Covalent Modifiers
APRIL 12, 2025
Pasquale A. Morese, Ayaz Ahmad, Mathew P. Martin, Richard A. Noble, Sara Pintar, Lan Z. Wang, Shangze Xu, Andrew Lister, Richard A. Ward, Agnieszka K. Bronowska, Martin E. M. Noble, Hannah L. Stewart & Michael J. Waring Commun Chem 8 , 111 (2025). [link] The discovery of targeted covalent inhibitors is of increasing importance in drug discovery.
Science Daily: Pharmacology News
APRIL 9, 2025
Heavy drinkers who have eight or more alcoholic drinks per week have an increased risk of brain lesions called hyaline arteriolosclerosis, signs of brain injury that are associated with memory and thinking problems, according to a new study.
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Science Daily: Pharmacology News
APRIL 7, 2025
What if we spend decades building advanced telescopes to search for life on other planets and come up emptyhanded? A recent study exploring what we can learn about life in the universe -- even if we don't detect signs of life or habitability. Using advanced statistical modeling, the research team sought to explore how many exoplanets scientists should observe and understand before declaring that life beyond Earth is either common or rare.
Drugs.com
APRIL 10, 2025
THURSDAY, April 10, 2025 -- Five years after COVID-19 first hit the United States, scientists are already brainstorming how to stop the next big virus.One possible solution? A special kind of ultraviolet light called far-UVC, CBS News.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
BioPharma Drive: Drug Pricing
APRIL 7, 2025
HELP committee chair Bill Cassidy, R-La., had invited Kennedy to testify April 10 on the sweeping layoffs of federal health workers Kennedy ordered last month. A hearing could still take place later.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Covalent Modifiers
APRIL 9, 2025
Dennis H. Kim and Watson J. Lees Biochemistry 2025 DOI: 10.1021/acs.biochem.4c00522 The antibiotic fosfomycin is an epoxy-phosphonate natural product with a broad spectrum of antibacterial activity and distinct mechanism of action that has been in clinical use for 50 years. Fosfomycin is an irreversible covalent inhibitor of UDP-GlcNAc enolpyruvyl transferase (MurA), which catalyzes the first committed step in bacterial peptidoglycan biosynthesis.
Drugs.com
APRIL 11, 2025
FRIDAY, April 11, 2025 -- The U.S. Centers for Disease Control and Prevention (CDC) now recommends extra measles protection for people traveling to areas with active outbreaks in the United States, CBS News reported.In an April 8 letter, the CDC.
BioPharma Drive: Drug Pricing
APRIL 8, 2025
“There will be a ChatGPT moment for biotechnology,” a bipartisan commission wrote in the new report, which calls for the U.S. to invest at least $15 billion into the sector over the next five years.
Drug Patent Watch
APRIL 10, 2025
"Just spent the morning digging into the world of pharmaceuticals and I'm blown away by the complexities of drafting effective drug patent applications. The team at Drug Patent Watch has done an incredible job of breaking down the key considerations for turning scientific discoveries into market power. From understanding the nuances of patent law to leveraging data-driven strategies, it's clear that the stakes are high in this space.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
APRIL 7, 2025
A web platform uses a chatbot to enable any chemist -- including undergraduate chemistry majors -- to configure and execute complex quantum mechanical simulations through chatting.
Drug Target Review
APRIL 7, 2025
As our understanding of the underlying biology of disease grows more sophisticated, emerging therapies operate on increasingly complex biopathological systems and mechanisms. Advanced strategies and tools are being implemented to establish the safety and efficacy of new therapeutic modalities, with the development of new biomarkers becoming one of the most relevant approaches for enhancing the precision and utility of early-stage studies.
Drugs.com
APRIL 7, 2025
MONDAY, April 7, 2025 -- Some recent cuts at U.S. government health agencies may be reversed, including a key program that tracks lead exposure in children, U.S. Health and Human Services Secretary Robert F. Kennedy Jr. said last week.The lead.
BioPharma Drive: Drug Pricing
APRIL 11, 2025
The initiative, which will start with monoclonal antibodies, is the first big regulatory shift from the FDA since Martin Makary was sworn in.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Perficient: Drug Development
APRIL 7, 2025
Metadata contention in Unity Catalog can occur in high-throughput Databricks environments, slowing down user queries and impacting performance across the platform. Our Finops strategy shifts left on performance. However, we have found scenarios where clients are still experiencing query slowdowns intermittently and even on optimized queries. As our client’s lakehouse footprint grows, we are seeing an emerging pattern where stress on Unity Catalog can have a downstream drag on performance a
Science Daily: Pharmacology News
APRIL 9, 2025
Evidence shows that hunter-gatherers were crossing at least 100 kilometers (km) of open water to reach the Mediterranean island of Malta 8,500 years ago, a thousand years before the arrival of the first farmers.
Covalent Modifiers
APRIL 7, 2025
Meehan, M.; Scofield, G.; Stahl, C.; Wolfe, J.; Horne, W. S.; Liu, P.; Brummond, K. ChemRxiv 2025. [link] Herein, we present a systematic study on the effects of electronically diverse heteroarenes on the rate of glutathione (GSH) addition to novel N-heteroaryl methylene-lactam covalent reactive groups (CRGs). Despite their unique electronic and drug-like properties, heteroarenes have not been extensively studied as handles for systematically tuning the reactivity of CRGs.
Drugs.com
APRIL 8, 2025
TUESDAY, April 8, 2025 -- The U.S. Senate has confirmed the appointment of Mehmet Oz, M.D., to head the Centers for Medicare & Medicaid Services (CMS), according to a report from The New York Times.The TV celebrity doctor and cardiothoracic.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
APRIL 10, 2025
Experts say the layoffs are already causing issues in drug development — and things may get far worse without critical institutional knowledge at the FDA.
Drug Target Review
APRIL 7, 2025
The challenge of GPCR drug discovery G protein-coupled receptors (GPCRs) are one of the most desirable and challenging target classes in drug discovery, as their mutation can lead to a wide range of diseases such as cancer, cardiovascular disorders and neurological conditions. GPCRs are a large family of cell surface receptors that play a key role in transmitting signals from the outside of a cell to its interior.
Science Daily: Pharmacology News
APRIL 7, 2025
Researchers have successfully demonstrated the UK's first long-distance ultra-secure transfer of data over a quantum communications network, including the UK's first long-distance quantum-secured video call.
Collaborative Drug
APRIL 8, 2025
Drug Discovery Industry Roundup with Barry Bunin April 8th, 2025
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
APRIL 11, 2025
FRIDAY, April 11, 2025 -- How children respond to movement could provide an early means of detecting autism, a new study says.Children with autism are known to prefer watching repetitive movements over random movements, researchers said.Using.
BioPharma Drive: Drug Pricing
APRIL 7, 2025
“We, like so many others, have been forced to take steps to extend our cash runway,” said Tango’s CEO, citing the “extremely challenging financial markets.
FDA Law Blog: Biosimilars
APRIL 7, 2025
Come together with leaders from the pharmaceutical, biotechnology, and diagnostic industries to unpack huge changes at the American Conference Institutes 23rd Advanced Summit on Life Sciences Patents , which is scheduled to take place from May 19-20, 2025 at the New York Bar Association in New York, NY. In a year of major change and outstanding questions, growing scrutiny on patent protection and drug pricing, and uncertainty around global price control measures and the Inflation Reduction Act,
Science Daily: Pharmacology News
APRIL 9, 2025
In a cave overlooking the ocean on the southern coast of South Africa, archaeologists discovered thousands of stone tools, created by ancient humans roughly 20,000 years ago. By examining tiny details in the chipped edges of the blades and stones, archaeologists are able to tell how the tools were made -- which revealed that people were sharing crafting techniques over wide distances.
Fierce BioTech
APRIL 7, 2025
Why speed and clinical accuracy of information and data is critical for physicians Learn how speed and accuracy of clinical information is transforming healthcare delivery and how your brand can become part of these high-value clinical conversations at the point of decision-making. Download now. sdees Mon, 04/07/2025 - 10:57 Learn how speed and accuracy of clinical information is transforming healthcare delivery and how your brand can become part of these high-value clinical conversations at the
Drugs.com
APRIL 9, 2025
WEDNESDAY, April 9, 2025 -- An experimental drug can help patients with advanced multiple sclerosis (MS) delay the progressive disability that comes with their disorder, a new clinical trial suggests.The drug, tolebrutinib, delayed disability.
BioPharma Drive: Drug Pricing
APRIL 7, 2025
The pharma giant is wagering potentially billions of dollars on technology from ABL Bio that’s designed to get drugs across the blood-brain barrier.
Collaborative Drug
APRIL 10, 2025
CDD Update March #2 2025 Full Atom Layout of Macromolecules New Dataset for AI Similarity Searching Import Inventory Locations by Unique Box Names:
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