Broad Institute

JANUARY 6, 2025

Researchers devise new way to target and correct disease-related proteins By Leah Eisenstadt January 6, 2025 Breadcrumb Home Researchers devise new way to target and correct disease-related proteins Broad scientists built a diverse library of compounds and found one that stabilizes a dysfunctional protein in Crohns disease, demonstrating their librarys potential to uncover new therapeutic strategies.

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BioPharma Drive: Drug Pricing

JANUARY 7, 2025

Denali’s medicine and a similar one from Calico Life Sciences and AbbVie were not much different than a placebo, bringing the tally of failed drugs in the innovative “Healey platform trial” to seven.

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Science Daily: Pharmacology News

JANUARY 2, 2025

A research team has developed a method for extracting gold from electronics waste, then using the recovered precious metal as a catalyst for converting carbon dioxide (CO2), a greenhouse gas, to organic materials.

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Drugs.com

JANUARY 6, 2025

MONDAY, Jan. 6, 2025 -- Rates of whooping cough in the U.S. continue to climb, according to data from the US Centers for Disease Control (CDC).Over 32,000 cases reported have been reported as of mid-December -- about six times more than there were.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Chemical Biology and Drug Design

JANUARY 5, 2025

5(4-Hydroxyphenyl)-2-(N-Phenyl amino)-1,3,4-Oxadiazole (Hppo) can considered as a versatile agent in designing novel pharmaceuticals. ABSTRACT Oxadiazole compounds are of great interest because they have a range of biological activities ranging from antioxidants to anticancer agents. Against this background, we wanted to demonstrate the antioxidant, enzyme inhibitory, and anticancer effects of 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole (Hppo).

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Broad Institute

JANUARY 6, 2025

Feng Zhang awarded the National Medal of Technology and Innovation By Corie Lok January 6, 2025 Breadcrumb Home Feng Zhang awarded the National Medal of Technology and Innovation Zhang and 22 other individuals received the USs highest honors for science and technology. By Broad Communications January 6, 2025 Credit: Ryan K. Morris Feng Zhang receives the National Medal of Technology and Innovation at the White House from Arati Prabhakar (left), director of the White House Office of Science and T

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BioPharma Drive: Drug Pricing

JANUARY 8, 2025

The regulator is requiring labeling that warns of Guillan-Barré syndrome, although it said data don’t prove a causal link and affirmed the shots’ benefit outweighs their risks.

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Drugs.com

JANUARY 3, 2025

FRIDAY, Jan. 3, 2025 -- If you've picked up a bag of Marketside Broccoli Florets from Walmart recently, check your fridge or freezer. The company has issued a recall of the 12-ounce bags in 20 states after testing uncovered listeria bacteria in one.

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Codon

JANUARY 5, 2025

Today we launch Issue 05 of Asimov Press. Read our full Editors’ Note and preview upcoming articles on our website. Thanks for reading! Edwin Cohn, a temperamental and entrepreneurial protein chemist working at Harvard University in the early 1900s, is perhaps one of the most underrated translational scientists of all time. In 1940, with the likelihood of America’s involvement in World War II steadily rising, the U.S. military approached Cohn about developing medical products from bl

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Broad Institute

JANUARY 9, 2025

Scientists engineer CRISPR enzymes that evade the immune system By Allessandra DiCorato January 9, 2025 Breadcrumb Home Scientists engineer CRISPR enzymes that evade the immune system The new genome-editing tools could lead to safer, more efficient gene therapies. By Allessandra DiCorato January 9, 2025 Credit: Natalie Velez, Broad Communications Related news Researchers uncover new CRISPR-like system in animals that can edit the human genome The core components of CRISPR-based genome-editing th

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

JANUARY 3, 2025

Scientists recently discovered that the giant 'conveyer belt' currents that push star-forged material out of our galaxy and pull it back in can also transport carbon atoms. That means that a good deal of the carbon here on Earth, including the carbon in our bodies, likely left the galaxy at some point!

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BioPharma Drive: Drug Pricing

JANUARY 6, 2025

The startup is developing a kind of macrocyles, which share strengths of both small molecules and biologics, as oral medicines against “validated blockbuster biologic targets.

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Small Molecule 120

Drugs.com

JANUARY 2, 2025

THURSDAY, Jan. 2, 2024 -- Weight loss tops many folks list of New Years resolutions, and lots of people are turning to cutting-edge weight-loss drugs like Ozempic to help them drop excess pounds.These drugs, called glucagon-like peptide-1 receptor.

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Plenge Gen

JANUARY 7, 2025

When I last wrote about AI on this blog three years ago, I spoke of it being a tool with the potential to transform scientific discovery, but the application I described was primarily theoretical. For AI to be a meaningful tool in R&D, I argued, we needed better sources of truth better data sets that AI tools could query and learn from over time and technology capable of integrating multiples steps into a semi-automated system.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Perficient: Drug Development

JANUARY 6, 2025

Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. The healthcare sector is witnessing an evolutionary shift towards inclusivity and accessibility. At the heart of this transformation lies universal designa principle that advocates for the creation of environments and products to be usable by all people, to the greatest extent possible, without the need for adaptation or specialized design.

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Science Daily: Pharmacology News

JANUARY 3, 2025

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.

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BioPharma Drive: Drug Pricing

JANUARY 8, 2025

Alongside plans to spin out a new company, the Belgian drugmaker said it will cut some 300 positions, or about 40% of its current workforce.

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Research 113

Drugs.com

JANUARY 8, 2025

WEDNESDAY, Jan. 8, 2024 -- The antiviral pill Paxlovid might help some patients who are suffering from long COVID.A five-day course of Paxlovid is known to help limit symptoms and shorten illness in patients during an initial bout of COVID-19.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Crown Bioscience

JANUARY 8, 2025

How To Choose and Use Drug Resistance Models Drug resistance remains one of the most pressing challenges in cancer drug development, as 90% of cancer deaths worldwide can be attributed to resistance and the drug ineffectiveness associated with it. This ongoing issue can take one of two forms: intrinsic resistance, where cancer cells show inherent insensitivity to therapies from the outset, and required resistance, which develops during treatment as cancer cells adapt and evolve to survive exposu

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Covalent Modifiers

JANUARY 7, 2025

Tomonori Tamura and Itaru Hamachi Accounts of Chemical Research 2025 58 (1), 87-100 DOI: 10.1021/acs.accounts.4c00628 Selective chemical modification of endogenous proteins in living systems with synthetic small molecular probes is a central challenge in chemical biology. Such modification has a variety of applications important for biological and pharmaceutical research, including protein visualization, protein functionalization, proteome-wide profiling of enzyme activity, and irreversible inhi

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Targeted Protein Degradation Pharmaceuticals Research Treatment 59

Science Daily: Pharmacology News

JANUARY 2, 2025

Viral infections may play a role in Alzheimer's disease.

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BioPharma Drive: Drug Pricing

JANUARY 2, 2025

Expected readouts in diabetes, cancer and depression headline a series of study results that could help the biotechnology sector regain its footing after a shaky year.

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Clinical Trials Trials 108

Drugs.com

JANUARY 2, 2025

THURSDAY, Jan. 2, 2025 -- Considering a New Year’s resolution to quit smoking? New research might provide all the motivation you need: Each cigarette could shorten your life by up to 22 minutes, researchers say. The findings, published Dec.

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Drug Patent Watch

JANUARY 9, 2025

Navigating the complex landscape of drug development and manufacturing can be a daunting task. Enter the Contract Development and Manufacturing Organization (CDMO) a lifeline for many startups looking to bring their innovative therapies to market. But how do you, as a startup, ensure you’re making the most of this crucial partnership? Let’s dive into the best CDMO practices that can set your startup on the path to success.

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Fierce BioTech

JANUARY 3, 2025

Optimizing Formulation Strategies for Poorly Soluble Compounds: Insights into Bioavailability Enhancement and Accelerated Development dwunderlin Fri, 01/03/2025 - 15:54 Wed, 02/19/2025 - 11:00 Resource Type Webinar Feng Zhang, Ph.D. Hong Li, Ph.D. Duration 60 Minutes With 70% of small molecule drug candidates classified as poorly soluble (BCS Class II and IV), achieving adequate absorption in the gastrointestinal (GI) tract remains a critical challenge in drug development.

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Science Daily: Pharmacology News

JANUARY 6, 2025

Tuberculosis (TB) is the world's biggest infectious disease killer with multidrug-resistant TB (MDR-TB) posing a particular threat to global health. A study shows that resistance to the new MDR-TB treatment regimen recently recommended by the World Health Organization is already spreading between patients.

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BioPharma Drive: Drug Pricing

JANUARY 7, 2025

The startup, which has already raised more than half a billion dollars, released Phase 2 results that could position its drug as a future threat to weight loss medicines from Novo Nordisk and Eli Lilly.

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Drugs.com

JANUARY 8, 2025

WEDNESDAY, Jan. 8, 2025 -- Three GLP-1 drugs are best at helping obese and overweight people drop weight, including one that hasnt yet been approved for that purpose.A new evidence review published in the Annals of Internal Medicine shows that the.

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Crucial Data Solutions

JANUARY 8, 2025

RENO, NV, UNITED STATES, January 8, 2025 /EINPresswire.com/ — Crucial Data Solutions (CDS), a leader in eClinical technology and a. The post Crucial Data Solutions Begins 2025 with AI Breakthroughs and Leadership Momentum appeared first on Crucial Data Solutions.

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Fierce BioTech

JANUARY 3, 2025

Innovations in aseptic processing for container closure systems dwunderlin Fri, 01/03/2025 - 14:26 Wed, 02/12/2025 - 10:00 Resource Type Webinar Jim Thompson Julian Petersen Duration 60 Minutes The pharmaceutical landscape is shifting from blockbuster drugs to personalized treatments, driving the need for innovative container closure systems. This joint webinar presentation by West and Groninger, explores the unique challenges of Cell and Gene Therapies, mRNA LNP therapeutics particularly regard

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Science Daily: Pharmacology News

JANUARY 3, 2025

Antibodies that bind to a previously untargeted portion of the malaria parasite could lead to new monoclonal antibody treatments and vaccines for malaria.

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BioPharma Drive: Drug Pricing

JANUARY 7, 2025

Results from a study called Mariposa found a regimen of Rybrevant and Lazcluze helped patients with a common form of advanced lung cancer live longer.

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Drugs 80

Drugs.com

JANUARY 7, 2025

TUESDAY, Jan. 7, 2025 -- The U.S. Food and Drug Association (FDA) released the first-ever guidelines for levels of lead in processed baby foods this week. However, many health and safety advocates say they are not satisfied with the guidance.Under.

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