Drug Discovery World

SEPTEMBER 12, 2024

New research has shown that Ellorarxine, a novel drug compound developed by biotech Nevrargenics, provides a robust neuroprotective effect and reduces neuronal death in cell models of neurodegenerative disease. The peer reviewed study published in Frontiers in Neuroscience was conducted by academics at Aberdeen and Durham Universities in the UK. Based on the results, the company has secured approval from the Medicines and Healthcare products Regulatory Agency (MHRA) to run a human study in the

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BioPharma Drive: Drug Pricing

SEPTEMBER 12, 2024

The offerings by Bicara, Zenas and MBX give a glimpse into what industry insiders describe as a backlog of mature startups waiting for the right opportunity to test public markets.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Researchers have created microscale robots less than 1 millimeter in size that are printed as a 2D hexagonal 'metasheet' but, with a jolt of electricity, morph into preprogrammed 3D shapes and crawl.

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Drugs.com

SEPTEMBER 12, 2024

THURSDAY, Sept. 12, 2024 -- It could be a real breakthrough for people at risk for HIV infection: A shot given every six months that reduces their risk by a whopping 96%.That's according to new trial results released Thursday by Gilead Sciences.

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Clinical Trials

Drug Patent Watch

SEPTEMBER 12, 2024

In the labyrinthine world of pharmaceuticals, where the cost of life-saving medications can often feel like a roll of the dice, the FDA is implementing a strategy that aims to bring some much-needed transparency and affordability to the market. This strategy, known as the ‘Rule of Three,’ is a game-changer in the battle against soaring drug prices.

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Drug Discovery World

SEPTEMBER 12, 2024

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Dr Friso Postma, Vice President of AI Drug Discovery at BioXcel Therapeutics. Thanks to BioXcel’s AI platform, the company was able to repurpose previous drugs to obtain FDA approval for its acute treatment for agitation associated with schizophr

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Science Daily: Pharmacology News

SEPTEMBER 9, 2024

Scientists have developed a new AI algorithm that can separate brain patterns related to a particular behavior. This work promises to improve brain-computer interfaces and aid with the discovery of new brain patterns.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- Widespread and easy access to guns is the reason behind the shockingly high rate of firearm deaths in the United States, and not any rise in mental health problems suffered by perpetrators, a new study shows.The United.

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Quanticate

SEPTEMBER 13, 2024

With the implementation of technology rapidly increasing, stricter regulatory standards, and growing demand for innovative treatments, the trends within the industry continue to evolve, impacting the future of clinical trials both positively and negatively. In our article, we cover the key trends that have been shaping clinical trials so far in 2024, and those that are predicted to continue into 2025.

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Drug Discovery World

SEPTEMBER 13, 2024

News round-up for 9-13 September by DDW Senior Digital Content Editor Diana Spencer. This week, DDW has opened registrations for its webinar ‘ The latest advancements driving neuroscience drug discovery research ’, so our news highlights focus on developments in neuroscience, including a novel drug that has been shown to reduce neuronal death, and a potential disease-modifying treatment for dementia.

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Clinical Trials

Collaborative Drug

SEPTEMBER 11, 2024

Chemical Safety Information: When working in a lab, you must understand the risks associated with handling chemicals. CDD Vault now displays safety information obtained from PubChem as a helpful reminder. If available, you will find hazard pictograms next to the name at the top of the molecule page.

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Science Daily: Pharmacology News

SEPTEMBER 12, 2024

A landslide in a remote part of Greenland caused a 200 meter (650 foot) mega-tsunami that sloshed back and forth across a fjord for nine days, generating vibrations throughout Earth, according to a new study. The study concluded that this movement of water was the cause of a mysterious, global seismic signal that lasted for nine days and puzzled seismologists in September 2023.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- The weight-loss drug liraglutide helped obese children lower their BMI and reach a healthier weight, researchers report.The findings, published Tuesday in the New England Journal of Medicine and presented.

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FDA Law Blog: Biosimilars

SEPTEMBER 11, 2024

By John W.M. Claud — Last week, FDA revised one of its two guidances relating to nitrosamines, Control of Nitrosamine Impurities in Human Drugs. Nitrosamines are impurities that can form during drug manufacturing and are considered potentially potent carcinogens. One specific kind of nitrosamines called N-nitrosamine drug substance-related impurities, or NDSRIs, are especially vexing to FDA and to industry because they mimic the structure of the specific active pharmaceutical ingredients (API),

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Clinical Trials

Drug Discovery World

SEPTEMBER 13, 2024

QL Biopharm, a clinical stage biopharmaceutical company developing biologic drugs for the treatment of metabolic diseases, has shared Phase Ic clinical data for its lead drug candidate ZT002. The data was presented at the European Association for the Study of Diabetes (EASD) Annual Meeting 2024, Madrid, Spain. The presentation was titled ‘ZT002, a novel ultra long-acting GLP-1 receptor agonist in adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose Phase I

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Perficient: Drug Development

SEPTEMBER 9, 2024

Sitecore Content Hub is a world-class platform for centralizing and managing content across various channels. It helps businesses organize and streamline often chaotic, messy content operations. It does this by providing an architecture or schema for content and its interconnections. A schema defines how different types of assets are structured, organized, related to each other.

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Science Daily: Pharmacology News

SEPTEMBER 10, 2024

Methane concentrations in Earth's atmosphere increased at record speed over the past five years. At least two-thirds of annual methane emissions now come from human activities, including fossil fuel use, agriculture, and landfills and other waste.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- As fears of the consequences of an unintended pregnancy rose after Roe v. Wade was overturned in 2022, rates of surgical sterilization rose in those states most affected by the decision, new research shows. Rates of.

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Drug Patent Watch

SEPTEMBER 11, 2024

The pharmaceutical industry has witnessed significant advancements in recent years, particularly in the realm of nanotechnology. This innovative field has revolutionized the way drugs are developed, manufactured, and delivered to patients.

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Drug Discovery World

SEPTEMBER 13, 2024

A Dupixent (dupilumab) pivotal study (ADEPT) in bullous pemphigoid (BP) has met the primary and all key secondary endpoints evaluating its investigational use in adults with moderate-to-severe disease. In the study, five times more Dupixent patients achieved sustained disease remission compared to those on placebo. Sustained disease remission was defined as complete clinical remission with completion of oral corticosteroids (OCS) taper by week 16 without relapse and no rescue therapy use during

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keypoint

SEPTEMBER 11, 2024

By Shannon Weiman In 2023 we launched a new initiative to add health equity programming to select meetings to raise awareness for health disparities in various fields and initiate discussions on how to rectify these health inequities through scientific research and discovery. These messages are of critical importance to the global research community, so we are releasing the audio recordings of these Health Equity Forums open access, to inform broader audiences about these issues and inspire them

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Science Daily: Pharmacology News

SEPTEMBER 9, 2024

Out-of-body experiences, such as near-death experiences, can have a 'transformative' effect on people's ability to experience empathy and connect with others, new research explains.

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Drugs.com

SEPTEMBER 12, 2024

THURSDAY, Sept. 12, 2024 -- Prescriptions for amphetamine stimulants to treat ADHD have increased significantly in recent years, particularly during the pandemic.Unfortunately, high doses of stimulants like Adderall can increase the risk of.

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Covalent Modifiers

SEPTEMBER 14, 2024

Dong, S., Huang, H., Li, J. et al. Commun Chem 7 , 201 (2024). [link] Multi-functional cysteine-targeting covalent warheads possess significant therapeutic potential in medicinal chemistry and chemical biology. Herein, we present novel unsaturated and asymmetric ketone (oxazolinosene) scaffolds that selectively conjugate cysteine residues of peptides and bovine serum albumin under normal physiological conditions.

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Drug Discovery World

SEPTEMBER 13, 2024

Oxford Nanopore Technologies has joined the PROGRESS study to support improved outcomes for childhood leukaemias in Ghana. The consortium so far includes Yemaachi Biotech, Pediatric Oncology Units at Korle Bu Teaching Hospital, Komfo Anokye Teaching Hospital and Greater Accra Regional Hospital, and institutions like Newcastle University, UK. It aims to leverage world-class expertise and technology to address the pressing issue of childhood cancer in Africa, with a view to setting a new standard

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keypoint

SEPTEMBER 11, 2024

In June we wrapped up our 2024 conference season, aligning with the academic calendar. Altogether we hosted 52 conferences across North America, Europe and Asia, serving nearly 9,000 participants and providing financial aid to over 500 students, post-docs, underrepresented scientists and scientists from low- and middle-income countries. Find out more about our attendees below and see what they are saying about Keystone Symposia!

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

It's a dogma taught in every introductory biology class: Proteins are composed of combinations of 20 different amino acids, arranged into diverse sequences like words. But researchers trying to engineer biologic molecules with new functions have long felt limited by those 20 basic building blocks and strived to develop ways of putting new building blocks -- called non-canonical amino acids -- into their proteins.

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Drugs.com

SEPTEMBER 12, 2024

THURSDAY, Sept. 12, 2024 -- The injectable weight-loss drug Zepbound appears to work better in women than in men, according to a new analysis of the clinical trials that led to its approval.All doses of tirzepatide consistently reduced weight in.

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FDA Law Blog: Biosimilars

SEPTEMBER 15, 2024

By Kurt R. Karst — “Inter Partes Review” and “Section 101” are not terms you typically run into on this all-things-FDA blog, but we have talked about such patent-related issues before ( here and here ), and they are important legal (patent) principles, particularly in the context of drug and biological products (and the Hatch-Waxman Amendments and the Biologics Price Competition and Innovation Act (“BPCIA”)).

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Drug Discovery World

SEPTEMBER 12, 2024

Glasgow, UK-based ILC Therapeutics has successfully completed a fundraise of £2.5 ($3.2) million. The company develops hybrid interferons, a new drug class engineered for improved therapeutic profiles across multiple indications. The money will support the continued pre-clinical development of the company’s two lead assets, Alfacyte and Dermacyte, as they move towards the clinic.

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keypoint

SEPTEMBER 11, 2024

Checkout Health Equity highlights, climate & sustainability conferences, emerging topics & more from Keystone Symposia in our September 2024 Keypoint Newsletter.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Since their invention in the 1920s, jungle gyms and monkey bars have become both fixtures of playgrounds and symbols of childhood injury that anxious caretakers want removed. Anthropologists mark 100 years of the iconic playground equipment by arguing that risky play exercises a biological need passed on from apes and early humans for children to independently test and expand their physical and cognitive abilities in a context in which injury is possible but avoidable.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- Contrary to a warning placed on labels for CART-T cancer therapies, use of these treatments does not appear to boost the odds for a secondary cancer later, a new study shows.Researchers at Memorial Sloan Kettering.

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addgene Blog

SEPTEMBER 12, 2024

If you’re using antibodies in your research, you've probably found yourself staring at a browser full of tabs, each open to a different antibody option. Or you may find yourself with only two options, but very little data on which might work in your application. It can be quite difficult to decide on which antibody to request for your experiment!

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