Drug Discovery World

SEPTEMBER 4, 2024

The European Commission has granted orphan medicinal product designation (OMPD) to Cereno Scientific’s lead drug candidate CS1 for pulmonary arterial hypertension (PAH). CS1 is an HDAC inhibitor that works through epigenetic modulation, being developed to offer improved quality of life and prolonged life for patients with PAH. Companies that obtain orphan designation benefit from protocol assistance, a type of scientific advice specific for designated orphan drugs, and market exclusivity once th

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Drugs.com

SEPTEMBER 6, 2024

FRIDAY, Sept. 6, 2024 -- Saltwater nose drops can reduce the length of a kid’s cold by two days, a new study demonstrates.“We found that children using saltwater nose drops had cold symptoms for an average of six days, where those with usual care ha.

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BioPharma Drive: Drug Pricing

SEPTEMBER 4, 2024

Over the past 10 years, PD1-blocking medicines have transformed cancer care. But the steady expansion of their use has slowed and, despite much trying, pharmaceutical companies have largely failed to top the drugs’ successes.

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Science Daily: Pharmacology News

SEPTEMBER 4, 2024

In creating a pair of new robots, researchers cultivated an unlikely component, one found on the forest floor: fungal mycelia. By harnessing mycelia's innate electrical signals, the researchers discovered a new way of controlling 'biohybrid' robots that can potentially react to their environment better than their purely synthetic counterparts.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Target Review

SEPTEMBER 5, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I am a pharmacist by training and continued with a PhD in Clinical Pharmacology. However, my goal was all the time to work with drug development in the pharma industry, so I moved on and started that journey in 1992 when I took on a role as Clinical Research Manager at AstraHässle, a mid-size Swedish pharma company.

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Drug Discovery World

SEPTEMBER 6, 2024

Eli Lilly and biotechnology company HAYA Therapeutics have announced a multi-year agreement to apply HAYA’s RNA-guided regulatory genome platform to support preclinical drug discovery efforts in obesity and related metabolic conditions. The partners aim to identify multiple regulatory genome derived RNA-based drug targets to address these chronic conditions.

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Science Daily: Pharmacology News

SEPTEMBER 3, 2024

We all know the adage, 'You can't teach an old dog new tricks.' As we age, our ability to learn new skills, like mastering a foreign language or picking up a musical instrument, seems to fade. The culprit? A decline in brain plasticity - the brain's capacity to rewire itself and adapt to new challenges. But what if we could rewind the clock on this age-related decline?

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Research 129

Drugs.com

SEPTEMBER 3, 2024

TUESDAY, Sept. 3, 2024 -- The booming popularity of the weight-loss drug semaglutide has prompted increasing concerns about potential side effects from taking Ozempic or Wegovy.But a new study rules out one possible problem -- using semaglutide.

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Perficient: Drug Development

SEPTEMBER 4, 2024

Did you ever feel tense while taking your exams? Or you must have watched the Olympics or other sports events like cricket, football, etc. When you focus on national players during significant events, you can observe stress and anxiety in performing at that level. Similar is the situation of an IT professional during a production deployment call. This moment is crucial because it represents the end of months or years of effort, the results of which will be evaluated by those involved.

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Drug Discovery World

SEPTEMBER 5, 2024

Biotechnology company SeaBeLife has secured orphan drug designation (ODD) from the European Medicines Agency (EMA) for its drug candidate SBL01 in the treatment of acute liver failure (ALF). ALF occurs when the liver suddenly loses its ability to function in a person without a pre-existing liver disorder, and carries a high morbidity and mortality rate (85% when transplantation is not feasible).

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Clinical Trials

BioPharma Drive: Drug Pricing

SEPTEMBER 3, 2024

While results from two after-the-fact analyses were “reassuring,” outside experts urged “continued vigilance” to ensure GLP-1 drugs don’t worsen problems in people with preexisting mental health conditions.

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Science Daily: Pharmacology News

SEPTEMBER 4, 2024

Researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells. Mice given the treatment had improved recovery from injuries, demonstrating potential for developing the therapy for people.

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Drugs.com

SEPTEMBER 5, 2024

THURSDAY, Sept. 5, 2024 -- Ketamine is becoming a popular depression drug, but doctors aren’t keeping in mind the danger it can pose to a pregnancy, a new study warns.Ketamine can be very harmful to a developing fetus and should not be used during p.

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Drug Discovery Today

SEPTEMBER 6, 2024

Secure your ticket to visit the biggest lab industry trade show in the UK.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Discovery World

SEPTEMBER 5, 2024

A new on-demand webinar is now available to watch for free, entitled ‘ Customising biosafety cabinets: A holistic approach ‘ Watch this on-demand webinar from Nuaire to learn more about: Situations that may require a bespoke biosafety cabinet (BSC) instead of a standard one The process to collaborate with a manufacturer to build a BSC around your needs Planning for the unique certification and service requirements of a bespoke design Watch now.

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Drug Patent Watch

SEPTEMBER 4, 2024

Optimizing API manufacturing is crucial for ensuring the consistent production of high-quality APIs. The pharmaceutical industry has learned valuable lessons from various strategies and technologies that have significantly improved the efficiency, precision, and sustainability of API manufacturing processes. De-risking involves minimizing the uncertainty and unknowns in an API strategy.

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Science Daily: Pharmacology News

SEPTEMBER 2, 2024

Securing the world's water supply is one of the greatest challenges of our time. Researchers are now presenting an alternative method for quantifying the global risk of water scarcity. Results indicate higher risks to water supply than previously expected if accounting for the environmental conditions and governability where rain is produced.

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Government Research 129

Drugs.com

SEPTEMBER 3, 2024

TUESDAY, Sept. 3, 2024 -- New England is on alert following one death and a handful of infections of eastern equine encephalitis (EEE) virus.A New Hampshire resident died after contracting EEE, which is spread by mosquito bites, according to a.

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addgene Blog

SEPTEMBER 5, 2024

Imagine an antibody. Do you immediately visualize a Y-shaped protein reminiscent of the Addgene mascot Abi? If so, you are not alone. Full-sized antibodies dominate the world of research affinity reagents, and for good reason. However, sometimes you want a tool that is a little more compact — more of an antibody fragment rather than the whole thing.

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Research 78

Drug Discovery World

SEPTEMBER 6, 2024

News round-up for 2-6 September by DDW Senior Digital Content Editor Diana Spencer. With the release of clinical study results that led some media titles to ask if semaglutide could be a ‘fountain of youth’, this week our news highlights focus on clinical trials at a variety of different stages. The top stories: Colorectal cancer study to be discontinued NuCana has revealed that the NuTide:323 colorectal cancer study is being discontinued following a pre-planned initial analysis and recommendati

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NIOSH Science Blog: Drugs

SEPTEMBER 6, 2024

Happy Respiratory Protection Week 2024! Another year provides another opportunity to highlight resources to support informed workplace respiratory protection practices. NIOSH has been at the forefront of this effort for decades, testing and approving respirators used in U.S. occupational settings while also striving to provide the science necessary to inform complex respiratory protection decisions.

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Science Daily: Pharmacology News

SEPTEMBER 4, 2024

A new study shines a light on the enormous scale of uncollected rubbish and open burning of plastic waste in the first ever global plastics pollution inventory. Researchers used A.I. to model waste management in more than 50,000 municipalities around the world. This model allowed the team to predict how much waste was generated globally and what happens to it.

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Research 121

Drugs.com

SEPTEMBER 4, 2024

WEDNESDAY, Sept. 4, 2024 -- An experimental three-in-one blood pressure pill works better than layering on meds one at a time, a new clinical trial shows.After a month on the combo pill, 81% of patients had their blood pressure under control.

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FDA Law Blog: Biosimilars

SEPTEMBER 3, 2024

By Véronique Li, Senior Medical Device Regulation Expert & Jeffrey N. Gibbs — Thank you to readers of this blog. We received incredible feedback on our August 19 post analyzing the number of decision summaries that have been posted for De Novos. We are happy to report that fifteen new decision summaries have been posted as of August 28. Notably, two decision summaries were posted for De Novos that had been granted in 2020 and two were posted for De Novos granted this year.

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Drug Discovery World

SEPTEMBER 6, 2024

The Phase II NANOBRAINMETS trial of AGuIX has been validated by the Data Safety and Monitoring Board (DSMB) following a futility analysis scheduled after the enrolment and follow-up of 50% of patients in the study. The trial is being run by NH TherAguix, a biotechnology company developing novel nanomedicine solutions for precision radiotherapy in oncology, and is managed by the Dana Farber Cancer Institute.

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BioPharma Drive: Drug Pricing

SEPTEMBER 3, 2024

The company's value jumped by several billion dollars as trial results showed its experimental shot could match and, in some cases, even outperform Pfizer's market-leading Prevnar 20.

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Science Daily: Pharmacology News

SEPTEMBER 5, 2024

Forget about retinol night creams, researchers believe travel could be the best way to defy premature aging. An interdisciplinary study has applied the theory of entropy to tourism, finding that travel could have positive health benefits, including slowing down the signs of aging.

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Drugs.com

SEPTEMBER 4, 2024

TUESDAY, Sept. 4, 2024 -- An overgrowth of gut microorganisms that produce methane could be a cause of severe constipation in many people, a new review finds.These gut bugs belong to a class of microbe called archaea, and when they flourish too.

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Drug Patent Watch

SEPTEMBER 5, 2024

The pharmaceutical industry is a significant contributor to global carbon emissions, with a projected increase of over 300% by 2050 if left unchecked. This alarming trend has led to a growing need for sustainable practices in the industry, particularly in the development of generic drugs.

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Drug Discovery World

SEPTEMBER 3, 2024

Researchers from Flinders University and University of South Australia have unveiled a promising new strategy that could be used to treat the most aggressive forms of prostate cancer. This study, published in British Journal of Cancer , explores the role of a novel drug, CDKI-73, to tackle drug-resistant prostate cancer that defies conventional therapies.

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BioPharma Drive: Drug Pricing

SEPTEMBER 3, 2024

Tolebrutinib, which Sanofi acquired in a $3.7 billion deal, failed two studies in people with relapsing disease, but succeeded in a type of multiple sclerosis that has no approved therapies.

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Science Daily: Pharmacology News

SEPTEMBER 3, 2024

Around 4 billion years ago, an asteroid hit the Jupiter moon Ganymede. Now, a researcher realized that the Solar System's biggest moon's axis has shifted as a result of the impact, which confirmed that the asteroid was around 20 times larger than the one that ended the age of the dinosaurs on Earth, and caused one of the biggest impacts with clear traces in the Solar System.

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Drugs.com

SEPTEMBER 5, 2024

THURSDAY, Sept. 4, 2024 -- States with the most severe abortion restrictions are the least likely to offer support to struggling families, a new study has found.Anti-abortion states tend to have assistance programs that exclude many families on the.

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LifeSciVC

SEPTEMBER 4, 2024

By Ankit Mahadevia, chairman of Spero Therapeutics, as part of the From The Trenches feature of LifeSciVC A common theme in startup literature is that by cutting a range of unnecessary tasks, a step-change in results will follow. I’ve found most suggestions on achieving this state of prioritization nirvana unhelpful. Most of us know how to prioritize the obvious things, and after that, everything on one’s plate still feels justifiably important.

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