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Transforming high-throughput screening with mass spectrometry

Drug Discovery World

Figure 3: Quantitative analysis of a drug-like molecule (MW 543 Da), showing the elimination of interfering assay background and the consequent improvement in quantitation using TIMS in conjunction with MALDI-MS/MS. Büttner and colleagues, Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.