Drugs.com
DECEMBER 30, 2024
MONDAY, Dec. 30, 2024 -- Norovirus, a highly contagious stomach bug, is surging across the United States this winter, according to the latest data from the U.S. Centers for Disease Control and Prevention (CDC).The data shows 91 outbreaks of.
Science Daily: Pharmacology News
JANUARY 1, 2025
Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans -- including those causing flu, COVID, whooping cough and tuberculosis.
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Drugs.com
DECEMBER 26, 2024
THURSDAY, Dec. 26, 2024 -- Migraine patients often suffer a long time before docs zero in on the best dosage for drugs designed to prevent their terrible symptoms. But a recently approved daily migraine pill called Qulipta (atogepant) appears to be.
Chemical Biology and Drug Design
DECEMBER 29, 2024
Cover Image molekuul_be/Shutterstock.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Covalent Modifiers
DECEMBER 28, 2024
Ai-Lin Chen, Zih-Jheng Lin, Hsiao-Yu Chang, and Tsung-Shing Andrew Wang Journal of the American Chemical Society , 2025 [link] Reactive carbonyl species (RCS) are important biomarkers of oxidative stress-related diseases because of their highly reactive electrophilic nature. Despite their potential as triggers for prodrug activation, selective labeling approaches for RCS remain limited.
BioPharma Drive: Drug Pricing
JANUARY 2, 2025
Expected readouts in diabetes, cancer and depression headline a series of study results that could help the biotechnology sector regain its footing after a shaky year.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
DECEMBER 30, 2024
Compound 8w suppressed BaF3 cells harboring CCDC6-RET V804M mutations with IC 50 values of 0.715M and dose-dependently suppressed the activation of RET and downstream signals. Another compound 8s suppressed BaF3 cells harboring CCDC6-RET G810C mutation with an IC 50 value of 2.91M. Therefore, 8w and 8s might be promising lead compounds. ABSTRACT RET (Rearranged during transfection) kinase is a validated target for non-small cell lung cancer (NSCLC).
Drug Patent Watch
DECEMBER 30, 2024
The regulatory environment in Japan for generic drug development is complex and has undergone significant changes in recent years. This article aims to provide a comprehensive overview of the key aspects of the regulatory framework, highlighting the requirements and challenges faced by pharmaceutical companies seeking to introduce generic drugs into the Japanese market.
BioPharma Drive: Drug Pricing
JANUARY 2, 2025
The well-funded biotech lost most of its value after its drug flunked a late-stage trial. One analyst described the results as a “worst-case scenario for the program.
Drugs.com
DECEMBER 26, 2024
THURSDAY, Dec. 26, 2024 -- Female stroke victims are less likely than men to take drugs that could lower their odds of a second stroke.Women are 80% more likely to report that they dont take cholesterol-lowering medications as prescribed, a new s.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Science Daily: Pharmacology News
DECEMBER 27, 2024
The creation of more fox-free safe havens and greater collaboration between government and landowners is needed to ensure the survival of a species of wallaby, an expert argues. The Parma wallaby, also known as the white-throated wallaby, is listed as a vulnerable species in Australia, while the International Union for Conservation of Nature (IUCN) classifies it as Near Threatened.
Covalent Modifiers
JANUARY 1, 2025
Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R McKnight, Katelyn A Bustin, Eric W Barr, Snehil R Chilkamari, Mahaa Ayub, Sun Woo Kim, Zongtao Lin, Ren-Ming Hu, Kelly Hicks, Xie Wang, Donald M O'Rourke, J. Martin Bollinger Jr., Zev A Binder, William H Parsons, Kirill A Martemyanov, Aimin Liu, Megan L Matthews bioRxiv 2024.12.19.629450; doi: [link] The vasodilator hydralazine (HYZ) has been used clinically for ~ 70 years and remains on the World Health Organization's List of Essential Medicin
Collaborative Drug
DECEMBER 30, 2024
2024 was a special year as we celebrated two decades of CDD Vault.
BioPharma Drive: Drug Pricing
JANUARY 2, 2025
The agency’s main drug review office cleared 50 novel medicines last year, short of 2018’s record total but on the higher end of recent annual tallies.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
DECEMBER 27, 2024
FRIDAY, Dec. 27, 2024 -- The U.S. Food and Drug Administration (FDA) has proposed a new rule to require standardized testing of talc-containing cosmetics for asbestos, a known carcinogen linked to serious illnesses such as lung and ovarian.
Science Daily: Pharmacology News
JANUARY 1, 2025
Waves of human migration across Europe during the first millennium AD have been revealed using a more precise method of analysing ancestry with ancient DNA, in research led by the Francis Crick Institute.
Covalent Modifiers
DECEMBER 27, 2024
Guiqun Wang, Nico J. Seidler, Sandra Rhm, Yufeng Pan, Xiaojun Julia Liang, Lisa Haarer, Benedict-Tilman Berger, Saran Aswathaman Sivashanmugam, Valentin R. Wydra, Michael Forster, Stefan A. Laufer, Apirat Chaikuad, Matthias Gehringer, Stefan Knapp Angew. Chem. Int. Ed. 2024 , e202419736 [link] Protein kinases are important drug targets, yet specific inhibitors have been developed for only a fraction of the more than 500 human kinases.
addgene Blog
JANUARY 2, 2025
Every year, we like to add in some holiday cheer to our blog and social media. This year, we're doing so through the twelve days of antibodies. We hope you enjoy it, and we wish you a great 2025!
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
JANUARY 2, 2025
Sangamo shares fell on Pfizer’s decision to hand back rights to a hemophilia gene therapy. Elsewhere, Novartis got long-awaited data and BioNTech settled with the NIH.
Drugs.com
DECEMBER 26, 2024
THURSDAY, Dec. 26, 2024 -- The U.S. Food and Drug Administration (FDA) has escalated the recall of certain eggs sold at Costco to its highest Class 1 alert level due to salmonella contamination risks.According to the FDA, The Handsome Brook Farms.
Science Daily: Pharmacology News
JANUARY 1, 2025
Researchers report that they have invented new nanoscale sensors of force. They are luminescent nanocrystals that can change intensity and/or color when you push or pull on them. These 'all-optical' nanosensors are probed with light only and therefore allow for fully remote read-outs -- no wires or connections are needed.
Drug Patent Watch
DECEMBER 26, 2024
The biopharmaceutical sector has made significant strides in developing and delivering effective drugs to improve health and combat diseases. However, the high cost of prescription drugs remains a significant barrier to access for many patients. One key solution to this issue lies in the role of generic drugs, which are significantly cheaper than branded products and can help reduce the financial burden on patients and the healthcare system.
PPD
JANUARY 2, 2025
The biotech industry is a dynamic sector, rapidly evolving and poised for continued growth. Its ability to maneuver persistent drug development challenges, like patient recruitment, trial complexity and rising costs, will ultimately determine its success. Because biotech companies need to remain flexible and agile while remaining on time and on budget they are harnessing innovations to navigate unexpected drug development challenges and leveraging strategies to fill gaps in resources and exper
Perficient: Drug Development
DECEMBER 30, 2024
This blog provides a detailed explanation of the technical approach for implementing Continuous Deployment (CD) processes within Azure DevOps. It focuses on automating the deployment of solutions to SharePoint environments. This approach not only speeds up the release cycle but also enhances reliability, minimizes errors, and ensures that updates are deployed quickly and effectively.
Drugs.com
DECEMBER 27, 2024
FRIDAY, Dec. 27, 2024 A specific class of anti-inflammatory drugs can help children avoid a debilitating complication of Crohns disease.A new study published recently in the journal Gut shows children with Crohn's who were prescribed anti-TNF (.
Science Daily: Pharmacology News
JANUARY 1, 2025
Astronomers pinned down the origins of at least one fast radio burst, a brief and brilliant explosion of radio waves emitted by an extremely compact object. The team's novel technique might also reveal the sources of other FRBs.
Drug Patent Watch
DECEMBER 29, 2024
FENTORA (fentanyl citrate) Cephalon Patent: 8,119,158 Expiration: Dec 30, 2024 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.com or visit www.DrugPatentWatch.
Molecular Design
DECEMBER 31, 2024
My pulse will be quickenin' With each drop of strychnine We feed to a pigeon It just takes a smidgin To poison a pigeon in the park Tom Lehrer, Poisoning Pigeons in the Park | video ** Ill be reviewing the H2024 study (Occurrence of Natural Selection in Successful Small Molecule Drug Discovery) in this post. Derek has already posted on the H2024 study which been included in the BL2024 Virtual Special Issue on natural products (NPs) in medicinal chemistry.
Perficient: Drug Development
DECEMBER 27, 2024
Our new Agentforce Resource Center is here! This comprehensive resource is crafted to help businesses unlock tailored AI solutions, explore industry-specific use cases, and assess their Salesforce readiness. In the ever-evolving digital landscape, businesses need cutting-edge solutions to stay competitive and drive unparalleled results. Salesforce Agentforce 2.0 is here to revolutionize your operations with its suite of assistive and autonomous AI agents.
Drugs.com
DECEMBER 27, 2024
FRIDAY, Dec. 27, 2024 -- More Americans believe in the effectiveness of vaccines developed to protect newborns and seniors against respiratory syncytial virus (RSV).More than half of U.S. adults (52%) think the RSV vaccine given to pregnant women.
Science Daily: Pharmacology News
JANUARY 2, 2025
Viral infections may play a role in Alzheimer's disease.
Alta Sciences
DECEMBER 31, 2024
Inside The Altascientist: Understanding Drug Interaction Factors for Safer, More Effective Therapies pmjackson Tue, 12/31/2024 - 16:23 Intrinsic factors such as age, biological sex, comorbidities, or genetics can potentially alter drug exposure, as can extrinsic factors such as concomitant drugs, supplements, the environment, and food and beverages.
Chemical Biology and Drug Design
DECEMBER 26, 2024
New ()- cis - N -normetazocine derivatives were developed (compounds 3 8 ) and the most interesting compound 7 showed a significant MOR affinity and a similar docking mode with respect to previously synthesized compounds. Moreover, the limited BBB permeability of compound 7 suggests its potential for development as a peripherally restricted opioid ligand.
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