential aspect of universal design. Clear and accessible communication methods help patients understand their health information, engage with their care, and make informed decisions.

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A Guide to Adaptive Randomisation in Clinical Trials

Quanticate

A randomised controlled clinical trial is the most prevalent design used in Phase II and Phase III clinical trials, whereby participants are randomly assigned to a control or experimental group with a fixed probability, normally 50% for each treatment. This is the gold standard [1] for identifying the best treatment within the trial with a large degree of certainty [2].

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Origins of lunar water and its connection to Earth's early history

Science Daily: Pharmacology News

Scientists have unveiled groundbreaking research on the origins of lunar water, offering insights that could reshape our understanding of the Earth-Moon system and the broader solar system. The pioneering study explores the isotopic signatures of lunar water, revealing a mix of indigenous and cometary sources.

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Are Microplastics In the Air Putting Your Fertility At Risk?

Drugs.com

WEDNESDAY, Dec. 18, 2024 -- Microscopic plastic particles in the air could be contributing to a wide variety of health problems, including lung and colon cancers.Tires and degrading garbage shed tiny pieces of plastic which become airborne.

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Zepbound, Mounjaro shortages are resolved, FDA confirms

BioPharma Drive: Drug Pricing

The FDA’s decision will close a lucrative market opportunity for compounding pharmacies, although the agency will give a limited grace period before taking any enforcement actions.

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Keypoint Newsletter: Introducing the New Fellows Class of 2025

keypoint

Meet the Keystone Symposia Fellows Class of 2025, a stellar group of post-doctoral fellows and early-career scientists who will take part in this prestigious mentorship program.

Doctors 58
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Oncology advances through the lens of women in STEM

Drug Target Review

Dr Pooja Hingorani, Senior Medical Director of Oncology Early Development at AbbVie , shares her journey in STEM, from her early days in New Delhi to her impactful career in oncology research and drug development. Despite challenges as a woman in the field, Dr Hingorani built a career focused on advancing treatments for pediatric and adult cancers. In this interview, she discusses her path to becoming a physician and clinical researcher, the obstacles she faced, and her dedication to improving o

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Tinkering with the 'clockwork' mechanisms of life

Science Daily: Pharmacology News

Opening new doors for the development of nanotechnologies in medicine and other fields, scientists recreate and compare two natural mechanisms to better program the timescale of molecular communication and functionality.

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Allergies Have You Stuffed Up? Nose Fungi May Be to Blame

Drugs.com

TUESDAY, Dec. 17, 2024 -- There’s fungus among us, and it might be making allergies and asthma worse. People with allergy sniffles and asthma have different fungal colonies in their noses than folks who don’t suffer respiratory.

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Merck calls quits on two immunotherapies for cancer

BioPharma Drive: Drug Pricing

The company is scrapping two drugs aimed at targets called TIGIT and LAG-3, both of which were in the middle of Phase 3 testing.

Drugs 69
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The Real Cost of Complexity: What Every Drug Developer Needs to Know

PPD

Our annual look at the state of the drug development industry highlights a dual set of challenges complicating progress. The drug development industry faces rising costs and increasingly complex protocols as top challenges, with 49% of developers citing costs as their primary concern and 39% pointing to protocol complexity as a key hurdle, according to a recent survey of 150 drug developers worldwide by the PPD clinical research business of Thermo Fisher Scientific.

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Attention Banff Skiers & Riders-- Discount Lift Tickets & Other Winter Activities!

keypoint

Are you interested in skiing, snowboarding, or partaking in other winter activities while attending your meeting in Banff, CA?

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Carnivorous squirrels documented in California

Science Daily: Pharmacology News

California ground squirrels hunt, kill and eat voles, reveals a new study documenting evidence of widespread carnivorous behavior among squirrels.

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Artificial Sweetener Use Tied to Less-Healthy Diets

Drugs.com

WEDNESDAY, Dec. 18, 2024 -- Folks who switch to artificial sweeteners in drinks and food may be drawn to other types of unhealthy fare -- bringing down the quality of their overall diet, new research suggests.The study, published recently in the.

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Merck moves into obesity with deal for Hansoh’s GLP-1 pill

BioPharma Drive: Drug Pricing

News of Merck’s licensing of Hansoh’s preclinical medicine pressured shares in Viking and other obesity drug developers seen as likely buyout targets.

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From Our Stocking to Your Inbox: Happy Holidays!

Alta Sciences

From Our Stocking to Your Inbox: Happy Holidays! blussier Mon, 12/16/2024 - 18:39 HTML 'Tis the season for a little extra joy, and we're thrilled to present "Questions From a Stocking: Holiday Edition!" in which Altascientists fully embrace the holiday spirit as they answer rapid-fire questions pulled from our new favorite stocking. As we share these lighthearted moments, we're filled with deep gratitude for the ideas, discoveries, trials, and successes you've shared with us this year.

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Curves Module Insights

Collaborative Drug

Learn how CDD Vault is utilizing Curves to improve your drug discovery process.

Drugs 52
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Massive volcanic eruptions did not cause the extinction of dinosaurs

Science Daily: Pharmacology News

While volcanism caused a temporary cold period, the effects had already worn off thousands of years before the meteorite, the ultimate cause of the dinosaur extinction event, impacted.

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Team Sports Score Big Points for Your Child's Brain, Study Finds

Drugs.com

TUESDAY, Dec. 17, 2024 -- There may be something special about team sports in childhood that helps sharpen a kids' brain, new research shows. Children who were on soccer or volleyball teams scored higher on tests of "executive function" -- thinking.

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A venture firm breathes new life into an old NGM drug

BioPharma Drive: Drug Pricing

An startup formed by KdT Ventures intends to test the drug, which was once licensed to Merck and evaluated in multiple metabolic disorders, for an unspecified rare conditon.

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Keypoint Newsletter: A Message from Our CEO

keypoint

Keystone Symposia CEO shares his first impressions, improvement and initiatives that will be implemented in 2025.

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