Science Daily: Pharmacology News
MARCH 31, 2025
A newly developed blood test for Alzheimer's disease not only aids in the diagnosis of the neurodegenerative condition but also indicates how far it has progressed, according to a new study.
BioPharma Drive: Drug Pricing
MARCH 31, 2025
Marks’ resignation leaves the field without a regulator many view as “integral” to its progress over the last decade.
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Covalent Modifiers
APRIL 2, 2025
Lszl Petri, Ronen Gabizon, Gyrgy G. Ferenczy, Nikolett Pczka, Attila Egyed, Pter brnyi-Balogh, Tams Takcs, and Gyrgy M. Keser Journal of Medicinal Chemistry 2025 68 (6), 6616-6632 DOI: 10.1021/acs.jmedchem.5c00017 Labeling proteins with covalent ligands is finding increasing use in proteomics applications, including identifying nucleophilic residues amenable for labeling and in the development of targeted covalent inhibitors (TCIs).
Drugs.com
APRIL 2, 2025
TUESDAY, April 2, 2025 -- The shingles vaccine can do more than protect seniors from painful, blistering rashes. It also appears to protect older folks from dementia, researchers say. Seniors who got the shingles vaccine when it became available.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Chemical Biology and Drug Design
APRIL 2, 2025
A multi-objective optimization algorithm incorporating the strategies of dynamic semi-parameter adaptation updating, gradient enhancement, and population size reduction is adopted to solve the problem of protein-ligand docking. ABSTRACT Molecular docking, which simulates the binding pose of a drug molecule to target proteins and predicts the binding affinity, is an important computational tool in structure-based drug discovery.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
MARCH 29, 2025
In his resignation letter, Marks cited disagreement with HHS Secretary Robert F. Kennedy Jr., who he said pushed “misinformation and lies.
FDA Law Blog: Biosimilars
APRIL 1, 2025
By Dr. Naomi Lowy, Principal Drug Regulatory Expert Trade and national press have reported that recent changes in FDA staffing levels have already led to slower responses to calls and emails. According to reports, which were published before the most recent reports of HHS staff level reductions and tumultuous changes in leadership, FDA staff were missing minor deadlines.
Drugs.com
MARCH 31, 2025
MONDAY, March 31, 2025 -- Use of cutting-edge weight-loss drugs like Ozempic and Zepbound has increased dramatically among people with type 1 diabetes, raising safety concerns among experts, a new study says.Both adults and children with type 1.
New Drug Approvals
APRIL 2, 2025
Suzetrigine CAS 2649467-58-1 Weight Average: 473.4 Monoisotopic: 473.137396951 Chemical Formula C 21 H 20 F 5 N 3 O 4 FDA 1/30/2025, Journavx To treat moderate to severe acute pain Press Release 2-Pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]- 4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5- dimethyl-5-(trifluoromethyl)oxolane-2- carboxamido]pyridine-2-carboxamide 4-[(2R,3S,4S,5R)-3-(3,4-difluor
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
APRIL 2, 2025
A 'weekend warrior' approach to physical activity -- getting 150 minutes of moderate-to-vigorous physical activity over one to two days instead of throughout the week -- improved health and lowered the risk of death, finds a new stud.
BioPharma Drive: Drug Pricing
APRIL 3, 2025
The Swiss drugmaker, which holds European rights to Elevidys, suspended three trials while researchers investigate the death of a young man who died following treatment.
Covalent Modifiers
APRIL 4, 2025
Amanda L. Waterbury, Jonatan Caroli, Olivia Zhang, Paloma R. Tuttle, Chao Liu, Jiaming Li, Ji Sung Park, Samuel M. Hoenig, Marco Barone, Airi Furui, Andrea Mattevi & Brian B. Liau Nat Commun 16 , 3156 (2025). [link] Chromatin modifiers often work in concert with transcription factors (TFs) and other complex members, where they can serve both enzymatic and scaffolding functions.
Drugs.com
MARCH 31, 2025
MONDAY, March 31, 2025 -- A top vaccine official at the U.S. Food and Drug Administration (FDA) is stepping down, warning that vaccine misinformation is coloring the countrys top health decisions.Dr. Peter Marks, director of the FDAs Center for Bi.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Chemical Biology and Drug Design
APRIL 2, 2025
ABSTRACT Diketopiperazines (DKPs) have emerged as promising candidates for treating diverse diseases, particularly cancer. In this context, 2,5-diketopiperazines have been extensively investigated in comparison with 2,6-diketopiperazines. This work explores the selectivity and impact of 2,6-diketopiperazine enantiomers derived from -amino acids on MDA-MB-231 triple-negative breast cancer cells (TNBC).
Science Daily: Pharmacology News
APRIL 2, 2025
Researchers have successfully developed a novel drug to restore vision. The treatment method restores vision through retinal nerve regeneration.
BioPharma Drive: Drug Pricing
MARCH 31, 2025
Shares in Moderna, Vaxcyte, Novavax and BioNTech all fell Monday after Peter Marks, head of the FDA office that reviews vaccines, resigned on Friday.
keypoint
APRIL 1, 2025
Keystone Symposia convened a panel of global health experts to discuss how, as a conference organization, we can extend the reach and impact of our conferences to improve human health worldwide.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
APRIL 3, 2025
THURSDAY, April 3, 2025 -- Health experts are warning that whooping cough, also known as pertussis, is making a dangerous comeback. Cases are rising across the country, and Louisiana recently reported that two infants have died -- the state’s.
Codon
MARCH 30, 2025
A cautionary tale about the competitive pressures of scientific research, and how they alter the course of history.
Science Daily: Pharmacology News
MARCH 31, 2025
New research reveals that lower proportions of specific sleep stages are associated with reduced brain volume in regions vulnerable to the development of Alzheimer's disease over time.
BioPharma Drive: Drug Pricing
MARCH 31, 2025
Accelerate biomarker research with high-quality, expert-curated data to drive precision medicine.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Fierce BioTech
MARCH 31, 2025
| Project Optimus is changing the landscape of oncology drug development by redefining dose optimization standards. Learn how sponsors can align with FDA expectations and implement more precise dose-finding strategies. Watch the full interview with Alex MacDonald now!
Drugs.com
MARCH 29, 2025
SATURDAY, March 29, 2025 -- A new formula made with natural citrus oil could help cancer patients find relief from dry mouth, a common and painful side effect of radiation treatments.The formula was created by researchers at the University of South.
thought leadership
APRIL 2, 2025
Navigating a Shifting Regulatory Landscape On Thursday, March 27, 2025, HHS announced that they would be conducting a reduction in force impacting nearly 3,500 full time FDA employees nearly 20% of the Agencys entire workforce. This comes on the tail end of a layoff in February of this year, when about 700 FDA employees were terminated.
Science Daily: Pharmacology News
APRIL 3, 2025
A switch of just two weeks from a traditional African diet to a Western diet causes inflammation, reduces the immune response to pathogens, and activates processes associated with lifestyle diseases. Conversely, an African diet rich in vegetables, fiber, and fermented foods has positive effects. This study highlights the significant impact of diet on the immune system and metabolism.
BioPharma Drive: Drug Pricing
APRIL 1, 2025
Reduction-in-force notices went out Tuesday morning to employees across HHS. At FDA, OND director Peter Stein is departing as cuts hit CDER.
DS in Pharmatics
APRIL 4, 2025
The Prescription Drug User Fee Act (PDUFA) has been a cornerstone of the U.S. Food and Drug Administrations (FDA) drug approval process since its inception in 1992.
Drugs.com
APRIL 1, 2025
TUESDAY, April 1, 2025 -- Hundreds of U.S. research projects aimed at boosting vaccine confidence have been shut down -- just as preventable diseases like measles and flu are on the rise. Since Jan. 20, the U.S. Department of Health and Human.
thought leadership
APRIL 4, 2025
The US Government recently modified their policy to utilize tariffs to in an effort to support the US economy. Pharmaceutical tariffs have been announced causing many global organizations to investigate the consequences of the tariffs on their overall product portfolio. Companies need to know the facts and have data to support their decisions.
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