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Researchers have announced the creation of the first operating system designed for quantum networks: QNodeOS. The research marks a major step forward in transforming quantum networking from a theoretical concept to a practical technology that could revolutionize the future of the internet.
The joint venture with generative AI firm Hologen hands MeiraGTx $200 million up front as well as other financial perks — a “transformative” deal, according to the company’s CEO.
FRIDAY, March 14, 2025 -- Only 43 percent of parents report they are able to find accurate and current information on avian influenza A(H5N1), commonly known as bird flu, according to the University of Michigan Health C.S. Mott Children's Hospital.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Antonia C. Darragh, Andrew M. Hanna, Justin H. Lipner, Alastair J. King, Nicole B. Servant, and Mirza Jahic ACS Pharmacol. Transl. Sci. 2025 [link] Uncovering a drugs mechanism of action and possible adverse effects are critical components in drug discovery and development. Moreover, it provides evidence for why some drugs prove more effective than others and how to design better drugs altogether.
Fragment-based drug discovery (FBDD) was applied to cytochrome P450 3A4 reconstituted in Nanodiscs (NDs) with various lipid compositions. The choice of ND lipid influenced drug membrane interactions and fragment hit rates, demonstrating the critical role of the membrane environment in fragment screening for membrane proteins. ABSTRACT Membrane proteins (MPs) are important yet challenging targets for drug discovery.
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Fragment-based drug discovery (FBDD) was applied to cytochrome P450 3A4 reconstituted in Nanodiscs (NDs) with various lipid compositions. The choice of ND lipid influenced drug membrane interactions and fragment hit rates, demonstrating the critical role of the membrane environment in fragment screening for membrane proteins. ABSTRACT Membrane proteins (MPs) are important yet challenging targets for drug discovery.
Researchers were shocked to see that bacteria's antimicrobial resistance is strengthened when exposed to plastic particles and point to a potential outsized impact on refugees.
TUESDAY, March 11, 2025 -- The National Institutes of Health (NIH) is cutting or canceling more than 40 grants focused on vaccine hesitancy and ways to increase vaccine acceptance, according to an email obtained by The Washington Post.The message .
New technology puts a spatial lens on CRISPR screening By Leah Eisenstadt March 12, 2025 Breadcrumb Home New technology puts a spatial lens on CRISPR screening Perturb-FISH reveals impacts of perturbations on gene expression and phenotype with single-cell, spatial resolution, allowing study of effects within and between cells. By Leah Eisenstadt March 12, 2025 Credit: Broad Communications Scientists in the Spatial Technology Platform at the Broad develop, use, and share spatial -omics approaches
Design and synthesis of pyrrole-tethered bisbenzoxazole (PTB) derivatives reveal potent anticancer activity against MCF-7 breast cancer cells. Compounds B8 , B14 , and B18 exhibit ~20-fold lower IC 50 values than tamoxifen, induce early-stage apoptosis, and arrest the cell cycle at the G1 phase via caspase-9 activation. These findings position PTB derivatives as promising candidates for targeted breast cancer therapy.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
New research has revealed that people often do not perceive the true meaning of their pet's emotions and can misread their dog. The reasons for this are many and include a human misunderstanding of dog expressions due to a bias towards projecting human emotions onto our pets.
WEDNESDAY, March 12, 2025 -- Only 17 percent of adults say they want to see Medicaid funding decreased, while 42 percent think funding should increase and 40 percent think it should be kept about the same, according to results of the February 2025.
Sygnature Discovery offers high throughput screening along with additional hit identification tools including virtual screening, knowledge-based design, and fragment screening. Employing a comprehensive strategy for hit identification, we use the most effective methods to accurately pinpoint hit series that have the highest potential for evolving into compounds with drug-like properties.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
We have discovered a novel non-covalent MurA inhibitor as an antibacterial agent through machine learning and bioactivity testing. This is the first to use machine learning for virtual screening of non-covalent inhibitors of MurA. ABSTRACT The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis.
Astronomers have revealed new evidence that there are not just one but four tiny planets circling around Barnard's Star, the second-nearest star system to Earth.
MONDAY, March 10, 2025 -- A common vaginal infection that affects nearly 1 in 3 women worldwide should be reclassified as a sexually transmitted infection (STI), a new study suggests.Bacterial vaginosis (BV) is now treated as a womens health i.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
The 2025 CDD Basel Science Community Meeting brought together researchers, industry experts, and thought leaders to discuss advancements in drug discovery, data management, FAIR data principles, and AI in research.
Intro In this post, we’ll take a look at a couple Sitecore SDKs commonly used to build XM Cloud head applications. Specifically, we’ll be looking at how to disable cookies used by these SDKs. This can be useful for data privacy and/or regulatory compliance reasons. These SDKs allow your application to integrate with other composable Sitecore services like analytics, personalization, and search.
Researchers have conducted a study that scours 'the vast and often contradictory literature on the carcinogenicity of red and white wine' to assess whether this assumption holds up, and to compare the cancer risks associated with wine type.
THURSDAY, March 13, 2025 -- After new U.S. Food and Drug Administration testing of acne products containing benzoyl peroxide, the agency determined that a small number of products should be recalled for possible benzene contamination, the FDA.
The Biosimilar Revolution: How It's Changing the Game for Biologic Drug Manufacturers As the pharmaceutical industry continues to evolve, one trend is gaining significant attention: the rise of biosimilars. For those who may be new to this concept, biosimilars are biologic drugs that are highly similar to existing biologic medicines, but at a lower cost.
Perficient’s talented colleagues from around the world bring unique perspectives that spark innovation and shatter boundaries. By fostering a culture that champions growth and celebrates every individual, were forging deep, meaningful connections that drive our success. Meet Joe Tufo, lead technical consultant, whose unwavering dedication to mentoring has promoted greater collaboration across Perficients Sitecore practice.
The agency formulated its advice to manufacturers after coordinating with the CDC and Defense Department. An advisory meeting that's typically held was canceled last month.
The 2025 U. S. State of the Birds Report, produced by a coalition of leading science and conservation organizations, reveals continued widespread declines in American bird populations across all mainland and marine habitats, with 229 species requiring urgent conservation action.
WEDNESDAY, March 12, 2025 -- The number of children poisoned through exposure to fentanyl, a powerful synthetic opioid, has skyrocketed in recent years, researchers have reported.Fentanyl poisonings increased by 924% among children 12 and younger.
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